Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins G Rappa, A Lorico, RA Flavell, AC Sartorelli Cancer research 57 (23), 5232-5237, 1997 | 375 | 1997 |
Disruption of the Murine MRP (Multidrug Resistance Protein) Gene Leads to Increased Sensitivity to Etoposide (VP-16) and Increased Levels of Glutathione A Lorico, G Rappa, RA Finch, D Yang, RA Flavell, AC Sartorelli Cancer research 57 (23), 5238-5242, 1997 | 330 | 1997 |
The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma G Rappa, O Fodstad, A Lorico Stem cells 26 (12), 3008-3017, 2008 | 316 | 2008 |
Clinical significance of extracellular vesicles in plasma from glioblastoma patients D Osti, M Del Bene, G Rappa, M Santos, V Matafora, C Richichi, S Faletti, ... Clinical Cancer Research 25 (1), 266-276, 2019 | 226 | 2019 |
Inhibitors of ribonucleotide reductase: Comparative effects of amino-and hydroxy-substituted pyridine-2-carboxaldehydethiosemicarbazones JG Cory, AH Cory, G Rappa, A Lorico, L Mao-Chin, L Tai-Shun, ... Biochemical pharmacology 48 (2), 335-344, 1994 | 141 | 1994 |
Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines BH Long, L Wang, A Lorico, RCC Wang, MG Brattain, AM Casazza Cancer Research 51 (19), 5275-5283, 1991 | 132 | 1991 |
Biochemical and biological characterization of exosomes containing prominin-1/CD133 G Rappa, J Mercapide, F Anzanello, RM Pope, A Lorico Molecular cancer 12, 1-17, 2013 | 118 | 2013 |
Double Knockout of the MRP Gene Leads to Increased Drug Sensitivity in Vitro A Lorico, G Rappa, RA Flavell, AC Sartorelli Cancer research 56 (23), 5351-5355, 1996 | 115 | 1996 |
Spontaneous formation of tumorigenic hybrids between breast cancer and multipotent stromal cells is a source of tumor heterogeneity G Rappa, J Mercapide, A Lorico The American journal of pathology 180 (6), 2504-2515, 2012 | 101 | 2012 |
Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth M Setti, D Osti, C Richichi, B Ortensi, M Del Bene, L Fornasari, ... Oncotarget 6 (31), 31413, 2015 | 98 | 2015 |
Breast cancer‐derived extracellular vesicles: characterization and contribution to the metastatic phenotype TM Green, ML Alpaugh, SH Barsky, G Rappa, A Lorico BioMed research international 2015 (1), 634865, 2015 | 96 | 2015 |
New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models. G Rappa, RA Finch, AC Sartorelli, A Lorico Biochemical pharmacology 58 (4), 557-562, 1999 | 96 | 1999 |
Phenotypic heterogeneity of breast cancer stem cells A Lorico, G Rappa Journal of oncology 2011 (1), 135039, 2011 | 94 | 2011 |
Accumulation of DNA Strand Breaks in Cells Exposed to Methotrexate or N10-Propargyl-5,8-dideazafolic Acid A Lorico, G Toffoli, M Boiocchi, E Erba, M Broggini, G Rappa, M D'Incalci Cancer Research 48 (8), 2036-2041, 1988 | 93 | 1988 |
Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells S Cisternino, C Rousselle, A Lorico, G Rappa, JM Scherrmann Pharmaceutical research 20, 904-909, 2003 | 92 | 2003 |
Growth of cancer cell lines under stem cell-like conditions has the potential to unveil therapeutic targets G Rappa, J Mercapide, F Anzanello, L Prasmickaite, Y Xi, J Ju, O Fodstad, ... Experimental cell research 314 (10), 2110-2122, 2008 | 88 | 2008 |
Erythrocyte membrane ATP binding cassette (ABC) proteins: MRP1 and CFTR as well as CD39 (ecto-apyrase) involved in RBC ATP transport and elevated blood plasma ATP of cystic … EH Abraham, KM Sterling, RJ Kim, AY Salikhova, HB Huffman, ... Blood Cells, Molecules, and Diseases 27 (1), 165-180, 2001 | 84 | 2001 |
VAMP-associated protein-A and oxysterol-binding protein–related protein 3 promote the entry of late endosomes into the nucleoplasmic reticulum MF Santos, G Rappa, J Karbanová, T Kurth, D Corbeil, A Lorico Journal of Biological Chemistry 293 (36), 13834-13848, 2018 | 69 | 2018 |
Extracellular vesicles as biological shuttles for targeted therapies S Raimondo, G Giavaresi, A Lorico, R Alessandro International journal of molecular sciences 20 (8), 1848, 2019 | 68 | 2019 |
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II A Lorico, BH Long European Journal of Cancer 29 (14), 1985-1991, 1993 | 66 | 1993 |