| PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation G Ronson, AL Piberger, M Higgs, A Olsen, G Stewart, P McHugh, ... Nature Communications, 243071, 2018 | 213 | 2018 |
| BOD1L is required to suppress deleterious resection of stressed replication forks MR Higgs, JJ Reynolds, A Winczura, AN Blackford, V Borel, ES Miller, ... Molecular cell 59 (3), 462-477, 2015 | 201 | 2015 |
| Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice H Lerat, HL Kammoun, I Hainault, E Mérour, MR Higgs, C Callens, ... Journal of Biological Chemistry 284 (48), 33466-33474, 2009 | 111 | 2009 |
| Hepatitis C virus-induced activation of β-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events MR Higgs, H Lerat, JM Pawlotsky Oncogene 32 (39), 4683-4693, 2013 | 106 | 2013 |
| Histone methylation by SETD1A protects nascent DNA through the nucleosome chaperone activity of FANCD2 MR Higgs, K Sato, JJ Reynolds, S Begum, R Bayley, A Goula, A Vernet, ... Molecular cell 71 (1), 25-41. e6, 2018 | 103 | 2018 |
| ‘Liver let die’: oxidative DNA damage and hepatotropic viruses MR Higgs, P Chouteau, H Lerat Journal of General Virology 95 (5), 991-1004, 2014 | 101 | 2014 |
| Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism JJ Reynolds, LS Bicknell, P Carroll, MR Higgs, R Shaheen, JE Murray, ... Nature genetics 49 (4), 537-549, 2017 | 100 | 2017 |
| TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism ME Harley, O Murina, A Leitch, MR Higgs, LS Bicknell, G Yigit, ... Nature genetics 48 (1), 36-43, 2016 | 93 | 2016 |
| Downregulation of Gadd45β expression by hepatitis C virus leads to defective cell cycle arrest MR Higgs, H Lerat, JM Pawlotsky Cancer research 70 (12), 4901-4911, 2010 | 71 | 2010 |
| Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome J Kummeling, DE Stremmelaar, N Raun, MRF Reijnders, MH Willemsen, ... Molecular psychiatry 26 (6), 2013-2024, 2021 | 55 | 2021 |
| Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M J Wang, P Rojas, J Mao, MM Sadurnì, O Garnier, S Xiao, MR Higgs, ... Cell Reports 34 (7), 2021 | 37 | 2021 |
| The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centres MR Higgs, VG Preston, ND Stow Journal of general virology 89 (7), 1709-1715, 2008 | 35 | 2008 |
| Regulation of hepatitis C virus replication by nuclear translocation of nonstructural 5A protein and transcriptional activation of host genes MA Maqbool, MR Imache, MR Higgs, S Carmouse, JM Pawlotsky, H Lerat Journal of virology 87 (10), 5523-5539, 2013 | 34 | 2013 |
| Mutational analysis of the herpes simplex virus type 1 DNA packaging protein UL33 F Beilstein, MR Higgs, ND Stow Journal of virology 83 (17), 8938-8945, 2009 | 33 | 2009 |
| Hepatitis C virus induces a prediabetic state by directly impairing hepatic glucose metabolism in mice H Lerat, MR Imache, J Polyte, A Gaudin, M Mercey, F Donati, ... Journal of Biological Chemistry 292 (31), 12860-12873, 2017 | 30 | 2017 |
| Animal models in the study of hepatitis C virus-associated liver pathologies H Lerat, M Higgs, JM Pawlotsky Expert review of gastroenterology & hepatology 5 (3), 341-352, 2011 | 30 | 2011 |
| Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability R Zarrizi, MR Higgs, K Voßgröne, M Rossing, B Bertelsen, M Bose, ... The Journal of clinical investigation 130 (8), 4069-4080, 2020 | 29 | 2020 |
| Cancer therapy and replication stress: forks on the road to perdition P Kotsantis, RM Jones, MR Higgs, E Petermann Advances in clinical chemistry 69, 91-138, 2015 | 29 | 2015 |
| Bi-allelic variants in TONSL cause SPONASTRIME dysplasia and a spectrum of skeletal dysplasia phenotypes LC Burrage, JJ Reynolds, NV Baratang, JB Phillips, J Wegner, ... The American Journal of Human Genetics 104 (3), 422-438, 2019 | 28 | 2019 |
| A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis PAC Wing, T Davenne, J Wettengel, AG Lai, X Zhuang, A Chakraborty, ... Life science alliance 2 (2), 2019 | 27 | 2019 |
