| Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP J De Rooij, FJT Zwartkruis, MHG Verheijen, RH Cool, SMB Nijman, ... Nature 396 (6710), 474-477, 1998 | 2456 | 1998 |
| The multiple signaling systems regulating virulence in Pseudomonas aeruginosa P Nadal Jimenez, G Koch, JA Thompson, KB Xavier, RH Cool, WJ Quax Microbiology and Molecular Biology Reviews 76 (1), 46-65, 2012 | 881 | 2012 |
| Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs J De Rooij, H Rehmann, M van Triest, RH Cool, A Wittinghofer, JL Bos Journal of Biological Chemistry 275 (27), 20829-20836, 2000 | 524 | 2000 |
| Quorum Quenching by an N-Acyl-Homoserine Lactone Acylase from Pseudomonas aeruginosa PAO1 CF Sio, LG Otten, RH Cool, SP Diggle, PG Braun, R Bos, M Daykin, ... Infection and immunity 74 (3), 1673-1682, 2006 | 403 | 2006 |
| Kinetic Analysis by Fluorescence of the Interaction between Ras and the Catalytic Domain of the Guanine Nucleotide Exchange Factor Cdc25Mm C Lenzen, RH Cool, H Prinz, J Kuhlmann, A Wittinghofer Biochemistry 37 (20), 7420-7430, 1998 | 341 | 1998 |
| Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor AM van der Sloot, V Tur, E Szegezdi, MM Mullally, RH Cool, A Samali, ... Proceedings of the National Academy of Sciences 103 (23), 8634-8639, 2006 | 216 | 2006 |
| Stimulation of gene induction and cell growth by the Ras effector Rlf RMF Wolthuis, ND De Ruiter, RH Cool, JL Bos The EMBO journal, 1997 | 210 | 1997 |
| [10] Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements C Lenzen, RH Cool, A Wittinghofer Methods in enzymology 255, 95-109, 1995 | 189 | 1995 |
| Activation of the small GTPase Ral in platelets RMF Wolthuis, B Franke, M Van Triest, B Bauer, RH Cool, JH Camonis, ... Molecular and cellular biology, 1998 | 176 | 1998 |
| RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein. RM Wolthuis, B Bauer, LJ Van't Veer, AM de Vries-Smits, RH Cool, ... Oncogene 13 (2), 353-362, 1996 | 173 | 1996 |
| PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2 J de Rooij, NM Boenink, M van Triest, RH Cool, A Wittinghofer, JL Bos Journal of Biological Chemistry 274 (53), 38125-38130, 1999 | 155 | 1999 |
| Role of PvdQ in Pseudomonas aeruginosa virulence under iron-limiting conditions PN Jimenez, G Koch, E Papaioannou, M Wahjudi, J Krzeslak, T Coenye, ... Microbiology 156 (1), 49-59, 2010 | 128 | 2010 |
| Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A (S17N) N van den Berghe, RH Cool, G Horn, A Wittinghofer Oncogene 15 (7), 845-850, 1997 | 123 | 1997 |
| Elongation factor Tu: a molecular switch in protein biosynthesis A Weijland, K Harmark, RH Cool, PH Anborgh, A Parmeggiani Molecular microbiology 6 (6), 683-688, 1992 | 106 | 1992 |
| Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1 A Görlach, U Berchner-Pfannschmidt, C Wotzlaw, RH Cool, J Fandrey, ... Thrombosis and haemostasis 89 (05), 926-935, 2003 | 105 | 2003 |
| PA0305 of Pseudomonas aeruginosa is a quorum quenching acylhomoserine lactone acylase belonging to the Ntn hydrolase superfamily M Wahjudi, E Papaioannou, O Hendrawati, AHG van Assen, ... Microbiology 157 (7), 2042-2055, 2011 | 104 | 2011 |
| Biochemical and biological consequences of changing the specificity of p21ras from guanosine to xanthosine nucleotides. G Schmidt, C Lenzen, I Simon, R Deuter, RH Cool, RS Goody, ... Oncogene 12 (1), 87-96, 1996 | 102 | 1996 |
| The Ras mutant D119N is both dominant negative and activated RH Cool, G Schmidt, CU Lenzen, H Prinz, D Vogt, A Wittinghofer Molecular and cellular biology, 1999 | 101 | 1999 |
| Effector recognition by the small GTP-binding proteins Ras and Ral B Bauer, G Mirey, IR Vetter, JA Garcıa-Ranea, A Valencia, A Wittinghofer, ... Journal of Biological Chemistry 274 (25), 17763-17770, 1999 | 100 | 1999 |
| Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants CR Reis, AM Van Der Sloot, A Natoni, E Szegezdi, R Setroikromo, ... Cell death & disease 1 (10), e83-e83, 2010 | 99 | 2010 |
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