Structure‐based design of inhibitors of protein–protein interactions: mimicking peptide binding epitopes M Pelay‐Gimeno, A Glas, O Koch, TN Grossmann Angewandte Chemie International Edition 54 (31), 8896-8927, 2015 | 712 | 2015 |
Modulators of protein–protein interactions LG Milroy, TN Grossmann, S Hennig, L Brunsveld, C Ottmann Chemical reviews 114 (9), 4695-4748, 2014 | 497 | 2014 |
Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis YW Kim, TN Grossmann, GL Verdine Nature protocols 6 (6), 761-771, 2011 | 443 | 2011 |
New modalities for challenging targets in drug discovery E Valeur, SM Guéret, H Adihou, R Gopalakrishnan, M Lemurell, ... Angewandte Chemie International Edition 56 (35), 10294-10323, 2017 | 358 | 2017 |
Hydrocarbon stapled peptides as modulators of biological function PM Cromm, J Spiegel, TN Grossmann ACS chemical biology 10 (6), 1362-1375, 2015 | 294 | 2015 |
Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin TN Grossmann, JTH Yeh, BR Bowman, Q Chu, RE Moellering, ... Proceedings of the National Academy of Sciences 109 (44), 17942-17947, 2012 | 287 | 2012 |
Small-molecule modulation of Ras signaling J Spiegel, PM Cromm, G Zimmermann, TN Grossmann, H Waldmann Nature chemical biology 10 (8), 613-622, 2014 | 269 | 2014 |
Towards understanding cell penetration by stapled peptides Q Chu, RE Moellering, GJ Hilinski, YW Kim, TN Grossmann, JTH Yeh, ... MedChemComm 6 (1), 111-119, 2015 | 261 | 2015 |
Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets MD White, M Klecker, RJ Hopkinson, DA Weits, C Mueller, C Naumann, ... Nature communications 8 (1), 14690, 2017 | 190 | 2017 |
DNA-catalyzed transfer of a reporter group TN Grossmann, O Seitz Journal of the American Chemical Society 128 (49), 15596-15597, 2006 | 160 | 2006 |
Constrained peptides with target‐adapted cross‐links as inhibitors of a pathogenic protein–protein interaction A Glas, D Bier, G Hahne, C Rademacher, C Ottmann, TN Grossmann Angewandte Chemie International Edition 53 (9), 2489-2493, 2014 | 156 | 2014 |
Triplex molecular beacons as modular probes for DNA detection TN Grossmann, L Röglin, O Seitz Angewandte Chemie International Edition 46 (27), 5223-5225, 2007 | 144 | 2007 |
Bifunctional stapled polypeptides and uses thereof GL Verdine, TN Grossmann, RE Moellering, THJ Yeh, YRY Liang, Y Oak US Patent 9,163,330, 2015 | 135 | 2015 |
Achieving turnover in DNA‐templated reactions TN Grossmann, A Strohbach, O Seitz ChemBioChem 9 (14), 2185-2192, 2008 | 132 | 2008 |
Cell permeable stapled peptide inhibitor of Wnt signaling that targets β-catenin protein-protein interactions L Dietrich, B Rathmer, K Ewan, T Bange, S Heinrichs, TC Dale, D Schade, ... Cell chemical biology 24 (8), 958-968. e5, 2017 | 120 | 2017 |
Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns WS Horne, TN Grossmann Nature chemistry 12 (4), 331-337, 2020 | 114 | 2020 |
Direct Targeting of Rab‐GTPase–Effector Interactions J Spiegel, PM Cromm, A Itzen, RS Goody, TN Grossmann, H Waldmann Angewandte Chemie International Edition 53 (9), 2498-2503, 2014 | 104 | 2014 |
Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides PM Cromm, S Schaubach, J Spiegel, A Fürstner, TN Grossmann, ... Nature communications 7 (1), 11300, 2016 | 103 | 2016 |
Nucleic acid templated reactions: consequences of probe reactivity and readout strategy for amplified signaling and sequence selectivity TN Grossmann, O Seitz Chemistry–A European Journal 15 (27), 6723-6730, 2009 | 88 | 2009 |
Reversible covalent inhibition of a protein target CU Lee, TN Grossmann Angewandte Chemie International Edition 35 (51), 8699-8700, 2012 | 85 | 2012 |