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Kevin Dooley
Kevin Dooley
Alnylam
在 alnylam.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties
K Dooley, RE McConnell, K Xu, ND Lewis, S Haupt, MR Youniss, S Martin, ...
Molecular Therapy 29 (5), 1729-1743, 2021
2072021
Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity
S Kamerkar, C Leng, O Burenkova, SC Jang, C McCoy, K Zhang, ...
Science Advances 8 (7), eabj7002, 2022
1462022
Replacing antibodies: engineering new binding proteins
S Banta, K Dooley, O Shur
Annual review of biomedical engineering 15 (1), 93-113, 2013
1342013
ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
SC Jang, KD Economides, RJ Moniz, CL Sia, N Lewis, C McCoy, T Zi, ...
Communications biology 4 (1), 497, 2021
1072021
Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice
J Devalliere, K Dooley, Y Hu, SS Kelangi, BE Uygun, ML Yarmush
Biomaterials 141, 149-160, 2017
962017
Improving functional re-endothelialization of acellular liver scaffold using REDV cell-binding domain
J Devalliere, Y Chen, K Dooley, ML Yarmush, BE Uygun
Acta biomaterialia 78, 151-164, 2018
752018
Exosome surface display of IL12 results in tumor-retained pharmacology with superior potency and limited systemic exposure compared with recombinant IL12
ND Lewis, CL Sia, K Kirwin, S Haupt, G Mahimkar, T Zi, K Xu, K Dooley, ...
Molecular cancer therapeutics 20 (3), 523-534, 2021
732021
Rapid Development of New Protein Biosensors Utilizing Peptides Obtained via Phage Display
J Wu, JP Park, K Dooley, DM Cropek, AC West, S Banta
PloS one 6 (10), e24948, 2011
702011
A dual enzyme electrochemical assay for the detection of organophosphorus compounds using organophosphorus hydrolase and horseradish peroxidase
A Sahin, K Dooley, DM Cropek, AC West, S Banta
Sensors and Actuators B: Chemical, 2011
692011
Engineering of an Environmentally Responsive Beta Roll Peptide for Use As a Calcium-Dependent Cross-Linking Domain for Peptide Hydrogel Formation
K Dooley, YH Kim, HD Lu, R Tu, S Banta
Biomacromolecules 13 (6), 1758-1764, 2012
602012
A designed, phase changing RTX-based peptide for efficient bioseparations
O Shur, K Dooley, M Blenner, M Baltimore, S Banta
BioTechniques 54 (4), 197-206, 2013
332013
Improving the performance of methanol biofuel cells utilizing an enzyme cascade bioanode with DNA-bridged substrate channeling
L Xia, K Van Nguyen, Y Holade, H Han, K Dooley, P Atanassov, S Banta, ...
ACS Energy Letters 2 (6), 1435-1438, 2017
292017
Doubling the cross-linking interface of a rationally designed beta roll peptide for calcium-dependent proteinaceous hydrogel formation
K Dooley, B Bulutoglu, S Banta
Biomacromolecules 15 (10), 3617-3624, 2014
282014
In vivo tracking of [89Zr] Zr-labeled engineered extracellular vesicles by PET reveals organ-specific biodistribution based upon the route of administration
S Patel, KF Schmidt, M Farhoud, T Zi, SC Jang, K Dooley, D Kentala, ...
Nuclear medicine and biology 112, 20-30, 2022
232022
exoSTING: An engineered exosome therapeutic that selectively delivers STING agonist to the tumor resident antigen-presenting cells resulting in improved tumor antigen-specific …
SC Jang, RJ Moniz, CL Sia, RA Harrison, D Houde, N Ross, K Xu, ...
Cancer Research 79 (13_Supplement), 944-944, 2019
152019
Catch and release: engineered Allosterically regulated β-roll peptides enable on/off biomolecular recognition
B Bulutoglu, K Dooley, G Szilvay, M Blenner, S Banta
ACS Synthetic Biology 6 (9), 1732-1741, 2017
152017
Preparation of therapeutic exosomes using membrane proteins
KP Dooley, RA Harrison, RE McConnell, K Xu, DJ Houde, N Ross, ...
US Patent 10,561,740, 2020
112020
Functionalized biopolymer particles enhance performance of a tissue-protective peptide under proteolytic and thermal stress
K Dooley, J Devalliere, BE Uygun, ML Yarmush
Biomacromolecules 17 (6), 2073-2079, 2016
72016
Compositions of engineered exosomes and methods of loading luminal exosomes pay-loads
RE McConnell, KP Dooley, RA Harrison, K Xu, DJ Houde, S Haupt, ...
US Patent App. 16/765,116, 2020
32020
703 Engineered exosomes with altered cellular tropism achieve targeted STING agonist delivery and single-agent tumor control in vivo
M Kauke, N Ross, D Burzyn, S Martin, K Xu, N Lewis, C Leng, SC Jang, ...
Journal for ImmunoTherapy of Cancer 8 (Suppl 3), 2020
32020
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