A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal … VM Baragi, G Becher, AM Bendele, R Biesinger, H Bluhm, J Boer, H Deng, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2009 | 225 | 2009 |
Fragment-based approaches in drug discovery DA Erlanson, W Jahnke Wiley-VCH, 2006 | 198 | 2006 |
Target-induced formation of neuraminidase inhibitors from in vitro virtual combinatorial libraries M Hochgürtel, H Kroth, D Piecha, MW Hofmann, C Nicolau, S Krause, ... Proceedings of the National Academy of Sciences 99 (6), 3382-3387, 2002 | 185 | 2002 |
Structure–activity relationship of inhibition of fish feeding by sponge-derived and synthetic pyrrole–imidazole alkaloids T Lindel, H Hoffmann, M Hochgürtel, JR Pawlik Journal of Chemical Ecology 26, 1477-1496, 2000 | 128 | 2000 |
Ketones as building blocks for dynamic combinatorial libraries: highly active neuraminidase inhibitors generated via selection pressure of the biological target M Hochgürtel, R Biesinger, H Kroth, D Piecha, MW Hofmann, S Krause, ... Journal of medicinal chemistry 46 (3), 356-358, 2003 | 125 | 2003 |
Synthesis of the Marine Natural Product Oroidin and Its Z-Isomer T Lindel, M Hochgürtel The Journal of Organic Chemistry 65 (9), 2806-2809, 2000 | 86 | 2000 |
Fragment-based approaches in drug discovery VM Krishnamurthy, LA Estroff, GM Whitesides Multivalency in Ligand Design, Wiley-VCH, 2006 | 71* | 2006 |
Synthesis of the Marine Natural Product Nα-(4-Bromopyrrolyl-2-carbonyl)-l-homoarginine, a Putative Biogenetic Precursor of the Pyrrole−Imidazole Alkaloids T Lindel, M Hochgürtel, M Assmann, M Köck Journal of natural products 63 (11), 1566-1569, 2000 | 62 | 2000 |
Decomposition of oroidin in DMSO/TFA T Lindel, G Breckle, M Hochgürtel, C Volk, A Grube, M Köck Tetrahedron letters 45 (44), 8149-8152, 2004 | 42 | 2004 |
The alkyne pathway to keramadine from the marine sponge Agelas sp. T Lindel, M Hochgürtel Tetrahedron letters 39 (17), 2541-2544, 1998 | 35 | 1998 |
Heterobicyclic metalloprotease inhibitors C Steeneck, C Gege, F Richter, H Kroth, M Hochguertel, M Essers, ... US Patent App. 11/602,140, 2007 | 33 | 2007 |
Multicyclic bis-amide MMP inhibitors T Powers, C Steeneck, R Biesinger, H Bluhm, H Deng, R Dodd, ... US Patent App. 11/324,037, 2006 | 30 | 2006 |
Metalloprotease inhibitors containing a heterocyclic moiety C Gege, H Bluhm, M Hochgurtel, M Schneider, C Chevrier, A Taveras US Patent App. 12/074,917, 2008 | 27 | 2008 |
Total Synthesis of (+)‐Erogorgiaene and the Pseudopterosin A− F Aglycone via Enantioselective Cobalt‐Catalyzed Hydrovinylation S Movahhed, J Westphal, A Kempa, CE Schumacher, J Sperlich, ... Chemistry–A European Journal 27 (45), 11574-11579, 2021 | 12 | 2021 |
Heterobicyclic metalloprotease inhibitors B Gallagher, J Van Veldhuizen, X Wu, H Deng, I Sucholeiki, ... US Patent App. 11/602,116, 2007 | 11 | 2007 |
Glycosylation of caffeic acid and structural analogues catalyzed by novel glucansucrases from Leuconostoc and Weissella species J Nolte, A Kempa, A Schlockermann, M Hochgürtel, U Schörken Biocatalysis and Agricultural Biotechnology 19, 101114, 2019 | 10 | 2019 |
Fragment-based approaches in drug discovery M Hochgürtel, JM Lehn Wiley-VCH, Weinheim.(c) Ramström O, Lehn JM (2007) Comprehensive medicinal …, 2006 | 9 | 2006 |
Dipeptidyl peptidase-iv inhibitors H Kroth, T Feuerstein, F Richter, J Boer, M Essers, B Nolte, M Schneider, ... US Patent App. 12/492,254, 2010 | 6 | 2010 |
Dynamic combinatorial diversity in drug discovery M Hochgürtel, JM Lehn Fragment-based Approaches in Drug Discovery 34, 341-364, 2006 | 6 | 2006 |
Heterobicyclic metalloprotease inhibitors H Bluhm, M Hochgurtel, H Kroth, M Essers, C Gege, F Richter, A Taveras US Patent App. 11/986,586, 2008 | 5 | 2008 |