Insights from molecular dynamics simulations for computational protein design MC Childers, V Daggett Molecular systems design & engineering 2 (1), 9-33, 2017 | 226 | 2017 |
α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease D Shea, CC Hsu, TM Bi, N Paranjapye, MC Childers, J Cochran, ... Proceedings of the National Academy of Sciences 116 (18), 8895-8900, 2019 | 156 | 2019 |
Validating molecular dynamics simulations against experimental observables in light of underlying conformational ensembles MC Childers, V Daggett The Journal of Physical Chemistry B 122 (26), 6673-6689, 2018 | 93 | 2018 |
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin JD Powers, CC Yuan, KJ McCabe, JD Murray, MC Childers, GV Flint, ... Proceedings of the National Academy of Sciences 116 (23), 11502-11507, 2019 | 41 | 2019 |
Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force W Ma, TS McMillen, MC Childers, H Gong, M Regnier, T Irving Proceedings of the National Academy of Sciences 120 (5), e2207615120, 2023 | 27 | 2023 |
Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2′‐deoxy‐ATP W Ma, M Childers, J Murray, F Moussavi‐Harami, H Gong, R Weiss, ... The Journal of physiology 598 (22), 5165-5182, 2020 | 27 | 2020 |
The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein design MC Childers, CL Towse, V Daggett Protein Engineering, Design and Selection 29 (7), 271-280, 2016 | 26 | 2016 |
Edge strand dissociation and conformational changes in transthyretin under amyloidogenic conditions MC Childers, V Daggett Biophysical Journal 119 (10), 1995-2009, 2020 | 15 | 2020 |
Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts M Landim-Vieira, MC Childers, AL Wacker, MR Garcia, H He, R Singh, ... Elife 11, e74919, 2022 | 14 | 2022 |
Drivers of α-sheet formation in transthyretin under amyloidogenic conditions MC Childers, V Daggett Biochemistry 58 (44), 4408-4423, 2019 | 14 | 2019 |
Modulation of post-powerstroke dynamics in myosin II by 2′-deoxy-ADP MC Childers, M Geeves, V Daggett, M Regnier Archives of biochemistry and biophysics 699, 108733, 2021 | 11 | 2021 |
Molecular dynamics-derived rotamer libraries for d-amino acids within homochiral and heterochiral polypeptides MC Childers, CL Towse, V Daggett Protein Engineering, Design and Selection 31 (6), 191-204, 2018 | 9 | 2018 |
Conserved patterns and interactions in the unfolding transition state across SH3 domain structural homologues C Demakis, MC Childers, V Daggett Protein Science 30 (2), 391-407, 2021 | 6 | 2021 |
Molecular dynamics methods for antibody design MC Childers, V Daggett Computer-Aided Antibody Design, 109-124, 2022 | 5 | 2022 |
Variants in ACTC1 underlie distal arthrogryposis accompanied by congenital heart defects JX Chong, MC Childers, CT Marvin, AJ Marcello, H Gonorazky, ... Human Genetics and Genomics Advances 4 (3), 2023 | 4 | 2023 |
Insights from molecular dynamics simulations for computational protein design. Molecular Systems Design & Engineering, 2 (1), 9–33 MC Childers, V Daggett | 4 | 2017 |
Atomistic simulations of sarcomere proteins MC Childers, M Regnier Familial Cardiomyopathies: Methods and Protocols, 27-41, 2023 | 2 | 2023 |
Conformational sampling of CMT-2D associated GlyRS mutations MC Childers, M Regnier, M Bothwell, AST Smith Brain multiphysics 3, 100054, 2022 | 2 | 2022 |
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin MJ Rynkiewicz, MC Childers, OE Karpicheva, M Regnier, MA Geeves, ... Journal of General Physiology 156 (5), e202413538, 2024 | 1 | 2024 |
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin W Lehman, MC Childers, M Regnier, MA Geeves, MJ Rynkiewicz Biophysical Journal 123 (3), 16a-17a, 2024 | 1 | 2024 |