The emerging role of epigenetics in human autoimmune disorders R Mazzone, C Zwergel, M Artico, S Taurone, M Ralli, A Greco, A Mai Clinical epigenetics 11, 1-15, 2019 | 253 | 2019 |
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy R Mazzone, C Zwergel, A Mai, S Valente Clinical epigenetics 9 (1), 59, 2017 | 145 | 2017 |
Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells S Valente, Y Liu, M Schnekenburger, C Zwergel, S Cosconati, C Gros, ... Journal of medicinal chemistry 57 (3), 701-713, 2014 | 125 | 2014 |
Six years (2012–2018) of researches on catalytic ezh2 inhibitors: the boom of the 2‐pyridone compounds R Fioravanti, G Stazi, C Zwergel, S Valente, A Mai The Chemical Record 18 (12), 1818-1832, 2018 | 102 | 2018 |
Aurones: interesting natural and synthetic compounds with emerging biological potential C Zwergel, F Gaascht, S Valente, M Diederich, D Bagrel, G Kirsch Natural product communications 7 (3), 1934578X1200700322, 2012 | 98 | 2012 |
The innovative potential of statins in cancer: new targets for new therapies E Di Bello, C Zwergel, A Mai, S Valente Frontiers in chemistry 8, 516, 2020 | 95 | 2020 |
1, 4-Dihydropyridines active on the SIRT1/AMPK pathway ameliorate skin repair and mitochondrial function and exhibit inhibition of proliferation in cancer cells S Valente, P Mellini, F Spallotta, V Carafa, A Nebbioso, L Polletta, ... Journal of Medicinal Chemistry 59 (4), 1471-1491, 2016 | 76 | 2016 |
Emerging approaches for histone deacetylase inhibitor drug discovery C Zwergel, S Valente, C Jacob, A Mai Expert opinion on drug discovery 10 (6), 599-613, 2015 | 76 | 2015 |
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells G Di Pompo, M Salerno, D Rotili, S Valente, C Zwergel, S Avnet, ... Journal of medicinal chemistry 58 (9), 4073-4079, 2015 | 75 | 2015 |
DNA methyltransferases inhibitors from natural sources C Zwergel, S Valente, A Mai Current topics in medicinal chemistry 16 (7), 680-696, 2016 | 67 | 2016 |
m6A RNA methylation and beyond–The epigenetic machinery and potential treatment options S Garbo, C Zwergel, C Battistelli Drug discovery today 26 (11), 2559-2574, 2021 | 63 | 2021 |
The innovative potential of selenium-containing agents for fighting cancer and viral infections W Ali, R Benedetti, J Handzlik, C Zwergel, C Battistelli Drug Discovery Today 26 (1), 256-263, 2021 | 62 | 2021 |
Histone deacetylase inhibitors: updated studies in various epigenetic-related diseases C Zwergel, G Stazi, S Valente, A Mai J Clin Epigenetics 2 (1), 7, 2016 | 60 | 2016 |
LSD1 inhibitors: a patent review (2010-2015) G Stazi, C Zwergel, S Valente, A Mai Expert Opinion on Therapeutic Patents 26 (5), 565-580, 2016 | 58 | 2016 |
EZH2 inhibitors: a patent review (2014-2016) G Stazi, C Zwergel, A Mai, S Valente Expert opinion on therapeutic patents 27 (7), 797-813, 2017 | 55 | 2017 |
Novel benzofuran–chromone and–coumarin derivatives: synthesis and biological activity in K562 human leukemia cells C Zwergel, S Valente, A Salvato, Z Xu, O Talhi, A Mai, A Silva, L Altucci, ... MedChemComm 4 (12), 1571-1579, 2013 | 54 | 2013 |
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells E Miele, S Valente, V Alfano, M Silvano, P Mellini, D Borovika, B Marrocco, ... Oncotarget 8 (40), 68557, 2017 | 52 | 2017 |
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells A Romanelli, G Stazi, R Fioravanti, C Zwergel, E Di Bello, S Pomella, ... ACS medicinal chemistry letters 11 (5), 977-983, 2020 | 51 | 2020 |
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019 N Mautone, C Zwergel, A Mai, D Rotili Expert Opinion on Therapeutic Patents 30 (6), 389-407, 2020 | 49 | 2020 |
Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines C Seidel, M Schnekenburger, C Zwergel, F Gaascht, A Mai, M Dicato, ... Bioorganic & Medicinal Chemistry Letters 24 (16), 3797-3801, 2014 | 48 | 2014 |