| Kinase activity is required for the toxic effects of mutant LRRK2/dardarin E Greggio, S Jain, A Kingsbury, R Bandopadhyay, P Lewis, A Kaganovich, ... Neurobiology of disease 23 (2), 329-341, 2006 | 854 | 2006 |
| Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease A Beilina, IN Rudenko, A Kaganovich, L Civiero, H Chau, SK Kalia, ... Proceedings of the National Academy of Sciences 111 (7), 2626-2631, 2014 | 386 | 2014 |
| The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation E Greggio, I Zambrano, A Kaganovich, A Beilina, JM Taymans, V Daniëls, ... Journal of Biological Chemistry 283 (24), 16906-16914, 2008 | 379 | 2008 |
| The R1441C mutation of LRRK2 disrupts GTP hydrolysis PA Lewis, E Greggio, A Beilina, S Jain, A Baker, MR Cookson Biochemical and biophysical research communications 357 (3), 668-671, 2007 | 352 | 2007 |
| Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions E Greggio, MR Cookson ASN neuro 1 (1), AN20090007, 2009 | 339 | 2009 |
| Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1 J Blackinton, M Lakshminarasimhan, KJ Thomas, R Ahmad, E Greggio, ... Journal of Biological Chemistry 284 (10), 6476-6485, 2009 | 308 | 2009 |
| Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase J Deng, PA Lewis, E Greggio, E Sluch, A Beilina, MR Cookson Proceedings of the National Academy of Sciences 105 (5), 1499-1504, 2008 | 289 | 2008 |
| The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2 L Wang, C Xie, E Greggio, L Parisiadou, H Shim, L Sun, J Chandran, ... Journal of Neuroscience 28 (13), 3384-3391, 2008 | 229 | 2008 |
| LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease? I Russo, L Bubacco, E Greggio Journal of neuroinflammation 11, 1-9, 2014 | 197 | 2014 |
| The Parkinson’s disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites E Greggio, JM Taymans, EY Zhen, J Ryder, R Vancraenenbroeck, ... Biochemical and biophysical research communications 389 (3), 449-454, 2009 | 193 | 2009 |
| GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2 A Biosa, A Trancikova, L Civiero, L Glauser, L Bubacco, E Greggio, ... Human molecular genetics 22 (6), 1140-1156, 2013 | 172 | 2013 |
| Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant V Daniëls, R Vancraenenbroeck, BMH Law, E Greggio, E Lobbestael, ... Journal of neurochemistry 116 (2), 304-315, 2011 | 162 | 2011 |
| Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease E Greggio, E Bergantino, D Carter, R Ahmad, GE Costin, VJ Hearing, ... Journal of neurochemistry 93 (1), 246-256, 2005 | 142 | 2005 |
| DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function N Plotegher, G Berti, E Ferrari, I Tessari, M Zanetti, L Lunelli, E Greggio, ... Scientific reports 7 (1), 40699, 2017 | 139 | 2017 |
| Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells I Russo, G Berti, N Plotegher, G Bernardo, R Filograna, L Bubacco, ... Journal of neuroinflammation 12, 1-13, 2015 | 138 | 2015 |
| Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers L Civiero, R Vancraenenbroeck, E Belluzzi, A Beilina, E Lobbestael, ... Public Library of Science 7 (8), e43472, 2012 | 122 | 2012 |
| Exosomes-associated neurodegeneration and progression of Parkinson’s disease I Russo, L Bubacco, E Greggio American journal of neurodegenerative disease 1 (3), 217, 2012 | 122 | 2012 |
| MKK6 binds and regulates expression of Parkinson’s disease‐related protein LRRK2 CH Hsu, D Chan, E Greggio, S Saha, MD Guillily, A Ferree, K Raghavan, ... Journal of neurochemistry 112 (6), 1593-1604, 2010 | 116 | 2010 |
| Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid G De Franceschi, E Frare, M Pivato, A Relini, A Penco, E Greggio, ... Journal of Biological Chemistry 286 (25), 22262-22274, 2011 | 112 | 2011 |
| The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation A Kumar, E Greggio, A Beilina, A Kaganovich, D Chan, JM Taymans, ... PloS one 5 (1), e8730, 2010 | 111 | 2010 |
