Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield S Zolotukhin, BJ Byrne, E Mason, I Zolotukhin, M Potter, K Chesnut, ... Gene therapy 6 (6), 973-985, 1999 | 1591 | 1999 |
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of … C Burger, OS Gorbatyuk, MJ Velardo, CS Peden, P Williams, S Zolotukhin, ... Molecular Therapy 10 (2), 302-317, 2004 | 911 | 2004 |
A" humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells S Zolotukhin, M Potter, WW Hauswirth, J Guy, N Muzyczka Journal of virology 70 (7), 4646-4654, 1996 | 848 | 1996 |
Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses L Zhong, B Li, CS Mah, L Govindasamy, M Agbandje-McKenna, ... Proceedings of the National Academy of Sciences 105 (22), 7827-7832, 2008 | 730 | 2008 |
Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors S Zolotukhin, M Potter, I Zolotukhin, Y Sakai, S Loiler, TJ Fraites Jr, ... Methods 28 (2), 158-167, 2002 | 671 | 2002 |
Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus JG Flannery, S Zolotukhin, MI Vaquero, MM LaVail, N Muzyczka, ... Proceedings of the National Academy of Sciences 94 (13), 6916-6921, 1997 | 509 | 1997 |
High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors H Petrs-Silva, A Dinculescu, Q Li, SH Min, V Chiodo, JJ Pang, L Zhong, ... Molecular therapy 17 (3), 463-471, 2009 | 493 | 2009 |
Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding SR Opie, KH Warrington Jr, M Agbandje-McKenna, S Zolotukhin, ... Journal of virology 77 (12), 6995-7006, 2003 | 444 | 2003 |
Humanized green fluorescent protein genes and methods S Zolotukhin, N Muzyczka, WW Hauswirth US Patent 5,874,304, 1999 | 355 | 1999 |
Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters AL Peel, S Zolotukhin, GW Schrimsher, N Muzyczka, PJ Reier Gene therapy 4 (1), 16-24, 1997 | 340 | 1997 |
Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors RL Klein, EM Meyer, AL Peel, S Zolotukhin, C Meyers, N Muzyczka, ... Experimental neurology 150 (2), 183-194, 1998 | 339 | 1998 |
Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats S Shklyaev, G Aslanidi, M Tennant, V Prima, E Kohlbrenner, V Kroutov, ... Proceedings of the National Academy of Sciences 100 (24), 14217-14222, 2003 | 318 | 2003 |
Structure of adeno-associated virus serotype 8, a gene therapy vector HJ Nam, MD Lane, E Padron, B Gurda, R McKenna, E Kohlbrenner, ... Journal of virology 81 (22), 12260-12271, 2007 | 299 | 2007 |
Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression LI Zhong, B Li, G Jayandharan, CS Mah, L Govindasamy, ... Virology 381 (2), 194-202, 2008 | 279 | 2008 |
Adeno-associated virus type 2 VP2 capsid protein is nonessential and can tolerate large peptide insertions at its N terminus KH Warrington Jr, OS Gorbatyuk, JK Harrison, SR Opie, S Zolotukhin, ... Journal of virology 78 (12), 6595-6609, 2004 | 277 | 2004 |
Structural insight into the unique properties of adeno-associated virus serotype 9 MA DiMattia, HJ Nam, K Van Vliet, M Mitchell, A Bennett, BL Gurda, ... Journal of virology 86 (12), 6947-6958, 2012 | 246 | 2012 |
Regulation of adiponectin and leptin gene expression in white and brown adipose tissues: influence of β3-adrenergic agonists, retinoic acid, leptin and fasting Y Zhang, M Matheny, S Zolotukhin, N Tumer, PJ Scarpace Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2002 | 227 | 2002 |
[48] Production and purification of recombinant adeno-associated virus WW Hauswirth, AS Lewin, S Zolotukhin, N Muzyczka Methods in enzymology 316, 743-761, 2000 | 208 | 2000 |
High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap JE Conway, CMJ Ap Rhys, I Zolotukhin, S Zolotukhin, N Muzyczka, ... Gene Therapy 6 (6), 986-993, 1999 | 202 | 1999 |
A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis L Zhong, W Zhao, J Wu, B Li, S Zolotukhin, L Govindasamy, ... Molecular Therapy 15 (7), 1323-1330, 2007 | 198 | 2007 |