A cross-population atlas of genetic associations for 220 human phenotypes S Sakaue, M Kanai, Y Tanigawa, J Karjalainen, M Kurki, S Koshiba, ... Nature genetics 53 (10), 1415-1424, 2021 | 861 | 2021 |
Genetics of 35 blood and urine biomarkers in the UK Biobank N Sinnott-Armstrong, Y Tanigawa, D Amar, N Mars, C Benner, M Aguirre, ... Nature genetics 53 (2), 185-194, 2021 | 514 | 2021 |
Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval EA King, JW Davis, JF Degner PLoS genetics 15 (12), e1008489, 2019 | 490 | 2019 |
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers N Mars, JT Koskela, P Ripatti, TTJ Kiiskinen, AS Havulinna, JV Lindbohm, ... Nature medicine 26 (4), 549-557, 2020 | 336 | 2020 |
Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing KH Taylor, RS Kramer, JW Davis, J Guo, DJ Duff, D Xu, CW Caldwell, ... Cancer research 67 (18), 8511-8518, 2007 | 330 | 2007 |
Effects of vendor and genetic background on the composition of the fecal microbiota of inbred mice AC Ericsson, JW Davis, W Spollen, N Bivens, S Givan, CE Hagan, ... PloS one 10 (2), e0116704, 2015 | 328 | 2015 |
Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank JD Szustakowski, S Balasubramanian, E Kvikstad, S Khalid, PG Bronson, ... Nature Genetics 53 (7), 942-948, 2021 | 302 | 2021 |
Rare variant contribution to human disease in 281,104 UK Biobank exomes Q Wang, RS Dhindsa, K Carss, AR Harper, A Nag, I Tachmazidou, ... Nature 597 (7877), 527-532, 2021 | 273 | 2021 |
Estrogen and androgen receptor activities of hydraulic fracturing chemicals and surface and ground water in a drilling-dense region CD Kassotis, DE Tillitt, JW Davis, AM Hormann, SC Nagel Endocrinology 155 (3), 897-907, 2014 | 237 | 2014 |
Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia KH Taylor, KE Pena-Hernandez, JW Davis, GL Arthur, DJ Duff, H Shi, ... Cancer research 67 (6), 2617-2625, 2007 | 173 | 2007 |
Genetic architecture of human plasma lipidome and its link to cardiovascular disease R Tabassum, JT Rämö, P Ripatti, JT Koskela, M Kurki, J Karjalainen, ... Nature communications 10 (1), 4329, 2019 | 148 | 2019 |
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection Nature Medicine 27, 1012–1024, 2021 | 125 | 2021 |
Sleep apnoea is a risk factor for severe COVID-19 S Strausz, T Kiiskinen, M Broberg, S Ruotsalainen, J Koskela, A Bachour, ... Bmj open respiratory research 8 (1), e000845, 2021 | 120 | 2021 |
Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes KJ Karczewski, M Solomonson, KR Chao, JK Goodrich, G Tiao, W Lu, ... Cell Genomics 2 (9), 2022 | 115 | 2022 |
Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health S Strausz, S Ruotsalainen, HM Ollila, J Karjalainen, T Kiiskinen, M Reeve, ... European Respiratory Journal 57 (5), 2021 | 113 | 2021 |
The role of polygenic risk and susceptibility genes in breast cancer over the course of life N Mars, E Widén, S Kerminen, T Meretoja, M Pirinen, ... Nature communications 11 (1), 6383, 2020 | 112 | 2020 |
The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells B Morin, LNA Nichols, KM Zalasky, JW Davis, JA Manthey, LJ Holland The Journal of nutrition 138 (7), 1274-1281, 2008 | 107 | 2008 |
Differential DNA methylation patterns of small B-cell lymphoma subclasses with different clinical behavior FB Rahmatpanah, S Carstens, J Guo, O Sjahputera, KH Taylor, D Duff, ... Leukemia 20 (10), 1855-1862, 2006 | 103 | 2006 |
Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan S Sakaue, M Kanai, J Karjalainen, M Akiyama, M Kurki, N Matoba, ... Nature medicine 26 (4), 542-548, 2020 | 96 | 2020 |
Polygenic risk scores predict hypertension onset and cardiovascular risk F Vaura, A Kauko, K Suvila, AS Havulinna, N Mars, V Salomaa, FinnGen, ... Hypertension 77 (4), 1119-1127, 2021 | 94 | 2021 |