Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling B Liu, W Chen, BD Evavold, C Zhu Cell 157 (2), 357-368, 2014 | 581 | 2014 |
T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex JJ Adams, S Narayanan, B Liu, ME Birnbaum, AC Kruse, NA Bowerman, ... Immunity 35 (5), 681-693, 2011 | 292 | 2011 |
Forcing switch from short-to intermediate-and long-lived states of the αA domain generates LFA-1/ICAM-1 catch bonds W Chen, J Lou, C Zhu Journal of Biological Chemistry 285 (46), 35967-35978, 2010 | 210 | 2010 |
Flow-enhanced adhesion regulated by a selectin interdomain hinge J Lou, T Yago, AG Klopocki, P Mehta, W Chen, VI Zarnitsyna, NV Bovin, ... The Journal of cell biology 174 (7), 1107-1117, 2006 | 185 | 2006 |
Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells W Chen, J Lou, EA Evans, C Zhu Journal of Cell Biology 199 (3), 497-512, 2012 | 173 | 2012 |
Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA H Chen, Y Cui, X Han, W Hu, M Sun, Y Zhang, PH Wang, G Song, ... Cell research 30 (12), 1143-1145, 2020 | 150 | 2020 |
Mechanosensing through immunoreceptors C Zhu, W Chen, J Lou, W Rittase, K Li Nature immunology 20 (10), 1269-1278, 2019 | 146 | 2019 |
Monitoring receptor-ligand interactions between surfaces by thermal fluctuations W Chen, EA Evans, RP McEver, C Zhu Biophysical journal 94 (2), 694-701, 2008 | 135 | 2008 |
Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition P Wu, T Zhang, B Liu, P Fei, L Cui, R Qin, H Zhu, D Yao, RJ Martinez, ... Molecular cell 73 (5), 1015-1027, 2019 | 111 | 2019 |
Mechanical regulation of T‐cell functions W Chen, C Zhu Immunological reviews 256 (1), 160-176, 2013 | 111 | 2013 |
Measuring receptor–ligand binding kinetics on cell surfaces: from adhesion frequency to thermal fluctuation methods W Chen, VI Zarnitsyna, KK Sarangapani, J Huang, C Zhu Cellular and molecular bioengineering 1, 276-288, 2008 | 102 | 2008 |
Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis YI Choi, JS Duke-Cohan, W Chen, B Liu, J Rossy, T Tabarin, L Ju, J Gui, ... Proceedings of the National Academy of Sciences 111 (1), 379-384, 2014 | 73 | 2014 |
Molecular force spectroscopy on cells B Liu, W Chen, C Zhu Annual review of physical chemistry 66 (1), 427-451, 2015 | 71 | 2015 |
Triphasic force dependence of E-selectin/ligand dissociation governs cell rolling under flow AM Wayman, W Chen, RP McEver, C Zhu Biophysical journal 99 (4), 1166-1174, 2010 | 67 | 2010 |
Regulation of catch bonds by rate of force application KK Sarangapani, J Qian, W Chen, VI Zarnitsyna, P Mehta, T Yago, ... Journal of Biological Chemistry 286 (37), 32749-32761, 2011 | 63 | 2011 |
Fluorescence biomembrane force probe: concurrent quantitation of receptor-ligand kinetics and binding-induced intracellular signaling on a single cell Y Chen, B Liu, L Ju, J Hong, Q Ji, W Chen, C Zhu JoVE (Journal of Visualized Experiments), e52975, 2015 | 59 | 2015 |
Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase S Shaheen, Z Wan, Z Li, A Chau, X Li, S Zhang, Y Liu, J Yi, Y Zeng, ... Elife 6, e23060, 2017 | 54 | 2017 |
The cellular environment regulates in situ kinetics of T‐cell receptor interaction with peptide major histocompatibility complex B Liu, W Chen, K Natarajan, Z Li, DH Margulies, C Zhu European journal of immunology 45 (7), 2099-2110, 2015 | 50 | 2015 |
Mechanical activation of spike fosters SARS-CoV-2 viral infection W Hu, Y Zhang, P Fei, T Zhang, D Yao, Y Gao, J Liu, H Chen, Q Lu, ... Cell Research 31 (10), 1047-1060, 2021 | 35 | 2021 |
NKG2D discriminates diverse ligands through selectively mechano‐regulated ligand conformational changes J Fan, J Shi, Y Zhang, J Liu, C An, H Zhu, P Wu, W Hu, R Qin, D Yao, ... The EMBO journal 41 (2), e107739, 2022 | 32 | 2022 |