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Dennis Ko
Dennis Ko
Assoc. Professor of Molecular Genetics and Microbiology, Duke University
在 duke.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections
DM Tobin, FJ Roca, SF Oh, R McFarland, TW Vickery, JP Ray, DC Ko, ...
Cell 148 (3), 434-446, 2012
6522012
Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease
DC Ko, L Milenkovic, SM Beier, H Manuel, JA Buchanan, MP Scott
PLoS genetics 1 (1), e7, 2005
2752005
Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events
DC Ko, MD Gordon, JY Jin, MP Scott
Molecular biology of the cell 12 (3), 601-614, 2001
2742001
The integrity of a cholesterol-binding pocket in Niemann–Pick C2 protein is necessary to control lysosome cholesterol levels
DC Ko, J Binkley, A Sidow, MP Scott
Proceedings of the National Academy of Sciences 100 (5), 2518-2525, 2003
2552003
Binding between the Niemann–Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain
N Ohgami, DC Ko, M Thomas, MP Scott, CCY Chang, TY Chang
Proceedings of the National Academy of Sciences 101 (34), 12473-12478, 2004
2522004
Antitermination by bacteriophage λ Q protein
JW Roberts, W Yarnell, E Bartlett, J Guo, M Marr, DC Ko, H Sun, ...
Cold Spring Harbor symposia on quantitative biology 63, 319-326, 1998
1891998
Analysis of a Food-Borne Fungal Pathogen Outbreak: Virulence and Genome of a Mucor circinelloides Isolate from Yogurt
SC Lee, RB Billmyre, A Li, S Carson, SM Sykes, EY Huh, P Mieczkowski, ...
MBio 5 (4), 10.1128/mbio. 01390-14, 2014
1342014
Human epistatic interaction controls IL7R splicing and increases multiple sclerosis risk
G Galarza-Muñoz, FBS Briggs, I Evsyukova, G Schott-Lerner, ...
Cell 169 (1), 72-84. e13, 2017
1152017
A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease
DC Ko, KP Shukla, C Fong, M Wasnick, MJ Brittnacher, MM Wurfel, ...
The American Journal of Human Genetics 85 (2), 214-227, 2009
962009
Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host–pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides
SC Lee, A Li, S Calo, M Inoue, NK Tonthat, JM Bain, J Louw, ...
Molecular microbiology 97 (5), 844-865, 2015
932015
A surface of Escherichia coli sigma 70 required for promoter function and antitermination by phage lambda Q protein.
K DC, M MT, G J, R JW.
Genes & Development 12 (20), 3276-85, 1998
761998
Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death
DC Ko, ER Gamazon, KP Shukla, RA Pfuetzner, D Whittington, TD Holden, ...
Proceedings of the National Academy of Sciences 109 (35), E2343-E2352, 2012
752012
Salmonella activation of STAT3 signaling by SarA effector promotes intracellular replication and production of IL-10
SL Jaslow, KD Gibbs, WF Fricke, L Wang, KJ Pittman, MK Mammel, ...
Cell reports 23 (12), 3525-3536, 2018
722018
An Enzyme That Inactivates the Inflammatory Mediator Leukotriene B4 Restricts Mycobacterial Infection
DM Tobin, FJ Roca, JP Ray, DC Ko, L Ramakrishnan
PloS one 8 (7), e67828, 2013
642013
The Salmonella secreted effector SarA/SteE mimics cytokine receptor signaling to activate STAT3
KD Gibbs, EJ Washington, SL Jaslow, JS Bourgeois, MW Foster, R Guo, ...
Cell host & microbe 27 (1), 129-139. e4, 2020
622020
Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis
L Wang, ER Ko, JJ Gilchrist, KJ Pittman, A Rautanen, M Pirinen, ...
Science Advances 3 (3), e1602096, 2017
572017
Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol
MI Alvarez, LC Glover, P Luo, L Wang, E Theusch, SH Oehlers, ...
Proceedings of the National Academy of Sciences 114 (37), E7746-E7755, 2017
552017
An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility
L Wang, TJ Balmat, AL Antonia, FJ Constantine, R Henao, TW Burke, ...
Genome medicine 13 (1), 83, 2021
542021
An atlas of genetic variation linking pathogen-induced cellular traits to human disease
L Wang, KJ Pittman, JR Barker, RE Salinas, IB Stanaway, GD Williams, ...
Cell host & microbe 24 (2), 308-323. e6, 2018
542018
Multiple surface regions on the Niemann-Pick C2 protein facilitate intracellular cholesterol transport
LA McCauliff, Z Xu, R Li, S Kodukula, DC Ko, MP Scott, PC Kahn, J Storch
Journal of Biological Chemistry 290 (45), 27321-27331, 2015
512015
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