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Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765 SEM Herman, AL Gordon, E Hertlein, A Ramanunni, X Zhang, ... Blood, The Journal of the American Society of Hematology 117 (23), 6287-6296, 2011 | 1000 | 2011 |
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival … SEM Herman, AL Gordon, AJ Wagner, NA Heerema, W Zhao, JM Flynn, ... Blood, The Journal of the American Society of Hematology 116 (12), 2078-2088, 2010 | 732 | 2010 |
TGF-β utilizes SMAD3 to inhibit CD16-mediated IFN-γ production and antibody-dependent cellular cytotoxicity in human NK cells R Trotta, JD Col, J Yu, D Ciarlariello, B Thomas, X Zhang, J Allard, M Wei, ... The Journal of Immunology 181 (6), 3784-3792, 2008 | 278 | 2008 |
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Ibrutinib antagonizes rituximab-dependent NK cell–mediated cytotoxicity HE Kohrt, I Sagiv-Barfi, S Rafiq, SEM Herman, JP Butchar, C Cheney, ... Blood, The Journal of the American Society of Hematology 123 (12), 1957-1960, 2014 | 237 | 2014 |
The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo DM Lucas, RB Edwards, G Lozanski, DA West, JD Shin, MA Vargo, ... Blood, The Journal of the American Society of Hematology 113 (19), 4656-4666, 2009 | 225 | 2009 |
Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells AK Srivastava, C Han, R Zhao, T Cui, Y Dai, C Mao, W Zhao, X Zhang, ... Proceedings of the National Academy of Sciences 112 (14), 4411-4416, 2015 | 201 | 2015 |
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A progenitor cell expressing transcription factor RORγt generates all human innate lymphoid cell subsets SD Scoville, BL Mundy-Bosse, MH Zhang, L Chen, X Zhang, KA Keller, ... Immunity 44 (5), 1140-1150, 2016 | 198 | 2016 |
Molecular characterization demonstrates that the Zea mays gene sugary2 codes for the starch synthase isoform SSIIa X Zhang, C Colleoni, V Ratushna, M Sirghie-Colleoni, M James, A Myers Plant molecular biology 54, 865-879, 2004 | 188 | 2004 |
Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma F Yan, L Alinari, ME Lustberg, L Katherine Martin, HM Cordero-Nieves, ... Cancer research 74 (6), 1752-1765, 2014 | 174 | 2014 |
Mutations affecting starch synthase III in Arabidopsis alter leaf starch structure and increase the rate of starch synthesis X Zhang, AM Myers, MG James Plant physiology 138 (2), 663-674, 2005 | 169 | 2005 |
RAGE mediates S100A7-induced breast cancer growth and metastasis by modulating the tumor microenvironment MW Nasser, NA Wani, DK Ahirwar, CA Powell, J Ravi, M Elbaz, H Zhao, ... Cancer research 75 (6), 974-985, 2015 | 148 | 2015 |
Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH17 cytokine interleukin-22 T Hughes, B Becknell, S McClory, E Briercheck, AG Freud, X Zhang, ... Blood, The Journal of the American Society of Hematology 113 (17), 4008-4010, 2009 | 144 | 2009 |
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Blocking the CCL2–CCR2 axis using CCL2-neutralizing antibody is an effective therapy for hepatocellular cancer in a mouse model KY Teng, J Han, X Zhang, SH Hsu, S He, NA Wani, JM Barajas, ... Molecular cancer therapeutics 16 (2), 312-322, 2017 | 131 | 2017 |
The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia SEM Herman, R Lapalombella, AL Gordon, A Ramanunni, KA Blum, ... Blood, The Journal of the American Society of Hematology 117 (16), 4323-4327, 2011 | 131 | 2011 |
17-DMAG targets the nuclear factor-κB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition E Hertlein, AJ Wagner, J Jones, TS Lin, KJ Maddocks, WH Towns III, ... Blood, The Journal of the American Society of Hematology 116 (1), 45-53, 2010 | 130 | 2010 |
IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic … A Gowda, J Roda, SRA Hussain, A Ramanunni, T Joshi, S Schmidt, ... Blood, The Journal of the American Society of Hematology 111 (9), 4723-4730, 2008 | 126 | 2008 |