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Frank Poelwijk
Frank Poelwijk
Generate Biomedicines LLC
在 generatebiomedicines.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Mutation effects predicted from sequence co-variation
TA Hopf, JB Ingraham, FJ Poelwijk, CPI Schärfe, M Springer, C Sander, ...
Nature biotechnology 35 (2), 128-135, 2017
6102017
Empirical fitness landscapes reveal accessible evolutionary paths
FJ Poelwijk, DJ Kiviet, DM Weinreich, SJ Tans
Nature 445 (7126), 383-386, 2007
6002007
The spatial architecture of protein function and adaptation
RN McLaughlin Jr, FJ Poelwijk, A Raman, WS Gosal, R Ranganathan
Nature 491 (7422), 138-142, 2012
5232012
Reciprocal sign epistasis is a necessary condition for multi-peaked fitness landscapes
FJ Poelwijk, S Tănase-Nicola, DJ Kiviet, SJ Tans
Journal of theoretical biology 272 (1), 141-144, 2011
2352011
Illuminating protein space with a programmable generative model
JB Ingraham, M Baranov, Z Costello, KW Barber, W Wang, A Ismail, ...
Nature, 1-9, 2023
1772023
Inferring protein 3D structure from deep mutation scans.
NJ Rollins, KP Brock, FJ Poelwijk, MA Stiffler, NP Gauthier, C Sander, ...
Nature Genetics 51 (7), 1170-1176, 2019
1522019
Learning the pattern of epistasis linking genotype and phenotype in a protein
FJ Poelwijk, M Socolich, R Ranganathan
Nature communications 10 (1), 1-11, 2019
1442019
LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function
SR Holmstrom, T Deering, GH Swift, FJ Poelwijk, DJ Mangelsdorf, ...
Genes & development 25 (16), 1674-1679, 2011
1372011
Tradeoffs and optimality in the evolution of gene regulation
FJ Poelwijk, MGJ de Vos, SJ Tans
Cell 146 (3), 462-470, 2011
1272011
The Context-Dependence of Mutations: A Linkage of Formalisms
FJ Poelwijk, V Krishna, R Ranganathan
PLoS Computational Biology 12 (6), e1004771, 2016
1092016
Dynamics of a random laser above threshold
G van Soest, FJ Poelwijk, R Sprik, A Lagendijk
Physical Review Letters 86 (8), 1522, 2001
1042001
Photon correlation spectroscopy: X rays versus visible light
DO Riese, WL Vos, GH Wegdam, FJ Poelwijk, DL Abernathy, G Grübel
Physical Review E 61 (2), 1676, 2000
682000
Environmental dependence of genetic constraint
MGJ de Vos, FJ Poelwijk, N Battich, JDT Ndika, SJ Tans
PLoS Genet 9 (6), e1003580, 2013
582013
Evolutionary potential of a duplicated repressor-operator pair: simulating pathways using mutation data
FJ Poelwijk, DJ Kiviet, SJ Tans
PLoS Comput Biol 2 (5), e58, 2006
552006
Mutant Cas9 proteins
A Chavez, F Poelwijk, GM Church
US Patent 9,074,199, 2015
472015
Mutant Cas9 proteins
A Chavez, F Poelwijk, GM Church
US Patent 10,100,291, 2018
402018
Protein structure from experimental evolution
MA Stiffler, FJ Poelwijk, KP Brock, RR Stein, A Riesselman, J Teyra, ...
Cell Systems 10 (1), 15-24. e5, 2020
392020
Quantification of the effect of mutations using a global probability model of natural sequence variation
TA Hopf, JB Ingraham, FJ Poelwijk, M Springer, C Sander, DS Marks
arXiv preprint arXiv:1510.04612, 2015
382015
Speckle experiments in random lasers
G Van Soest, FJ Poelwijk, A Lagendijk
Physical Review E 65 (4), 046603, 2002
352002
Optimality and evolution of transcriptionally regulated gene expression
FJ Poelwijk, PD Heyning, MGJ de Vos, DJ Kiviet, SJ Tans
BMC systems biology 5 (1), 1-12, 2011
312011
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