A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-l-proline BJ Levin, YY Huang, SC Peck, Y Wei, A Martinez-Del Campo, JA Marks, ... Science 355 (6325), eaai8386, 2017 | 153 | 2017 |
A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia SC Peck, K Denger, A Burrichter, SM Irwin, EP Balskus, D Schleheck Proceedings of the National Academy of Sciences 116 (8), 3171-3176, 2019 | 148 | 2019 |
Evidence that the fosfomycin-producing epoxidase, HppE, is a non–heme-iron peroxidase C Wang, W Chang, Y Guo, H Huang, SC Peck, ME Pandelia, G Lin, H Liu, ... Science 342 (6161), 991-995, 2013 | 77 | 2013 |
Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology SC Peck, WA van der Donk Current opinion in chemical biology 17 (4), 580-588, 2013 | 69 | 2013 |
Structural basis for methylphosphonate biosynthesis DA Born, EC Ulrich, KS Ju, SC Peck, WA Van Der Donk, CL Drennan Science 358 (6368), 1336-1339, 2017 | 54 | 2017 |
Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes SC Peck, WA van der Donk JBIC Journal of Biological Inorganic Chemistry 22, 381-394, 2017 | 44 | 2017 |
On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase JT Whitteck, P Malova, SC Peck, RM Cicchillo, F Hammerschmidt, ... Journal of the American Chemical Society 133 (12), 4236-4239, 2011 | 41 | 2011 |
Oxygen-18 kinetic isotope effects of nonheme iron enzymes HEPD and MPnS support iron (III) superoxide as the hydrogen abstraction species H Zhu, SC Peck, F Bonnot, WA Van Der Donk, JP Klinman Journal of the American Chemical Society 137 (33), 10448-10451, 2015 | 39 | 2015 |
O–H activation by an unexpected ferryl intermediate during catalysis by 2-hydroxyethylphosphonate dioxygenase SC Peck, C Wang, LMK Dassama, B Zhang, Y Guo, LJ Rajakovich, ... Journal of the American Chemical Society 139 (5), 2045-2052, 2017 | 38 | 2017 |
Discovery and biosynthesis of phosphonate and phosphinate natural products SC Peck, J Gao, WA Van Der Donk Methods in enzymology 516, 101-123, 2012 | 32 | 2012 |
Mechanistic investigation of methylphosphonate synthase, a non-heme iron-dependent oxygenase HA Cooke, SC Peck, BS Evans, WA Van Der Donk Journal of the American Chemical Society 134 (38), 15660-15663, 2012 | 31 | 2012 |
Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase SC Peck, HA Cooke, RM Cicchillo, P Malova, F Hammerschmidt, SK Nair, ... Biochemistry 50 (30), 6598-6605, 2011 | 29 | 2011 |
A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase SC Peck, JR Chekan, EC Ulrich, SK Nair, WA Van Der Donk Journal of the American Chemical Society 137 (9), 3217-3220, 2015 | 27 | 2015 |
Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation V Agarwal, SC Peck, JH Chen, SA Borisova, JR Chekan, ... Chemistry & biology 21 (1), 125-135, 2014 | 23 | 2014 |
Synthetic phosphonic acids as potent tools to study phosphonate enzymology K Pallitsch, T Kalina, T Stanković Synlett 30 (07), 770-776, 2019 | 12 | 2019 |
Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin DJ Bougioukou, CP Ting, SC Peck, S Mukherjee, WA Van Der Donk Organic & biomolecular chemistry 17 (4), 822-829, 2019 | 9 | 2019 |
Stereochemistry of hydride transfer by group III alcohol dehydrogenases involved in phosphonate biosynthesis SC Peck, SY Kim, BS Evans, WA Van Der Donk MedChemComm 3 (8), 967-970, 2012 | 8 | 2012 |
Elucidating the Mechanism of CS Bond Cleavage in Isethionate Sulfite-Lyase C Dawson, S Peck, S Irwin, E Balskus, C Drennan PROTEIN SCIENCE 27, 195-196, 2018 | | 2018 |
Involvement of metal-superoxo species in iron and copper CH activating enzymes J Klinman, H Zhu, S Peck, F Bonnot, W van der Donk ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016 | | 2016 |
Mechanistic investigations of enzymes in phosphonate metabolism SC Peck University of Illinois at Urbana-Champaign, 2014 | | 2014 |