Impact of deleterious passenger mutations on cancer progression CD McFarland, KS Korolev, GV Kryukov, SR Sunyaev, LA Mirny Proceedings of the National Academy of Sciences 110 (8), 2910-2915, 2013 | 343 | 2013 |
Massively parallel digital transcriptional profiling of single cells. Nat. Commun. 8, 14049 GXY Zheng, JM Terry, P Belgrader, P Ryvkin, ZW Bent, R Wilson, ... | 239 | 2017 |
Tug-of-war between driver and passenger mutations in cancer and other adaptive processes CD McFarland, LA Mirny, KS Korolev Proceedings of the National Academy of Sciences 111 (42), 15138-15143, 2014 | 170 | 2014 |
A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo ZN Rogers, CD McFarland, IP Winters, S Naranjo, CH Chuang, D Petrov, ... Nature methods 14 (7), 737-742, 2017 | 131 | 2017 |
The damaging effect of passenger mutations on cancer progression CD McFarland, JA Yaglom, JW Wojtkowiak, JG Scott, DL Morse, ... Cancer research 77 (18), 4763-4772, 2017 | 128 | 2017 |
Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice ZN Rogers, CD McFarland, IP Winters, JA Seoane, JJ Brady, S Yoon, ... Nature genetics 50 (4), 483-486, 2018 | 121 | 2018 |
Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity IP Winters, SH Chiou, NK Paulk, CD McFarland, PV Lalgudi, RK Ma, ... Nature communications 8 (1), 2053, 2017 | 105 | 2017 |
Massively parallel digital transcriptional profiling of single cells. Nat Commun. 2017; 8: 14049 GXY Zheng, JM Terry, P Belgrader, P Ryvkin, ZW Bent, R Wilson, ... | 82 | 2019 |
An in vivo multiplexed small-molecule screening platform BM Grüner, CJ Schulze, D Yang, D Ogasawara, MM Dix, ZN Rogers, ... Nature methods 13 (10), 883-889, 2016 | 68 | 2016 |
A functional taxonomy of tumor suppression in oncogenic KRAS–driven lung cancer H Cai, SK Chew, C Li, MK Tsai, L Andrejka, CW Murray, NW Hughes, ... Cancer discovery 11 (7), 1754-1773, 2021 | 40 | 2021 |
Most cancers carry a substantial deleterious load due to Hill-Robertson interference S Tilk, S Tkachenko, C Curtis, DA Petrov, CD McFarland elife 11, e67790, 2022 | 28 | 2022 |
Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer JA Yaglom, C McFarland, L Mirny, MY Sherman Oncotarget 5 (18), 8367, 2014 | 23 | 2014 |
Quantitative In Vivo Analyses Reveal a Complex Pharmacogenomic Landscape in Lung Adenocarcinoma C Li, WY Lin, H Rizvi, H Cai, CD McFarland, ZN Rogers, M Yousefi, ... Cancer research 81 (17), 4570-4580, 2021 | 18 | 2021 |
Seasonal epidemiology of gastrointestinal nematodes of cattle in the northern continental climate zone of western Canada as revealed by internal transcribed spacer-2 ribosomal … T Wang, EM Redman, A Morosetti, R Chen, S Kulle, N Morden, ... Parasites & Vectors 14, 1-13, 2021 | 15 | 2021 |
An improved model for the population dynamics of cattle gastrointestinal nematodes on pasture: parameterisation and field validation for Ostertagia ostertagi and Cooperia … T Wang, HR Vineer, E Redman, A Morosetti, R Chen, C McFarland, ... Veterinary parasitology 310, 109777, 2022 | 11 | 2022 |
Tracking gastrointestinal nematode risk on cattle farms through pasture contamination mapping C McFarland, HR Vineer, L Chesney, N Henry, C Brown, P Airs, ... International Journal for Parasitology 52 (10), 691-703, 2022 | 11 | 2022 |
A modified ziggurat algorithm for generating exponentially and normally distributed pseudorandom numbers CD McFarland Journal of Statistical Computation and Simulation, 1-14, 2015 | 10 | 2015 |
Novel epidemiological model of gastrointestinal nematode infection to assess grazing cattle resilience by integrating host growth, parasite, grass and environmental dynamics JAN Filipe, I Kyriazakis, C McFarland, ER Morgan International Journal for Parasitology 53 (3), 133-155, 2023 | 9 | 2023 |
The role of deleterious passengers in cancer CD McFarland Harvard University, 2014 | 7 | 2014 |
Passenger DNA alterations reduce cancer fitness in cell culture and mouse models CD McFarland, JA Yaglom, JW Wojtkowiak, JG Scott, DL Morse, ... bioRxiv, 026302, 2015 | 6 | 2015 |