Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1 EG Geier, A Schlessinger, H Fan, JE Gable, JJ Irwin, A Sali, KM Giacomini Proceedings of the National Academy of Sciences 110 (14), 5480-5485, 2013 | 202 | 2013 |
Hydrogen bonding and solvent polarity markers in the UV resonance Raman spectrum of tryptophan: application to membrane proteins DE Schlamadinger, JE Gable, JE Kim The Journal of Physical Chemistry B 113 (44), 14769-14778, 2009 | 81 | 2009 |
Effects of tryptophan microenvironment, soluble domain, and vesicle size on the thermodynamics of membrane protein folding: lessons from the transmembrane protein OmpA KM Sanchez, JE Gable, DE Schlamadinger, JE Kim Biochemistry 47 (48), 12844-12852, 2008 | 50 | 2008 |
Enzyme inhibition by allosteric capture of an inactive conformation GM Lee, T Shahian, A Baharuddin, JE Gable, CS Craik Journal of molecular biology 411 (5), 999-1016, 2011 | 41 | 2011 |
Förster resonance energy transfer and conformational stability of proteins. An advanced biophysical module for physical chemistry students KM Sanchez, DE Schlamadinger, JE Gable, JE Kim Journal of chemical education 85 (9), 1253, 2008 | 33 | 2008 |
Current and potential treatments for ubiquitous but neglected herpesvirus infections JE Gable, TM Acker, CS Craik Chemical Reviews 114 (22), 11382-11412, 2014 | 31 | 2014 |
Fluorescence and UV resonance Raman study of peptide− vesicle interactions of human cathelicidin LL-37 and its F6W and F17W Mutants JE Gable, DE Schlamadinger, AL Cogen, RL Gallo, JE Kim Biochemistry 48 (47), 11264-11272, 2009 | 28 | 2009 |
An artificial intelligence approach to proactively inspire drug discovery with recommendations SL Rohall, L Auch, J Gable, J Gora, J Jansen, Y Lu, E Martin, ... Journal of medicinal chemistry 63 (16), 8824-8834, 2020 | 20 | 2020 |
Allosteric inhibitors, crystallography, and comparative analysis reveal network of coordinated movement across human herpesvirus proteases TM Acker, JE Gable, MF Bohn, P Jaishankar, MC Thompson, JS Fraser, ... Journal of the American Chemical Society 139 (34), 11650-11653, 2017 | 18 | 2017 |
Broad-spectrum allosteric inhibition of herpesvirus proteases JE Gable, GM Lee, P Jaishankar, BR Hearn, CA Waddling, AR Renslo, ... Biochemistry 53 (28), 4648-4660, 2014 | 18 | 2014 |
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections SPS Rao, MK Gould, J Noeske, M Saldivia, RS Jumani, PS Ng, O René, ... Science 380 (6652), 1349-1356, 2023 | 14 | 2023 |
Fragment‐Based Protein–Protein Interaction Antagonists of a Viral Dimeric Protease JE Gable, GM Lee, TM Acker, KR Hulce, ER Gonzalez, P Schweigler, ... ChemMedChem 11 (8), 862-869, 2016 | 12 | 2016 |
Discovery of novel quinoline-based proteasome inhibitors for Human African Trypanosomiasis (HAT) DC Koester, VM Marx, S Williams, J Jiricek, M Dauphinais, O René, ... Journal of medicinal chemistry 65 (17), 11776-11787, 2022 | 8 | 2022 |
Toxins and antimicrobial peptides: Interactions with membranes DE Schlamadinger, JE Gable, JE Kim Biosensing II 7397, 114-126, 2009 | 8 | 2009 |
Factor XIIa inhibitors AU Rao, BA McKittrick, M Lombardo, JD Hicks, AB McCracken, HD Chu, ... US Patent 10,875,851, 2020 | | 2020 |
AI-based recommendations for drug discovery N Stiefl, E Martin, W Shirley, J Jansen, J Gora, L Auch, S ROHALL, Y Lu, ... American Chemical Society SciMeetings 1 (2), 2020 | | 2020 |
DRUG DISCOVERY EFFORTS AND DEVELOPMENT OF KINETO-PLASTID ASSAYS AT NOVARTIS INSTITUTES FOR TROPICAL DISEASES L Pei, SM Concepcion, H Cheung, YL Chen, S Rao, S Williams, J Gable, ... TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE 113, S90-S90, 2019 | | 2019 |
Allosteric inhibition via two-step enzyme isomerization of human herpesvirus protease protein-protein interaction decreases viral infectivity of Kaposi's sarcoma-associated … T Acker, J Gable, M Bohn, P Jaishankar, A Renslo, C Craik ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 253, 2017 | | 2017 |
Developing protein-protein interaction inhibitors of the herpesvirus protease family JE Gable UCSF, 2015 | | 2015 |
Broad-spectrum allosteric inhibition of herpesvirus proteases C Craik, A Renslo, JE Gable, GM Lee, P Jaishankar, BR Hearn, ... | | 2014 |