关注
Mehran Nikan
Mehran Nikan
Research Fellow, Ionis Pharmaceuticals
在 ionisph.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
R Rodriguez, KM Miller, JV Forment, CR Bradshaw, M Nikan, S Britton, ...
Nature chemical biology 8 (3), 301-310, 2012
7132012
A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro
EA Raiber, R Kranaster, E Lam, M Nikan, S Balasubramanian
Nucleic acids research 40 (4), 1499-1508, 2012
2252012
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
MR Hassler, AA Turanov, JF Alterman, RA Haraszti, AH Coles, MF Osborn, ...
Nucleic acids research 46 (5), 2185-2196, 2018
1582018
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
MF Osborn, AH Coles, A Biscans, RA Haraszti, L Roux, S Davis, S Ly, ...
Nucleic acids research 47 (3), 1070-1081, 2019
1172019
Docosahexaenoic acid conjugation enhances distribution and safety of siRNA upon local administration in mouse brain
M Nikan, MF Osborn, AH Coles, BMDC Godinho, LM Hall, RA Haraszti, ...
Molecular Therapy-Nucleic Acids 5, 2016
922016
Template-assembled synthetic G-quartets (TASQs)
M Nikan
University of British Columbia, 2008
742008
Overcoming the challenges of tissue delivery for oligonucleotide therapeutics
T Gökirmak, M Nikan, S Wiechmann, TP Prakash, M Tanowitz, PP Seth
Trends in pharmacological sciences 42 (7), 588-604, 2021
602021
Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs
MF Osborn, JF Alterman, M Nikan, H Cao, MC Didiot, MR Hassler, ...
Nucleic acids research 43 (18), 8664-8672, 2015
502015
An acetylene‐bridged 6, 8‐purine dimer as a fluorescent switch‐on probe for parallel G‐quadruplexes
M Nikan, M Di Antonio, K Abecassis, K McLuckie, S Balasubramanian
Angewandte Chemie International Edition 52 (5), 1428-1431, 2013
502013
Glucagon like peptide 1 receptor agonists for targeted delivery of antisense oligonucleotides to pancreatic beta cell
L Knerr, TP Prakash, R Lee, WJ Drury III, M Nikan, W Fu, E Pirie, LD Maria, ...
Journal of the American Chemical Society 143 (9), 3416-3429, 2021
472021
Pharmacokinetic profiling of conjugated therapeutic oligonucleotides: a high-throughput method based upon serial blood microsampling coupled to peptide nucleic acid …
BMDC Godinho, JW Gilbert, RA Haraszti, AH Coles, A Biscans, L Roux, ...
nucleic acid therapeutics 27 (6), 323-334, 2017
442017
Cation-complexation behavior of template-assembled synthetic G-quartets
M Nikan, JC Sherman
The Journal of Organic Chemistry 74 (15), 5211-5218, 2009
432009
Hydrophobicity of lipid-conjugated siRNAs predicts productive loading to small extracellular vesicles
A Biscans, RA Haraszti, D Echeverria, R Miller, MC Didiot, M Nikan, ...
Molecular Therapy 26 (6), 1520-1528, 2018
402018
Transvascular delivery of hydrophobically modified siRNAs: gene silencing in the rat brain upon disruption of the blood-brain barrier
BMDC Godinho, N Henninger, J Bouley, JF Alterman, RA Haraszti, ...
Molecular Therapy 26 (11), 2580-2591, 2018
382018
Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in …
M Nikan, MF Osborn, AH Coles, A Biscans, BMDC Godinho, RA Haraszti, ...
Bioconjugate chemistry 28 (6), 1758-1766, 2017
382017
Targeted delivery of antisense oligonucleotides using neurotensin peptides
M Nikan, M Tanowitz, CA Dwyer, M Jackson, HJ Gaus, EE Swayze, ...
Journal of Medicinal Chemistry 63 (15), 8471-8484, 2020
322020
Synthesis of a water-soluble triazole-linked cavitand–guanosine conjugate
M Nikan, GAL Bare, JC Sherman
Tetrahedron letters 52 (15), 1791-1793, 2011
202011
Bioactive conjugates for oligonucleotide delivery
A Khvorova, M Nikan, M Hassler, M Osborn, R Haraszti, A Coles, ...
US Patent 10,633,653, 2020
172020
Crystal Structure of a Template‐Assembled Synthetic G‐Quadruplex
M Nikan, BO Patrick, JC Sherman
ChemBioChem 13 (10), 1413-1415, 2012
162012
Targeted Delivery of Antisense Oligonucleotides Through Angiotensin Type 1 Receptor
C Kuo, M Nikan, ST Yeh, AE Chappell, M Tanowitz, PP Seth, TP Prakash, ...
nucleic acid therapeutics 32 (4), 300-311, 2022
52022
系统目前无法执行此操作,请稍后再试。
文章 1–20