| Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution BC Chen, WR Legant, K Wang, L Shao, DE Milkie, MW Davidson, ... Science 346 (6208), 1257998, 2014 | 1989 | 2014 |
| Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels S Khetan, M Guvendiren, WR Legant, DM Cohen, CS Chen, JA Burdick Nature materials 12 (5), 458-465, 2013 | 1243 | 2013 |
| Applying systems-level spectral imaging and analysis to reveal the organelle interactome AM Valm, S Cohen, WR Legant, J Melunis, U Hershberg, E Wait, ... Nature 546 (7656), 162-167, 2017 | 949 | 2017 |
| Measurement of mechanical tractions exerted by cells in three-dimensional matrices WR Legant, JS Miller, BL Blakely, DM Cohen, GM Genin, CS Chen Nature methods 7 (12), 969-971, 2010 | 737 | 2010 |
| Single-molecule dynamics of enhanceosome assembly in embryonic stem cells J Chen, Z Zhang, L Li, BC Chen, A Revyakin, B Hajj, W Legant, M Dahan, ... Cell 156 (6), 1274-1285, 2014 | 597 | 2014 |
| Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues WR Legant, A Pathak, MT Yang, VS Deshpande, RM McMeeking, ... Proceedings of the National Academy of Sciences 106 (25), 10097-10102, 2009 | 523 | 2009 |
| A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues T Boudou, WR Legant, A Mu, MA Borochin, N Thavandiran, M Radisic, ... Tissue Engineering Part A 18 (9-10), 910-919, 2012 | 492 | 2012 |
| Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER J Nixon-Abell, CJ Obara, AV Weigel, D Li, WR Legant, CS Xu, HA Pasolli, ... Science 354 (6311), aaf3928, 2016 | 431 | 2016 |
| Actin depletion initiates events leading to granule secretion at the immunological synapse AT Ritter, Y Asano, JC Stinchcombe, NMG Dieckmann, BC Chen, ... Immunity 42 (5), 864-876, 2015 | 329 | 2015 |
| Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions WR Legant, CK Choi, JS Miller, L Shao, L Gao, E Betzig, CS Chen Proceedings of the National Academy of Sciences 110 (3), 881-886, 2013 | 328 | 2013 |
| High-density three-dimensional localization microscopy across large volumes WR Legant, L Shao, JB Grimm, TA Brown, DE Milkie, BB Avants, LD Lavis, ... Nature methods 13 (4), 359-365, 2016 | 306 | 2016 |
| Bioactive hydrogels made from step-growth derived PEG–peptide macromers JS Miller, CJ Shen, WR Legant, JD Baranski, BL Blakely, CS Chen Biomaterials 31 (13), 3736-3743, 2010 | 273 | 2010 |
| Phase separation drives aberrant chromatin looping and cancer development JH Ahn, ES Davis, TA Daugird, S Zhao, IY Quiroga, H Uryu, J Li, AJ Storey, ... Nature 595 (7868), 591-595, 2021 | 245 | 2021 |
| 3D imaging of Sox2 enhancer clusters in embryonic stem cells Z Liu, WR Legant, BC Chen, L Li, JB Grimm, LD Lavis, E Betzig, R Tjian elife 3, e04236, 2014 | 238 | 2014 |
| Carbofluoresceins and carborhodamines as scaffolds for high-contrast fluorogenic probes JB Grimm, AJ Sung, WR Legant, P Hulamm, SM Matlosz, E Betzig, ... ACS chemical biology 8 (6), 1303-1310, 2013 | 222 | 2013 |
| Deep learning enables fast and dense single-molecule localization with high accuracy A Speiser, LR Müller, P Hoess, U Matti, CJ Obara, WR Legant, A Kreshuk, ... Nature methods 18 (9), 1082-1090, 2021 | 150 | 2021 |
| Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy F Aguet, S Upadhyayula, R Gaudin, Y Chou, E Cocucci, K He, BC Chen, ... Molecular biology of the cell 27 (22), 3418-3435, 2016 | 130 | 2016 |
| Real-time imaging of Huntingtin aggregates diverting target search and gene transcription L Li, H Liu, P Dong, D Li, WR Legant, JB Grimm, LD Lavis, E Betzig, ... Elife 5, e17056, 2016 | 100 | 2016 |
| Force-induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis WR Legant, CS Chen, V Vogel Integrative Biology 4 (10), 1164-1174, 2012 | 93 | 2012 |
| Diffusion of MMPs on the surface of collagen fibrils: the mobile cell surface–collagen substratum interface IE Collier, W Legant, B Marmer, O Lubman, S Saffarian, T Wakatsuki, ... PloS one 6 (9), e24029, 2011 | 85 | 2011 |
