| Protein production and purification AF des Macromolécules Biologiques Vincentelli Renaud 4 Cambillau Christian 4 Nature methods 5 (2), 135-146, 2008 | 995* | 2008 |
| The promise and peril of chemical probes CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ... Nature chemical biology 11 (8), 536-541, 2015 | 841 | 2015 |
| Architecture of RNA polymerase II and implications for the transcription mechanism P Cramer, DA Bushnell, J Fu, AL Gnatt, B Maier-Davis, NE Thompson, ... science 288 (5466), 640-649, 2000 | 818 | 2000 |
| Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty Jr, ... Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006 | 726 | 2006 |
| Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA A Bochkarev, RA Pfuetzner, AM Edwards, L Frappier Nature 385 (6612), 176-181, 1997 | 723 | 1997 |
| Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection L Chen, I Borozan, J Feld, J Sun, LL Tannis, C Coltescu, J Heathcote, ... Gastroenterology 128 (5), 1437-1444, 2005 | 571 | 2005 |
| A proposal for validation of antibodies M Uhlen, A Bandrowski, S Carr, A Edwards, J Ellenberg, E Lundberg, ... Nature methods 13 (10), 823-827, 2016 | 560 | 2016 |
| A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ... Nature chemical biology 7 (8), 566-574, 2011 | 554 | 2011 |
| A call for systematic research on solute carriers A Cesar-Razquin, B Snijder, T Frappier-Brinton, R Isserlin, G Gyimesi, ... Cell 162 (3), 478-487, 2015 | 551 | 2015 |
| Too many roads not taken AM Edwards, R Isserlin, GD Bader, SV Frye, TM Willson, FH Yu Nature 470 (7333), 163-165, 2011 | 441 | 2011 |
| Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1: implications for EBV-mediated immortalization V Saridakis, Y Sheng, F Sarkari, MN Holowaty, K Shire, T Nguyen, ... Molecular cell 18 (1), 25-36, 2005 | 437 | 2005 |
| Structural proteomics of an archaeon D Christendat, A Yee, A Dharamsi, Y Kluger, A Savchenko, JR Cort, ... Nature structural biology 7 (10), 903-909, 2000 | 417 | 2000 |
| Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family E Kuznetsova, M Proudfoot, CF Gonzalez, G Brown, MV Omelchenko, ... Journal of Biological Chemistry 281 (47), 36149-36161, 2006 | 360 | 2006 |
| Bridging structural biology and genomics: assessing protein interaction data with known complexes AM Edwards, B Kus, R Jansen, D Greenbaum, J Greenblatt, M Gerstein TRENDS in Genetics 18 (10), 529-536, 2002 | 359 | 2002 |
| A dual function of the CRISPR–Cas system in bacterial antivirus immunity and DNA repair M Babu, N Beloglazova, R Flick, C Graham, T Skarina, B Nocek, ... Molecular microbiology 79 (2), 484-502, 2011 | 354 | 2011 |
| Herpes simplex virus triggers and then disarms a host antiviral response KL Mossman, PF Macgregor, JJ Rozmus, AB Goryachev, AM Edwards, ... Journal of virology 75 (2), 750-758, 2001 | 332 | 2001 |
| Two dissociable subunits of yeast RNA polymerase II stimulate the initiation of transcription at a promoter in vitro. AM Edwards, CM Kane, RA Young, RD Kornberg Journal of Biological Chemistry 266 (1), 71-75, 1991 | 331 | 1991 |
| Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA G Mer, A Bochkarev, R Gupta, E Bochkareva, L Frappier, CJ Ingles, ... Cell 103 (3), 449-456, 2000 | 319 | 2000 |
| Structure and biochemical functions of SIRT6 PW Pan, JL Feldman, MK Devries, A Dong, AM Edwards, JM Denu Journal of Biological Chemistry 286 (16), 14575-14587, 2011 | 317 | 2011 |
| Crystal structure of the CorA Mg2+ transporter VV Lunin, E Dobrovetsky, G Khutoreskaya, R Zhang, A Joachimiak, ... Nature 440 (7085), 833-837, 2006 | 313 | 2006 |
