| ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation AK Walker, KY Soo, V Sundaramoorthy, S Parakh, Y Ma, MA Farg, ... PloS one 8 (11), e81170, 2013 | 206 | 2013 |
| The unfolded protein response and the role of protein disulfide isomerase in neurodegeneration ER Perri, CJ Thomas, S Parakh, DM Spencer, JD Atkin Frontiers in cell and developmental biology 3, 80, 2016 | 191 | 2016 |
| Novel roles for protein disulphide isomerase in disease states: a double edged sword? S Parakh, JD Atkin Frontiers in cell and developmental biology 3, 30, 2015 | 154 | 2015 |
| Rab1-dependent ER–Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS KY Soo, M Halloran, V Sundaramoorthy, S Parakh, RP Toth, KA Southam, ... Acta neuropathologica 130, 679-697, 2015 | 137 | 2015 |
| Protein folding alterations in amyotrophic lateral sclerosis S Parakh, JD Atkin Brain research 1648, 633-649, 2016 | 126 | 2016 |
| Redox regulation in amyotrophic lateral sclerosis S Parakh, DM Spencer, MA Halloran, KY Soo, JD Atkin Oxidative medicine and cellular longevity 2013 (1), 408681, 2013 | 104 | 2013 |
| Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations A Konopka, DR Whelan, MS Jamali, E Perri, H Shahheydari, RP Toth, ... Molecular neurodegeneration 15, 1-28, 2020 | 75 | 2020 |
| The role of s‐nitrosylation and s‐glutathionylation of protein disulphide isomerase in protein misfolding and neurodegeneration M Halloran, S Parakh, JD Atkin International journal of cell biology 2013 (1), 797914, 2013 | 70 | 2013 |
| Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases S Shadfar, S Parakh, MS Jamali, JD Atkin Translational Neurodegeneration 12 (1), 18, 2023 | 50 | 2023 |
| Amyotrophic lateral sclerosis-linked UBQLN2 mutants inhibit endoplasmic reticulum to Golgi transport, leading to Golgi fragmentation and ER stress M Halloran, AMG Ragagnin, M Vidal, S Parakh, S Yang, B Heng, N Grima, ... Cellular and Molecular Life Sciences 77, 3859-3873, 2020 | 37 | 2020 |
| ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis S Parakh, CJ Jagaraj, M Vidal, AMG Ragagnin, ER Perri, A Konopka, ... Human Molecular Genetics 27 (8), 1311-1331, 2018 | 32 | 2018 |
| Emerging evidence highlighting the importance of redox dysregulation in the pathogenesis of amyotrophic lateral sclerosis (ALS) CJ Jagaraj, S Parakh, JD Atkin Frontiers in cellular neuroscience 14, 581950, 2021 | 28 | 2021 |
| The redox activity of protein disulfide isomerase inhibits ALS phenotypes in cellular and zebrafish models S Parakh, S Shadfar, ER Perri, AMG Ragagnin, CV Piattoni, MB Fogolín, ... Iscience 23 (5), 2020 | 25 | 2020 |
| Protein disulphide isomerases: emerging roles of PDI and ERp57 in the nervous system and as therapeutic targets for ALS E Perri, S Parakh, J Atkin Expert opinion on therapeutic targets 21 (1), 37-49, 2017 | 25 | 2017 |
| Rab-dependent cellular trafficking and amyotrophic lateral sclerosis S Parakh, ER Perri, CJ Jagaraj, AMG Ragagnin, JD Atkin Critical reviews in biochemistry and molecular biology 53 (6), 623-651, 2018 | 20 | 2018 |
| The Mitochondrial-associated ER membrane (MAM) compartment and its dysregulation in Amyotrophic Lateral Sclerosis (ALS) S Parakh, JD Atkin Seminars in Cell & Developmental Biology 112, 105-113, 2021 | 19 | 2021 |
| Protein disulphide isomerase (PDI) is protective against amyotrophic lateral sclerosis (ALS)-related mutant Fused in Sarcoma (FUS) in in vitro models S Parakh, ER Perri, M Vidal, J Sultana, S Shadfar, P Mehta, A Konopka, ... Scientific Reports 11 (1), 17557, 2021 | 11 | 2021 |
| The cysteine (Cys) residues Cys-6 and Cys-111 in mutant superoxide dismutase 1 (SOD1) A4V are required for induction of endoplasmic reticulum stress in amyotrophic lateral … ER Perri, S Parakh, M Vidal, P Mehta, Y Ma, AK Walker, JD Atkin Journal of Molecular Neuroscience 70, 1357-1368, 2020 | 8 | 2020 |
| Protein disulphide isomerase is associated with mutant SOD1 in canine degenerative myelopathy RC Chang, S Parakh, JR Coates, S Long, JD Atkin Neuroreport 30 (1), 8-13, 2019 | 8 | 2019 |
| Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis EC Browne, S Parakh, LF Duncan, SJ Langford, JD Atkin, BM Abbott Bioorganic & Medicinal Chemistry 24 (7), 1520-1527, 2016 | 5 | 2016 |
