| Quinoline anti-malarial drugs inhibit spontaneous formation of β-haematin (malaria pigment) TJ Egan, DC Ross, PA Adams FEBS letters 352 (1), 54-57, 1994 | 506 | 1994 |
| Structure− function relationships in aminoquinolines: effect of amino and chloro groups on quinoline− hematin complex formation, inhibition of β-hematin formation, and … TJ Egan, R Hunter, CH Kaschula, HM Marques, A Misplon, J Walden Journal of medicinal chemistry 43 (2), 283-291, 2000 | 427 | 2000 |
| Fate of haem iron in the malaria parasite Plasmodium falciparum. TJ Egan, JM Combrinck, J Egan, GR Hearne, HM Marques, S Ntenteni, ... Biochemical Journal 365 (Pt 2), 343, 2002 | 392 | 2002 |
| Haemozoin formation TJ Egan Molecular and biochemical parasitology 157 (2), 127-136, 2008 | 311 | 2008 |
| Structure− activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position CH Kaschula, TJ Egan, R Hunter, N Basilico, S Parapini, D Taramelli, ... Journal of Medicinal Chemistry 45 (16), 3531-3539, 2002 | 311 | 2002 |
| Insights into the role of heme in the mechanism of action of antimalarials JM Combrinck, TE Mabotha, KK Ncokazi, MA Ambele, D Taylor, PJ Smith, ... ACS chemical biology 8 (1), 133-137, 2013 | 286 | 2013 |
| A colorimetric high-throughput β-hematin inhibition screening assay for use in the search for antimalarial compounds KK Ncokazi, TJ Egan Analytical biochemistry 338 (2), 306-319, 2005 | 282 | 2005 |
| Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation TJ Egan Journal of inorganic biochemistry 102 (5-6), 1288-1299, 2008 | 259 | 2008 |
| Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds EM Guantai, K Ncokazi, TJ Egan, J Gut, PJ Rosenthal, PJ Smith, ... Bioorganic & medicinal chemistry 18 (23), 8243-8256, 2010 | 245 | 2010 |
| The mechanism of β-hematin formation in acetate solution. Parallels between hemozoin formation and biomineralization processes TJ Egan, WW Mavuso, KK Ncokazi Biochemistry 40 (1), 204-213, 2001 | 219 | 2001 |
| Thermodynamic factors controlling the interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX TJ Egan, WW Mavuso, DC Ross, HM Marques Journal of Inorganic Biochemistry 68 (2), 137-145, 1997 | 219 | 1997 |
| Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity C Biot, D Taramelli, I Forfar-Bares, LA Maciejewski, M Boyce, ... Molecular pharmaceutics 2 (3), 185-193, 2005 | 208 | 2005 |
| The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance F Dubar, TJ Egan, B Pradines, D Kuter, KK Ncokazi, D Forge, JF Paul, ... ACS chemical biology 6 (3), 275-287, 2011 | 203 | 2011 |
| Speciation and structure of ferriprotoporphyrin IX in aqueous solution: spectroscopic and diffusion measurements demonstrate dimerization, but not μ-oxo dimer formation KA de Villiers, CH Kaschula, TJ Egan, HM Marques JBIC Journal of Biological Inorganic Chemistry 12, 101-117, 2007 | 182 | 2007 |
| Haemozoin (β-haematin) biomineralization occurs by self-assembly near the lipid/water interface TJ Egan, JYJ Chen, KA de Villiers, TE Mabotha, KJ Naidoo, KK Ncokazi, ... FEBS letters 580 (21), 5105-5110, 2006 | 175 | 2006 |
| Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator T Hänscheid, TJ Egan, MP Grobusch The Lancet infectious diseases 7 (10), 675-685, 2007 | 156 | 2007 |
| Standardization of the physicochemical parameters to assess in vitro the β-hematin inhibitory activity of antimalarial drugs S Parapini, N Basilico, E Pasini, TJ Egan, P Olliaro, D Taramelli, D Monti Experimental parasitology 96 (4), 249-256, 2000 | 154 | 2000 |
| The crystal structure of halofantrine–ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials KA de Villiers, HM Marques, TJ Egan Journal of inorganic biochemistry 102 (8), 1660-1667, 2008 | 149 | 2008 |
| Quinoline antimalarials decrease the rate of β-hematin formation TJ Egan, KK Ncokazi Journal of Inorganic Biochemistry 99 (7), 1532-1539, 2005 | 148 | 2005 |
| Interactions of quinoline antimalarials with hematin in solution TJ Egan Journal of inorganic biochemistry 100 (5-6), 916-926, 2006 | 142 | 2006 |
