| Structure of human dCK suggests strategies to improve anticancer and antiviral therapy E Sabini, S Ort, C Monnerjahn, M Konrad, A Lavie Nature Structural & Molecular Biology 10 (7), 513-519, 2003 | 216 | 2003 |
| The bottleneck in AZT activation A Lavie, I Schlichting, IR Vetter, M Konrads, J Reinstein, RS Goody Nature medicine 3 (8), 922-924, 1997 | 184 | 1997 |
| Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surface Y Li, AS Fanning, JM Anderson, A Lavie Journal of molecular biology 352 (1), 151-164, 2005 | 167 | 2005 |
| X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis A Lavie, KN Allen, GA Petsko, D Ringe Biochemistry 33 (18), 5469-5480, 1994 | 153 | 1994 |
| Therapeutic target metabolism observed using hyperpolarized 15N choline C Gabellieri, S Reynolds, A Lavie, GS Payne, MO Leach, TR Eykyn Journal of the American Chemical Society 130 (14), 4598-4599, 2008 | 152 | 2008 |
| Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation. A Lavie, IR Vetter, M Konrad, RS Goody, J Reinstein, I Schlichting Nature structural biology 4, 601-604, 1997 | 144 | 1997 |
| The TRAPP complex: insights into its architecture and function M Sacher, YG Kim, A Lavie, BH Oh, N Segev Traffic 9 (12), 2032-2042, 2008 | 143 | 2008 |
| Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate N Ostermann, I Schlichting, R Brundiers, M Konrad, J Reinstein, T Veit, ... Structure 8 (6), 629-642, 2000 | 133 | 2000 |
| Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy T Sato, A Neschadim, M Konrad, DH Fowler, A Lavie, JA Medin Molecular Therapy 15 (5), 962-970, 2007 | 132 | 2007 |
| Structural basis for efficient phosphorylation of 3′-azidothymidine monophosphate by Escherichia coli thymidylate kinase A Lavie, N Ostermann, R Brundiers, RS Goody, J Reinstein, M Konrad, ... Proceedings of the National Academy of Sciences 95 (24), 14045-14050, 1998 | 111 | 1998 |
| A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo HA Nguyen, Y Su, JY Zhang, A Antanasijevic, M Caffrey, AM Schalk, L Liu, ... Cancer research 78 (6), 1549-1560, 2018 | 96 | 2018 |
| Structural characterization of the closed conformation of mouse guanylate kinase N Sekulic, L Shuvalova, O Spangenberg, M Konrad, A Lavie Journal of Biological Chemistry 277 (33), 30236-30243, 2002 | 96 | 2002 |
| Isotopic exchange plus substrate and inhibition kinetics of D-xylose isomerase do not support a proton-transfer mechanism KN Allen, A Lavie, GK Farber, A Glasfeld, GA Petsko, D Ringe Biochemistry 33 (6), 1481-1487, 1994 | 95 | 1994 |
| Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine E Malito, N Sekulic, WCS Too, M Konrad, A Lavie Journal of molecular biology 364 (2), 136-151, 2006 | 92 | 2006 |
| Modifying human thymidylate kinase to potentiate azidothymidine activation R Brundiers, A Lavie, T Veit, J Reinstein, I Schlichting, N Ostermann, ... Journal of Biological Chemistry 274 (50), 35289-35292, 1999 | 92 | 1999 |
| Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid KN Allen, A Lavie, A Glasfeld, TN Tanada, DP Gerrity, SC Carlson, ... Biochemistry 33 (6), 1488-1494, 1994 | 92 | 1994 |
| Crystal Structure of Yeast Thymidylate Kinase Complexed with the Bisubstrate Inhibitor P1-(5‘-Adenosyl) P5-(5‘-Thymidyl) Pentaphosphate (TP5A) at 2.0 Å Resolution … A Lavie, M Konrad, R Brundiers, RS Goody, I Schlichting, J Reinstein Biochemistry 37 (11), 3677-3686, 1998 | 88 | 1998 |
| [18F] CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity W Kim, TM Le, L Wei, S Poddar, J Bazzy, X Wang, NT Uong, ER Abt, ... Proceedings of the National Academy of Sciences 113 (15), 4027-4032, 2016 | 84 | 2016 |
| The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1 J Nomme, AS Fanning, M Caffrey, MF Lye, JM Anderson, A Lavie Journal of Biological Chemistry 286 (50), 43352-43360, 2011 | 82 | 2011 |
| Design and characterization of Erwinia chrysanthemi L-asparaginase variants with diminished L-glutaminase activity HA Nguyen, Y Su, A Lavie Journal of Biological Chemistry 291 (34), 17664-17676, 2016 | 76 | 2016 |
