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Alex L. Wilkinson
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The role of sinusoidal endothelial cells in the axis of inflammation and cancer within the liver
AL Wilkinson, M Qurashi, S Shetty
Frontiers in physiology 11, 990, 2020
1082020
Hepatocytes delete regulatory T cells by enclysis, a CD4+ T cell engulfment process
SP Davies, GM Reynolds, AL Wilkinson, X Li, R Rose, M Leekha, YS Liu, ...
Cell reports 29 (6), 1610-1620. e4, 2019
432019
Cell-in-cell structures in the liver: a tale of four E’s
SP Davies, LV Terry, AL Wilkinson, Z Stamataki
Frontiers in immunology 11, 650, 2020
332020
Pharmacological characterisation of a tool αvβ1 integrin small molecule RGD-mimetic inhibitor
AL Wilkinson, JW Barrett, RJ Slack
European journal of pharmacology 842, 239-247, 2019
182019
Scavenger receptors: novel roles in the pathogenesis of liver inflammation and cancer
DA Patten, AL Wilkinson, A O'Keeffe, S Shetty
Seminars in Liver Disease 42 (01), 061-076, 2022
122022
Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen
CU Onyishi, GE Desanti, AL Wilkinson, S Lara-Reyna, EM Frickel, G Fejer, ...
Nature Communications 14 (1), 4895, 2023
112023
Prognostic value and potential immunoregulatory role of SCARF1 in hepatocellular carcinoma
DA Patten, AL Wilkinson, JM O'rourke, S Shetty
Frontiers in Oncology 10, 565950, 2020
112020
Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease
AL Wilkinson, AE John, JW Barrett, E Gower, VS Morrison, Y Man, KT Pun, ...
European Journal of Pharmacology 913, 174618, 2021
62021
The role of sinusoidal endothelial cells in the axis of inflammation and cancer within the liver. Front Physiol 11: 990
AL Wilkinson, M Qurashi, S Shetty
52020
A three-dimensional spheroid model to investigate the tumor-stromal interaction in hepatocellular carcinoma
MYW Zaki, S Shetty, AL Wilkinson, DA Patten, F Oakley, H Reeves
JoVE (Journal of Visualized Experiments), e62868, 2021
42021
Downregulation of the αvβ6 Integrin via RGD Engagement Is Affinity and Time Dependent
JA Roper, AL Wilkinson, E Gower, RJ Slack
Journal of Pharmacology and Experimental Therapeutics 376 (2), 273-280, 2021
42021
P109 high affinity engagement of the αvβ6 integrin induces degradation: a novel mechanism for sustained inhibition of pro-fibrotic TGFβ activation
E Gower, A Wilkinson, V Morrison, C Nanthakumar, R Slack
QJ Med 109 (suppl 1), S59-S5S, 2016
42016
The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration
AL Wilkinson, S Hulme, JI Kennedy, ER Mann, P Horn, EL Shepherd, ...
Iscience 26 (10), 2023
12023
Reciprocal regulation of TLR4, TLR3 and Macrophage Scavenger Receptor 1 regulates nonopsonic phagocytosis of the fungal pathogen Cryptococcus neoformans
CU Onyishi, GE Desanti, AL Wilkinson, G Fejer, OD Christophe, ...
bioRxiv, 2023.01. 30.525903, 2023
12023
P176 TSPAN6: a novel player in the microenvironment of primary liver cancers
OO Bolimowska, DA Patten, S Shetty, F Berditchevski, JM O’Rourke, ...
Gut 70 (Suppl 1), A134-A135, 2021
12021
FRI-487 Immunosuppressive CD73 is upregulated on tumour endothelium and may limit effective immune infiltrate in hepatocellular carcinoma
R Faulkes, D Patten, A Wilkinson, J O'Rourke, A O'Keeffe, J Kennedy, ...
Journal of Hepatology 80, S423-S424, 2024
2024
Organ-on-a-chip for studying immune cell adhesion to liver sinusoidal endothelial cells: the potential for testing immunotherapies and cell therapy trafficking
JI Kennedy, SP Davies, PW Hewett, AL Wilkinson, YH Oo, WY Lu, ...
Frontiers in cell and developmental biology 12, 1359451, 2024
2024
Organ-on-a-chip for studying immune cell adhesion to liver sinusoidal endothelial cells
JI Kennedy, SP Davies, PW Hewett, AL Wilkinson, YH Oo, WY Lu, ...
2024
Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen.
GE Desanti, G Fejer, OD Christophe, CU Onyishi, AL Wilkinson, ...
2023
Investigating the role of MR and PLVAP in hepatic leukocyte recruitment during chronic liver inflammation
AL Wilkinson
University of Birmingham, 2023
2023
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