| Design of a novel globular protein fold with atomic-level accuracy B Kuhlman, G Dantas, GC Ireton, G Varani, BL Stoddard, D Baker science 302 (5649), 1364-1368, 2003 | 2064 | 2003 |
| De novo computational design of retro-aldol enzymes L Jiang, EA Althoff, FR Clemente, L Doyle, D Rothlisberger, A Zanghellini, ... science 319 (5868), 1387-1391, 2008 | 1414 | 2008 |
| Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction JB Siegel, A Zanghellini, HM Lovick, G Kiss, AR Lambert, JL St. Clair, ... Science 329 (5989), 309-313, 2010 | 1114 | 2010 |
| A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes RJ Roberts, M Belfort, T Bestor, AS Bhagwat, TA Bickle, J Bitinaite, ... Nucleic acids research 31 (7), 1805-1812, 2003 | 917 | 2003 |
| The crystal structure of TAL effector PthXo1 bound to its DNA target ANS Mak, P Bradley, RA Cernadas, AJ Bogdanove, BL Stoddard Science 335 (6069), 716-719, 2012 | 740 | 2012 |
| Homing endonuclease structure and function BL Stoddard Quarterly reviews of biophysics 38 (1), 49-95, 2005 | 706 | 2005 |
| Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility BS Chevalier, BL Stoddard Nucleic acids research 29 (18), 3757-3774, 2001 | 651 | 2001 |
| Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme WG Scott, JB Murray, JRP Arnold, BL Stoddard, A Klug Science 274 (5295), 2065-2069, 1996 | 590 | 1996 |
| The allosteric regulation of pyruvate kinase by fructose-1, 6-bisphosphate MS Jurica, A Mesecar, PJ Heath, W Shi, T Nowak, BL Stoddard Structure 6 (2), 195-210, 1998 | 517 | 1998 |
| Computational design of ligand-binding proteins with high affinity and selectivity CE Tinberg, SD Khare, J Dou, L Doyle, JW Nelson, A Schena, ... Nature 501 (7466), 212-216, 2013 | 489 | 2013 |
| Biocontainment of genetically modified organisms by synthetic protein design DJ Mandell, MJ Lajoie, MT Mee, R Takeuchi, G Kuznetsov, JE Norville, ... Nature 518 (7537), 55-60, 2015 | 477 | 2015 |
| Computational thermostabilization of an enzyme A Korkegian, ME Black, D Baker, BL Stoddard Science 308 (5723), 857-860, 2005 | 461 | 2005 |
| Computational redesign of endonuclease DNA binding and cleavage specificity J Ashworth, JJ Havranek, CM Duarte, D Sussman, RJ Monnat Jr, ... Nature 441 (7093), 656-659, 2006 | 442 | 2006 |
| Homing endonucleases: from microbial genetic invaders to reagents for targeted DNA modification BL Stoddard Structure 19 (1), 7-15, 2011 | 404 | 2011 |
| Structure of the C2 domain of human factor VIII at 1.5 Å resolution KP Pratt, BW Shen, K Takeshima, EW Davie, K Fujikawa, BL Stoddard Nature 402 (6760), 439-442, 1999 | 404 | 1999 |
| Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels AL Perraud, CL Takanishi, B Shen, S Kang, MK Smith, C Schmitz, ... Journal of Biological Chemistry 280 (7), 6138-6148, 2005 | 399 | 2005 |
| Computational redesign of protein-protein interaction specificity T Kortemme, LA Joachimiak, AN Bullock, AD Schuler, BL Stoddard, ... Nature structural & molecular biology 11 (4), 371-379, 2004 | 387 | 2004 |
| Increased Diels-Alderase activity through backbone remodeling guided by Foldit players CB Eiben, JB Siegel, JB Bale, S Cooper, F Khatib, BW Shen, F Players, ... Nature biotechnology 30 (2), 190-192, 2012 | 371 | 2012 |
| A synthetic sex ratio distortion system for the control of the human malaria mosquito R Galizi, LA Doyle, M Menichelli, F Bernardini, A Deredec, A Burt, ... Nature communications 5 (1), 3977, 2014 | 370 | 2014 |
| Computational protein design enables a novel one-carbon assimilation pathway JB Siegel, AL Smith, S Poust, AJ Wargacki, A Bar-Even, C Louw, ... Proceedings of the National Academy of Sciences 112 (12), 3704-3709, 2015 | 369 | 2015 |
David BakerUniversity of Washington在 uw.edu 的电子邮件经过验证
