Safety, activity, and immune correlates of anti–PD-1 antibody in cancer SL Topalian, FS Hodi, JR Brahmer, SN Gettinger, DC Smith, ... New England Journal of Medicine 366 (26), 2443-2454, 2012 | 13858 | 2012 |
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival TJ Curiel, G Coukos, L Zou, X Alvarez, P Cheng, P Mottram, ... Nature medicine 10 (9), 942-949, 2004 | 6285 | 2004 |
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion H Dong, SE Strome, DR Salomao, H Tamura, F Hirano, DB Flies, ... Nature medicine 8 (8), 793-800, 2002 | 6079 | 2002 |
Phase I study of single-agent anti–programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates JR Brahmer, CG Drake, I Wollner, JD Powderly, J Picus, WH Sharfman, ... Journal of clinical oncology 28 (19), 3167, 2010 | 3575 | 2010 |
Molecular mechanisms of T cell co-stimulation and co-inhibition L Chen, DB Flies Nature reviews immunology 13 (4), 227-242, 2013 | 3514 | 2013 |
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion H Dong, G Zhu, K Tamada, L Chen Nature medicine 5 (12), 1365-1369, 1999 | 2998 | 1999 |
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti–PD-1 therapy JM Taube, A Klein, JR Brahmer, H Xu, X Pan, JH Kim, L Chen, DM Pardoll, ... Clinical cancer research 20 (19), 5064-5074, 2014 | 2543 | 2014 |
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape JM Taube, RA Anders, GD Young, H Xu, R Sharma, TL McMiller, S Chen, ... Science translational medicine 4 (127), 127ra37-127ra37, 2012 | 2417 | 2012 |
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations W Zou, JD Wolchok, L Chen Science translational medicine 8 (328), 328rv4-328rv4, 2016 | 2243 | 2016 |
Inhibitory B7-family molecules in the tumour microenvironment W Zou, L Chen Nature Reviews Immunology 8 (6), 467-477, 2008 | 1991 | 2008 |
Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity L Chen Nature Reviews Immunology 4 (5), 336-347, 2004 | 1683 | 2004 |
Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity TJ Curiel, S Wei, H Dong, X Alvarez, P Cheng, P Mottram, R Krzysiek, ... Nature medicine 9 (5), 562-567, 2003 | 1547 | 2003 |
Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future L Chen, X Han The Journal of clinical investigation 125 (9), 3384-3391, 2015 | 1445 | 2015 |
Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4 L Chen, S Ashe, WA Brady, I Hellström, KE Hellström, JA Ledbetter, ... Cell 71 (7), 1093-1102, 1992 | 1434 | 1992 |
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity F Hirano, K Kaneko, H Tamura, H Dong, S Wang, M Ichikawa, C Rietz, ... Cancer research 65 (3), 1089-1096, 2005 | 1323 | 2005 |
B7-H3: a costimulatory molecule for T cell activation and IFN-γ production AI Chapoval, J Ni, JS Lau, RA Wilcox, DB Flies, D Liu, H Dong, GL Sica, ... Nature immunology 2 (3), 269-274, 2001 | 1255 | 2001 |
A paradigm shift in cancer immunotherapy: from enhancement to normalization MF Sanmamed, L Chen Cell 175 (2), 313-326, 2018 | 1241 | 2018 |
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors I Melero, WW Shuford, SA Newby, A Aruffo, JA Ledbetter, KE Hellström, ... Nature medicine 3 (6), 682-685, 1997 | 1188 | 1997 |
Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target RH Thompson, MD Gillett, JC Cheville, CM Lohse, H Dong, WS Webster, ... Proceedings of the National Academy of Sciences 101 (49), 17174-17179, 2004 | 1045 | 2004 |
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity GL Sica, IH Choi, G Zhu, K Tamada, SD Wang, H Tamura, AI Chapoval, ... Immunity 18 (6), 849-861, 2003 | 1034 | 2003 |