| The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase TF Franke, SI Yang, TO Chan, K Datta, A Kazlauskas, DK Morrison, ... Cell 81 (5), 727-736, 1995 | 2618 | 1995 |
| Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission HA Hirsch, D Iliopoulos, PN Tsichlis, K Struhl Cancer research 69 (19), 7507-7511, 2009 | 1363 | 2009 |
| A Retroviral Oncogene, akt, Encoding a Serine-Threonine Kinase Containing an SH2-Like Region A Bellacosa, JR Testa, SP Staal, PN Tsichlis Science 254 (5029), 274-277, 1991 | 1362 | 1991 |
| The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. SG Kennedy, AJ Wagner, SD Conzen, J Jordan, A Bellacosa, PN Tsichlis, ... Genes & development 11 (6), 701-713, 1997 | 1357 | 1997 |
| AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation TO Chan, SE Rittenhouse, PN Tsichlis Annual review of biochemistry 68 (1), 965-1014, 1999 | 1292 | 1999 |
| TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway CD Dumitru, JD Ceci, C Tsatsanis, D Kontoyiannis, K Stamatakis, JH Lin, ... Cell 103 (7), 1071-1083, 2000 | 1035 | 2000 |
| AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. JQ Cheng, AK Godwin, A Bellacosa, T Taguchi, TF Franke, TC Hamilton, ... Proceedings of the National Academy of Sciences 89 (19), 9267-9271, 1992 | 997 | 1992 |
| Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer G Viglietto, ML Motti, P Bruni, RM Melillo, A D'alessio, D Califano, F Vinci, ... Nature medicine 8 (10), 1136-1144, 2002 | 890 | 2002 |
| The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines SJ Grille, A Bellacosa, J Upson, AJ Klein-Szanto, F Van Roy, W Lee-Kwon, ... Cancer research 63 (9), 2172-2178, 2003 | 846 | 2003 |
| Transformation of hematopoietic cells by BCR/ABL requires activation of a PI‐3k/Akt‐dependent pathway T Skorski, A Bellacosa, M Nieborowska‐Skorska, M Majewski, R Martinez, ... The EMBO journal, 1997 | 818 | 1997 |
| Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function AD Basso, DB Solit, G Chiosis, B Giri, P Tsichlis, N Rosen Journal of Biological Chemistry 277 (42), 39858-39866, 2002 | 781 | 2002 |
| Akt activation by growth factors is a multiple-step process: the role of the PH domain A Bellacosa, TO Chan, NN Ahmed, K Datta, S Malstrom, D Stokoe, ... Oncogene 17 (3), 313-325, 1998 | 743 | 1998 |
| Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway RC Muise-Helmericks, HL Grimes, A Bellacosa, SE Malstrom, PN Tsichlis, ... Journal of Biological Chemistry 273 (45), 29864-29872, 1998 | 682 | 1998 |
| The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs A Androulidaki, D Iliopoulos, A Arranz, C Doxaki, S Schworer, ... Immunity 31 (2), 220-231, 2009 | 679 | 2009 |
| Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase NN Ahmed, HL Grimes, A Bellacosa, TO Chan, PN Tsichlis Proceedings of the National Academy of Sciences 94 (8), 3627-3632, 1997 | 665 | 1997 |
| AKT1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells M Sun, G Wang, JE Paciga, RI Feldman, ZQ Yuan, XL Ma, SA Shelley, ... The American journal of pathology 159 (2), 431-437, 2001 | 644 | 2001 |
| Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation WG King, MD Mattaliano, TO Chan, PN Tsichlis, JS Brugge Molecular and cellular biology, 1997 | 567 | 1997 |
| Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization A Arranz, C Doxaki, E Vergadi, Y Martinez de la Torre, K Vaporidi, ... Proceedings of the National Academy of Sciences 109 (24), 9517-9522, 2012 | 562 | 2012 |
| Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase HW Chang, M Aoki, D Fruman, KR Auger, A Bellacosa, PN Tsichlis, ... Science 276 (5320), 1848-1850, 1997 | 533 | 1997 |
| Tcl1 enhances Akt kinase activity and mediates its nuclear translocation Y Pekarsky, A Koval, C Hallas, R Bichi, M Tresini, S Malstrom, G Russo, ... Proceedings of the National Academy of Sciences 97 (7), 3028-3033, 2000 | 491 | 2000 |
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