Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease KM De Lange, L Moutsianas, JC Lee, CA Lamb, Y Luo, NA Kennedy, ... Nature genetics 49 (2), 256-261, 2017 | 1244 | 2017 |
Multiple common variants for celiac disease influencing immune gene expression PCA Dubois, G Trynka, L Franke, KA Hunt, J Romanos, A Curtotti, ... Nature genetics 42 (4), 295-302, 2010 | 1221 | 2010 |
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease G Trynka, KA Hunt, NA Bockett, J Romanos, V Mistry, A Szperl, SF Bakker, ... Nature genetics 43 (12), 1193-1201, 2011 | 958 | 2011 |
Shared and distinct genetic variants in type 1 diabetes and celiac disease DJ Smyth, V Plagnol, NM Walker, JD Cooper, K Downes, JHM Yang, ... New England Journal of Medicine 359 (26), 2767-2777, 2008 | 927 | 2008 |
Newly identified genetic risk variants for celiac disease related to the immune response KA Hunt, A Zhernakova, G Turner, GAR Heap, L Franke, M Bruinenberg, ... Nature genetics 40 (4), 395-402, 2008 | 842 | 2008 |
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study NA Kennedy, GA Heap, HD Green, B Hamilton, C Bewshea, GJ Walker, ... The lancet Gastroenterology & hepatology 4 (5), 341-353, 2019 | 583 | 2019 |
The pattern and outcome of acute severe colitis LC Dinesen, AJ Walsh, MN Protic, G Heap, F Cummings, BF Warren, ... Journal of Crohn's and Colitis 4 (4), 431-437, 2010 | 389 | 2010 |
HLA-DQA1* 05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn’s disease A Sazonovs, NA Kennedy, L Moutsianas, GA Heap, DL Rice, M Reppell, ... Gastroenterology 158 (1), 189-199, 2020 | 314 | 2020 |
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-κB signalling G Trynka, A Zhernakova, J Romanos, L Franke, KA Hunt, G Turner, ... Gut 58 (8), 1078-1083, 2009 | 243 | 2009 |
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing GA Heap, JHM Yang, K Downes, BC Healy, KA Hunt, N Bockett, L Franke, ... Human molecular genetics 19 (1), 122-134, 2010 | 223 | 2010 |
HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants GA Heap, MN Weedon, CM Bewshea, A Singh, M Chen, JB Satchwell, ... Nature genetics 46 (10), 1131-1134, 2014 | 212 | 2014 |
Association of genetic variants in NUDT15 with thiopurine-induced myelosuppression in patients with inflammatory bowel disease GJ Walker, JW Harrison, GA Heap, MD Voskuil, V Andersen, ... Jama 321 (8), 773-785, 2019 | 140 | 2019 |
Exclusive enteral nutrition provides an effective bridge to safer interval elective surgery for adults with Crohn's disease N Heerasing, B Thompson, P Hendy, GA Heap, G Walker, R Bethune, ... Alimentary pharmacology & therapeutics 45 (5), 660-669, 2017 | 127 | 2017 |
Complex nature of SNP genotype effects on gene expression in primary human leucocytes GA Heap, G Trynka, RC Jansen, M Bruinenberg, MA Swertz, LC Dinesen, ... BMC medical genomics 2, 1-13, 2009 | 117 | 2009 |
Clinical features and HLA association of 5-aminosalicylate (5-ASA)-induced nephrotoxicity in inflammatory bowel disease GA Heap, K So, M Weedon, N Edney, C Bewshea, A Singh, V Annese, ... Journal of Crohn's and Colitis 10 (2), 149-158, 2016 | 114 | 2016 |
Genetics and pathogenesis of coeliac disease GA Heap, DA van Heel Seminars in immunology 21 (6), 346-354, 2009 | 113 | 2009 |
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population MA Rivas, BE Avila, J Koskela, H Huang, C Stevens, M Pirinen, ... PLoS genetics 14 (5), e1007329, 2018 | 95 | 2018 |
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility A Sazonovs, CR Stevens, GR Venkataraman, K Yuan, B Avila, MT Abreu, ... Nature genetics 54 (9), 1275-1283, 2022 | 87 | 2022 |
The genetics of chronic inflammatory diseases GA Heap, DA van Heel Human molecular genetics 18 (R1), R101-R106, 2009 | 77 | 2009 |
A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis MA Rivas, D Graham, P Sulem, C Stevens, AN Desch, P Goyette, ... Nature communications 7 (1), 12342, 2016 | 61 | 2016 |