Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations A Singanayagam, N Glanville, JL Girkin, YM Ching, A Marcellini, ... Nature communications 9 (1), 2229, 2018 | 184 | 2018 |
Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia L Hatchwell, A Collison, J Girkin, K Parsons, J Li, J Zhang, S Phipps, ... Thorax 70 (9), 854-861, 2015 | 109 | 2015 |
Antiviral immunity is impaired in COPD patients with frequent exacerbations A Singanayagam, SL Loo, M Calderazzo, LJ Finney, MB Trujillo Torralbo, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 317 (6 …, 2019 | 64 | 2019 |
CCL7 and IRF-7 mediate hallmark inflammatory and IFN responses following rhinovirus 1B infection J Girkin, L Hatchwell, P Foster, SL Johnston, N Bartlett, A Collison, ... The Journal of Immunology 194 (10), 4924-4930, 2015 | 46 | 2015 |
A critical role for the CXCL3/CXCL5/CXCR2 neutrophilic chemotactic axis in the regulation of type 2 responses in a model of rhinoviral-induced asthma exacerbation LA Sokulsky, K Garcia-Netto, TH Nguyen, JLN Girkin, A Collison, J Mattes, ... The Journal of Immunology 205 (9), 2468-2478, 2020 | 42 | 2020 |
Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A L Hatchwell, J Girkin, MD Dun, M Morten, N Verrills, HD Toop, JC Morris, ... Journal of allergy and clinical immunology 133 (6), 1720-1727, 2014 | 42 | 2014 |
TLR2-mediated innate immune priming boosts lung anti-viral immunity J Girkin, SL Loo, C Esneau, S Maltby, F Mercuri, B Chua, AT Reid, ... European Respiratory Journal 58 (1), 2021 | 24 | 2021 |
TRAIL signaling is proinflammatory and proviral in a murine model of rhinovirus 1B infection JL Girkin, LM Hatchwell, AM Collison, MR Starkey, PM Hansbro, H Yagita, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 312 (1 …, 2017 | 23 | 2017 |
TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs G Deliyannis, CY Wong, HA McQuilten, A Bachem, M Clarke, X Jia, ... JCI insight 6 (5), 2021 | 22 | 2021 |
Toll-like receptor-agonist-based therapies for respiratory viral diseases: thinking outside the cell JLN Girkin, S Maltby, NW Bartlett European Respiratory Review 31 (164), 2022 | 16 | 2022 |
IL-25 blockade augments antiviral immunity during respiratory virus infection TC Williams, SL Loo, KS Nichol, AT Reid, PC Veerati, C Esneau, ... Communications Biology 5 (1), 415, 2022 | 12 | 2022 |
ABM125 anti-IL-25 antibody pre-clinical development for viral asthma exacerbations identifies IL-25 mediated regulation of type-2-and anti-viral immunity N Bartlett, J Girkin, T Williams, T Vincent, C Jackson, K Alton, R Shimkets C31. MECHANISTIC INSIGHTS INTO LUNG INFECTION, A7759-A7759, 2018 | 5 | 2018 |
In vivo experimental models of infection and disease J Girkin, S Maltby, A Singanayagam, N Bartlett, P Mallia Rhinovirus Infections, 195-238, 2019 | 4 | 2019 |
Rhinovirus infection induces secretion of endothelin-1 from airway epithelial cells in both in vitro and in vivo models ABC Dy, J Girkin, A Marrocco, A Collison, C Mwase, MJ O’Sullivan, ... Respiratory Research 24 (1), 205, 2023 | 3 | 2023 |
Is CC Chemokine Ligand 17 (TARC) Driving Disease Progression in Chronic Obstructive Pulmonary Disease? J Girkin American Journal of Respiratory Cell and Molecular Biology 66 (4), 358-360, 2022 | 3 | 2022 |
Emerging therapeutic approaches G McLean, J Girkin, R Solari Rhinovirus Infections, 239-263, 2019 | 2 | 2019 |
Upper respiratory tract OC43 infection model for investigating airway immune-modifying therapies JLN Girkin, NE Bryant, SL Loo, A Hsu, A Kanwal, TC Williams, S Maltby, ... American journal of respiratory cell and molecular biology 69 (6), 614-622, 2023 | 1 | 2023 |
Treatment of respiratory infection with a tlr2 agonist N Bartlett, J Girkin, D Jackson, W Zeng, I Holmes, C Demaison US Patent App. 16/495,829, 2020 | 1 | 2020 |
Upper Airway TLR2 Immune Modulators Prime Broad Respiratory Immunity Against Rhinovirus and Influenza Infection and Inhibit Subsequent Lung Inflammation NW Bartlett, J Girkin, CY Wong, G Deliyannis, W Zeng, C Demaison, ... D107. HOST PATHOGEN INTERACTIONS, A7803-A7803, 2018 | 1 | 2018 |
Human coronavirus OC43 nanobody neutralizes virus and protects mice from infection A Adair, LL Tan, J Feng, J Girkin, N Bryant, M Wang, F Mordant, LJ Chan, ... Journal of virology, e00531-24, 2024 | | 2024 |