Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs AH Schinkel, JJM Smit, O van Tellingen, JH Beijnen, E Wagenaar, ... Cell 77 (4), 491-502, 1994 | 2746 | 1994 |
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins AH Schinkel, U Mayer, E Wagenaar, CAAM Mol, L Van Deemter, JJM Smit, ... Proceedings of the National Academy of Sciences 94 (8), 4028-4033, 1997 | 1186 | 1997 |
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine A Sparreboom, J Van Asperen, U Mayer, AH Schinkel, JW Smit, ... Proceedings of the National Academy of Sciences 94 (5), 2031-2035, 1997 | 1122 | 1997 |
Overcoming the blood–brain tumor barrier for effective glioblastoma treatment O Van Tellingen, B Yetkin-Arik, MC De Gooijer, P Wesseling, T Wurdinger, ... Drug Resistance Updates 19, 1-12, 2015 | 928 | 2015 |
Potent and Specific Inhibition of the Breast Cancer Resistance Protein Multidrug Transporter in Vitro and in Mouse Intestine by a Novel Analogue of Fumitremorgin C JD Allen, A Van Loevezijn, JM Lakhai, M Van Der Valk, O Van Tellingen, ... Molecular cancer therapeutics 1 (6), 417-425, 2002 | 895 | 2002 |
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. GJ Zaman, J Lankelma, O vAN Tellingen, J Beijnen, H Dekker, ... Proceedings of the National Academy of Sciences 92 (17), 7690-7694, 1995 | 646 | 1995 |
The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein … P Breedveld, D Pluim, G Cipriani, P Wielinga, O van Tellingen, ... Cancer research 65 (7), 2577-2582, 2005 | 446 | 2005 |
Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin B Pang, X Qiao, L Janssen, A Velds, T Groothuis, R Kerkhoven, ... Nature communications 4 (1), 1908, 2013 | 444 | 2013 |
Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure JW Smit, MT Huisman, O van Tellingen, HR Wiltshire, AH Schinkel The Journal of clinical investigation 104 (10), 1441-1447, 1999 | 432 | 1999 |
Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL A Sparreboom, O van Tellingen, WJ Nooijen, JH Beijnen Cancer research 56 (9), 2112-2115, 1996 | 389 | 1996 |
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer S Rottenberg, AOH Nygren, M Pajic, FWB van Leeuwen, ... Proceedings of the National Academy of Sciences 104 (29), 12117-12122, 2007 | 366 | 2007 |
Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma SWM Bruggeman, D Hulsman, E Tanger, T Buckle, M Blom, ... Cancer cell 12 (4), 328-341, 2007 | 334 | 2007 |
P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan NA de Vries, J Zhao, E Kroon, T Buckle, JH Beijnen, O Van Tellingen Clinical Cancer Research 13 (21), 6440-6449, 2007 | 316 | 2007 |
Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein EM Kemper, AE van Zandbergen, C Cleypool, HA Mos, W Boogerd, ... Clinical Cancer Research 9 (7), 2849-2855, 2003 | 309 | 2003 |
Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions P Breedveld, N Zelcer, D Pluim, O Sönmezer, MM Tibben, JH Beijnen, ... Cancer Research 64 (16), 5804-5811, 2004 | 283 | 2004 |
Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101) PJ Gaillard, CCM Appeldoorn, R Dorland, J Van Kregten, F Manca, ... PloS one 9 (1), e82331, 2014 | 282 | 2014 |
Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat R Seigers, SB Schagen, W Beerling, W Boogerd, O Van Tellingen, ... Behavioural brain research 186 (2), 168-175, 2008 | 276 | 2008 |
Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: pharmacokinetics and cisplatin–DNA adduct formation in patients and ovarian cancer cell lines PJM Van de Vaart, N Van der Vange, FAN Zoetmulder, AR Van Goethem, ... European journal of cancer 34 (1), 148-154, 1998 | 276 | 1998 |
Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833 J Van Asperen, O Van Tellingen, A Sparreboom, AH Schinkel, P Borst, ... British journal of cancer 76 (9), 1181-1183, 1997 | 261 | 1997 |
Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism AE van Herwaarden, E Wagenaar, CMM van der Kruijssen, ... The Journal of clinical investigation 117 (11), 3583-3592, 2007 | 260 | 2007 |