Targeting cancer with small molecule kinase inhibitors J Zhang, PL Yang, NS Gray Nature reviews cancer 9 (1), 28-39, 2009 | 3311 | 2009 |
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 CC Thoreen, SA Kang, JW Chang, Q Liu, J Zhang, Y Gao, LJ Reichling, ... Journal of Biological Chemistry 284 (12), 8023-8032, 2009 | 2042 | 2009 |
Activating mutations in ALK provide a therapeutic target in neuroblastoma RE George, T Sanda, M Hanna, S Fröhling, WL Ii, J Zhang, Y Ahn, ... Nature 455 (7215), 975-978, 2008 | 1018 | 2008 |
Systematic identification of culture conditions for induction and maintenance of naive human pluripotency TW Theunissen, BE Powell, H Wang, M Mitalipova, DA Faddah, J Reddy, ... Cell stem cell 15 (4), 471-487, 2014 | 962 | 2014 |
MEK1 mutations confer resistance to MEK and B-RAF inhibition CM Emery, KG Vijayendran, MC Zipser, AM Sawyer, L Niu, JJ Kim, ... Proceedings of the National Academy of Sciences 106 (48), 20411-20416, 2009 | 770 | 2009 |
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors J Zhang, FJ Adrián, W Jahnke, SW Cowan-Jacob, AG Li, RE Iacob, T Sim, ... Nature 463 (7280), 501-506, 2010 | 691 | 2010 |
Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer PS Hammerman, ML Sos, AH Ramos, C Xu, A Dutt, W Zhou, LE Brace, ... Cancer discovery 1 (1), 78-89, 2011 | 583 | 2011 |
Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor CL Christensen, N Kwiatkowski, BJ Abraham, J Carretero, F Al-Shahrour, ... Cancer cell 26 (6), 909-922, 2014 | 453 | 2014 |
Discovery of potent and selective covalent inhibitors of JNK T Zhang, F Inesta-Vaquera, M Niepel, J Zhang, SB Ficarro, T Machleidt, ... Chemistry & biology 19 (1), 140-154, 2012 | 361 | 2012 |
In situ kinase profiling reveals functionally relevant properties of native kinases MP Patricelli, TK Nomanbhoy, J Wu, H Brown, D Zhou, J Zhang, ... Chemistry & biology 18 (6), 699-710, 2011 | 348 | 2011 |
Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective … Q Liu, JW Chang, J Wang, SA Kang, CC Thoreen, A Markhard, W Hur, ... Journal of medicinal chemistry 53 (19), 7146-7155, 2010 | 281 | 2010 |
A structure-guided approach to creating covalent FGFR inhibitors W Zhou, W Hur, U McDermott, A Dutt, W Xian, SB Ficarro, J Zhang, ... Chemistry & biology 17 (3), 285-295, 2010 | 215 | 2010 |
Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer Y Liu, K Marks, GS Cowley, J Carretero, Q Liu, TJF Nieland, C Xu, ... Cancer discovery 3 (8), 870-879, 2013 | 143 | 2013 |
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells M Taipale, I Krykbaeva, L Whitesell, S Santagata, J Zhang, Q Liu, NS Gray, ... Nature biotechnology 31 (7), 630-637, 2013 | 140 | 2013 |
EPHA2 is a mediator of vemurafenib resistance and a novel therapeutic target in melanoma B Miao, Z Ji, L Tan, M Taylor, J Zhang, HG Choi, DT Frederick, R Kumar, ... Cancer discovery 5 (3), 274-287, 2015 | 138 | 2015 |
A complex network of factors with overlapping affinities represses splicing through intronic elements Y Wang, X Xiao, J Zhang, R Choudhury, A Robertson, K Li, M Ma, ... Nature structural & molecular biology 20 (1), 36-45, 2013 | 130 | 2013 |
Evolving protein functional diversity in new genes of Drosophila J Zhang, AM Dean, F Brunet, M Long Proceedings of the National Academy of Sciences 101 (46), 16246-16250, 2004 | 121 | 2004 |
Direct targeting of β-catenin by a small molecule stimulates proteasomal degradation and suppresses oncogenic Wnt/β-catenin signaling SY Hwang, X Deng, S Byun, C Lee, SJ Lee, H Suh, J Zhang, Q Kang, ... Cell reports 16 (1), 28-36, 2016 | 119 | 2016 |
The Origin of the Jingwei Gene and the Complex Modular Structure of Its Parental Gene, Yellow Emperor, in Drosophila melanogaster W Wang, J Zhang, C Alvarez, A Llopart, M Long Molecular Biology and Evolution 17 (9), 1294-1301, 2000 | 118 | 2000 |
Targeting Cdk11 in osteosarcoma cells using the CRISPR‐cas9 system Y Feng, S Sassi, JK Shen, X Yang, Y Gao, E Osaka, J Zhang, S Yang, ... Journal of orthopaedic research 33 (2), 199-207, 2015 | 93 | 2015 |