In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells M Martinez-Lage, R Torres-Ruiz, P Puig-Serra, P Moreno-Gaona, ... Nature communications 11 (1), 5060, 2020 | 93 | 2020 |
Altered expression of the imprinted transcription factor PLAGL1 deregulates a network of genes in the human IUGR placenta I Iglesias-Platas, A Martin-Trujillo, P Petazzi, A Guillaumet-Adkins, ... Human molecular genetics 23 (23), 6275-6285, 2014 | 89 | 2014 |
Dysregulation of the long non-coding RNA transcriptome in a Rett syndrome mouse model P Petazzi, J Sandoval, K Szczesna, OC Jorge, L Roa, S Sayols, A Gomez, ... RNA biology 10 (7), 1197-1203, 2013 | 85 | 2013 |
Mutations in JMJD1C are involved in Rett syndrome and intellectual disability MA Sáez, J Fernández-Rodríguez, C Moutinho, JV Sanchez-Mut, ... Genetics in Medicine 18 (4), 378-385, 2016 | 57 | 2016 |
Inhibition of Gsk3b reduces Nfkb1 signaling and rescues synaptic activity to improve the Rett syndrome phenotype in Mecp2-knockout mice OC Jorge-Torres, K Szczesna, L Roa, C Casal, L Gonzalez-Somermeyer, ... Cell Reports 23 (6), 1665-1677, 2018 | 46 | 2018 |
Improvement of the rett syndrome phenotype in a mecp2 mouse model upon treatment with levodopa and a dopa-decarboxylase inhibitor K Szczesna, O De La Caridad, P Petazzi, M Soler, L Roa, MA Saez, ... Neuropsychopharmacology 39 (12), 2846-2856, 2014 | 36 | 2014 |
Circadian cycle-dependent MeCP2 and brain chromatin changes A Martinez de Paz, JV Sanchez-Mut, M Samitier-Martí, P Petazzi, M Sáez, ... PloS one 10 (4), e0123693, 2015 | 34 | 2015 |
A novel and efficient tandem CD19-and CD22-directed CAR for B cell ALL SR Zanetti, T Velasco-Hernandez, F Gutierrez-Agüera, VM Díaz, ... Molecular Therapy 30 (2), 550-563, 2022 | 29 | 2022 |
Profiling of oxBS-450K 5-hydroxymethylcytosine in human placenta and brain reveals enrichment at imprinted loci JR Hernandez Mora, M Sanchez-Delgado, P Petazzi, S Moran, M Esteller, ... Epigenetics 13 (2), 182-191, 2018 | 28 | 2018 |
An increase in MECP2 dosage impairs neural tube formation P Petazzi, N Akizu, A García, C Estarás, AM de Paz, ... Neurobiology of Disease 67, 49-56, 2014 | 28 | 2014 |
Generation and characterization of rat and mouse monoclonal antibodies specific for MeCP2 and their use in X-inactivation studies KL Jost, A Rottach, M Milden, B Bertulat, A Becker, P Wolf, J Sandoval, ... PloS one 6 (11), e26499, 2011 | 25 | 2011 |
Nitric oxide control of proliferation in nerve cells and in tumor cells of nervous origin E Pena-Altamira, P Petazzi, A Contestabile Current pharmaceutical design 16 (4), 440-450, 2010 | 24 | 2010 |
Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma C Recasens-Zorzo, T Cardesa-Salzmann, P Petazzi, L Ros-Blanco, ... haematologica 104 (4), 778, 2019 | 22 | 2019 |
Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia JR Tejedor, C Bueno, M Vinyoles, P Petazzi, A Agraz-Doblas, I Cobo, ... The Journal of Clinical Investigation 131 (13), 2021 | 15 | 2021 |
Generation of cholinergic and dopaminergic interneurons from human pluripotent stem cells as a relevant tool for in vitro modeling of neurological disorders pathology and therapy A Ochalek, K Szczesna, P Petazzi, J Kobolak, A Dinnyes Stem Cells International 2016 (1), 5838934, 2016 | 14 | 2016 |
Robustness of catalytically dead Cas9 activators in human pluripotent and mesenchymal stem cells P Petazzi, R Torres-Ruiz, A Fidanza, H Roca-Ho, F Gutierrez-Agüera, ... Molecular Therapy-Nucleic Acids 20, 196-204, 2020 | 13 | 2020 |
The hypomethylation of imprinted genes in IVF/ICSI placenta samples is associated with concomitant changes in histone modifications C Choux, P Petazzi, M Sanchez-Delgado, JR Hernandez Mora, ... Epigenetics 15 (12), 1386-1395, 2020 | 11 | 2020 |
Efficient elimination of primary B-ALL cells in vitro and in vivo using a novel 4-1BB-based CAR targeting a membrane-distal CD22 epitope T Velasco-Hernandez, SR Zanetti, H Roca-Ho, F Gutierrez-Aguera, ... Journal for immunotherapy of cancer 8 (2), 2020 | 11 | 2020 |
CRISPR/Cas9–mediated gene knockout and knockin human iPSCs P Petazzi, P Menéndez, A Sevilla Induced Pluripotent Stem (iPS) Cells: Methods and Protocols, 559-574, 2020 | 9 | 2020 |
ABO gene editing for the conversion of blood type A to universal type O in Rhnull donor‐derived human‐induced pluripotent stem cells P Petazzi, L Miquel‐Serra, S Huertas, C González, N Boto, E Muñiz‐Diaz, ... Clinical and Translational Medicine 12 (10), e1063, 2022 | 6 | 2022 |