Linkage disequilibrium mapping identifies a 390 kb region associated with CYP2D6 poor drug metabolising activity LK Hosking, PR Boyd, CF Xu, M Nissum, K Cantone, IJ Purvis, R Khakhar, ... The Pharmacogenomics Journal 2 (3), 165-175, 2002 | 4976 | 2002 |
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs SH Lee, S Ripke, BM Neale, SV Faraone, SM Purcell, RH Perlis, ... Nature genetics 45 (9), 984-994, 2013 | 2346 | 2013 |
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma BE Johnson, T Mazor, C Hong, M Barnes, K Aihara, CY McLean, ... Science 343 (6167), 189-193, 2014 | 1434 | 2014 |
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits E Evangelou, HR Warren, D Mosen-Ansorena, B Mifsud, R Pazoki, H Gao, ... Nature genetics 50 (10), 1412-1425, 2018 | 1203 | 2018 |
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease H Li, S Wetten, L Li, PLS Jean, R Upmanyu, L Surh, D Hosford, ... Archives of neurology 65 (1), 45-53, 2008 | 595 | 2008 |
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk HR Warren, E Evangelou, CP Cabrera, H Gao, M Ren, B Mifsud, I Ntalla, ... Nature genetics 49 (3), 403-415, 2017 | 589 | 2017 |
Disruption of the neurexin 1 gene is associated with schizophrenia D Rujescu, A Ingason, S Cichon, OPH Pietiläinen, MR Barnes, ... Human molecular genetics 18 (5), 988-996, 2009 | 584 | 2009 |
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways B Devlin, JR Kelsoe, P Sklar, MJ Daly, MC O'Donovan, N Craddock, ... Nature neuroscience 18 (2), 199-209, 2015 | 522 | 2015 |
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis SE Baranzini, NW Galwey, J Wang, P Khankhanian, R Lindberg, ... Human molecular genetics 18 (11), 2078-2090, 2009 | 473 | 2009 |
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals GB Ehret, T Ferreira, DI Chasman, AU Jackson, EM Schmidt, T Johnson, ... Nature genetics 48 (10), 1171-1184, 2016 | 436 | 2016 |
Use of genome-wide association studies for drug repositioning P Sanseau, P Agarwal, MR Barnes, T Pastinen, JB Richards, LR Cardon, ... Nature biotechnology 30 (4), 317-320, 2012 | 417 | 2012 |
A mega-analysis of genome-wide association studies for major depressive disorder Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium Molecular psychiatry 18 (4), 2013 | 395 | 2013 |
Genome-wide pharmacogenetics of antidepressant response in the GENDEP project R Uher, N Perroud, MYM Ng, J Hauser, N Henigsberg, W Maier, O Mors, ... American Journal of Psychiatry 167 (5), 555-564, 2010 | 391 | 2010 |
Clinical applications of machine learning algorithms: beyond the black box DS Watson, J Krutzinna, IN Bruce, CEM Griffiths, IB McInnes, MR Barnes, ... Bmj 364, 2019 | 363 | 2019 |
Health and population effects of rare gene knockouts in adult humans with related parents VM Narasimhan, KA Hunt, D Mason, CL Baker, KJ Karczewski, ... Science 352 (6284), 474-477, 2016 | 318 | 2016 |
Molecular portraits of early rheumatoid arthritis identify clinical and treatment response phenotypes MJ Lewis, MR Barnes, K Blighe, K Goldmann, S Rana, JA Hackney, ... Cell reports 28 (9), 2455-2470. e5, 2019 | 290 | 2019 |
Genome-wide association study of major recurrent depression in the UK population CM Lewis, MY Ng, AW Butler, S Cohen-Woods, R Uher, K Pirlo, ... American Journal of Psychiatry 167 (8), 949-957, 2010 | 290 | 2010 |
Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization D Brömme, Z Li, M Barnes, E Mehler Biochemistry 38 (8), 2377-2385, 1999 | 281 | 1999 |
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins I Postmus, S Trompet, HA Deshmukh, MR Barnes, X Li, HR Warren, ... Nature communications 5 (1), 5068, 2014 | 279 | 2014 |
Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome HR Wong, TP Shanley, B Sakthivel, N Cvijanovich, R Lin, GL Allen, ... Physiological genomics 30 (2), 146-155, 2007 | 279 | 2007 |