Inhibition of diabetic nephropathy by a decoy peptide corresponding to the “handle” region for nonproteolytic activation of prorenin A Ichihara, M Hayashi, Y Kaneshiro, F Suzuki, T Nakagawa, Y Tada, ... The Journal of clinical investigation 114 (8), 1128-1135, 2004 | 566 | 2004 |
Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor–deficient mice A Ichihara, F Suzuki, T Nakagawa, Y Kaneshiro, T Takemitsu, M Sakoda, ... Journal of the American Society of Nephrology 17 (7), 1950-1961, 2006 | 348 | 2006 |
Slowly progressive, angiotensin II–independent glomerulosclerosis in human (pro) renin receptor–transgenic rats Y Kaneshiro, A Ichihara, M Sakoda, T Takemitsu, AHMN Nabi, MN Uddin, ... Journal of the American Society of Nephrology 18 (6), 1789-1795, 2007 | 309 | 2007 |
Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension A Ichihara, Y Kaneshiro, T Takemitsu, M Sakoda, F Suzuki, T Nakagawa, ... Hypertension 47 (5), 894-900, 2006 | 306 | 2006 |
Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression. K Nakayama, WS Kim, S Torii, M Hosaka, T Nakagawa, J Ikemizu, T Baba, ... Journal of Biological Chemistry 267 (9), 5897-5900, 1992 | 298 | 1992 |
Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells. K Hatsuzawa, M Hosaka, T Nakagawa, M Nagase, A Shoda, K Murakami, ... Journal of Biological Chemistry 265 (36), 22075-22078, 1990 | 278 | 1990 |
Human prorenin has “gate and handle” regions for its non-proteolytic activation F Suzuki, M Hayakawa, T Nakagawa, UM Nasir, A Ebihara, A Iwasawa, ... Journal of Biological Chemistry 278 (25), 22217-22222, 2003 | 243 | 2003 |
Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4 T Nakagawa, M Hosaka, S Torii, T Watanabe, K Murakami, K Nakayama The Journal of Biochemistry 113 (2), 132-135, 1993 | 238 | 1993 |
Urinary angiotensinogen as a marker of intrarenal angiotensin II activity associated with deterioration of renal function in patients with chronic kidney disease T Yamamoto, T Nakagawa, H Suzuki, N Ohashi, H Fukasawa, Y Fujigaki, ... Journal of the American Society of Nephrology 18 (5), 1558-1565, 2007 | 225 | 2007 |
Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system AHM Nabi, A Kageshima, MN Uddin, T Nakagawa, EY Park, F Suzuki International journal of molecular medicine 18 (3), 483-488, 2006 | 203 | 2006 |
Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats Y Kaneshiro, A Ichihara, T Takemitsu, M Sakoda, F Suzuki, T Nakagawa, ... Kidney international 70 (4), 641-646, 2006 | 181 | 2006 |
Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage A Ichihara, Y Kaneshiro, T Takemitsu, M Sakoda, T Nakagawa, ... Journal of the American Society of Nephrology 17 (9), 2495-2503, 2006 | 175 | 2006 |
Localization of furin to the trans-Golgi network and recycling from the cell surface involves Ser and Tyr residues within the cytoplasmic domain S Takahashi, T Nakagawa, T Banno, T Watanabe, K Murakami, ... Journal of Biological Chemistry 270 (47), 28397-28401, 1995 | 172 | 1995 |
Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease T Nakagawa, K Murakami, K Nakayama FEBS letters 327 (2), 165-171, 1993 | 160 | 1993 |
Consensus sequence for precursor processing at mono-arginyl sites. Evidence for the involvement of a Kex2-like endoprotease in precursor cleavages at both dibasic and mono … K Nakayama, T Watanabe, T Nakagawa, WS Kim, M Nagahama, ... Journal of biological chemistry 267 (23), 16335-16340, 1992 | 144 | 1992 |
Sequence requirements for precursor cleavage within the constitutive secretory pathway. T Watanabe, T Nakagawa, J Ikemizu, M Nagahama, K Murakami, ... Journal of Biological Chemistry 267 (12), 8270-8274, 1992 | 143 | 1992 |
A second mutant allele of furin in the processing-incompetent cell line, LoVo: evidence for involvement of the homo B domain in autocatalytic activation S Takahashi, T Nakagawa, K Kasai, T Banno, SJ Duguay, ... Journal of Biological Chemistry 270 (44), 26565-26569, 1995 | 126 | 1995 |
(Pro) Renin receptor–mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells M Sakoda, A Ichihara, Y Kaneshiro, T Takemitsu, Y Nakazato, AHM Nabi, ... Hypertension Research 30 (11), 1139-1146, 2007 | 119 | 2007 |
Site-1 protease is required for the generation of soluble (pro) renin receptor T Nakagawa, C Suzuki-Nakagawa, A Watanabe, E Asami, M Matsumoto, ... The journal of biochemistry 161 (4), 369-379, 2017 | 99 | 2017 |
Nine polymorphisms of angiotensinogen gene in the susceptibility to essential hypertension N Sato, T Katsuya, T Nakagawa, K Ishikawa, Y Fu, T Asai, M Fukuda, ... Life sciences 68 (3), 259-272, 2000 | 91 | 2000 |