Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and … MA Abdelgawad, MB Labib, WAM Ali, G Kamel, AA Azouz, ... Bioorganic chemistry 78, 103-114, 2018 | 75 | 2018 |
Novel pyrimidine-pyridine hybrids: synthesis, cyclooxygenase inhibition, anti-inflammatory activity and ulcerogenic liability MA Abdelgawad, RB Bakr, AA Azouz Bioorganic Chemistry 77, 339-348, 2018 | 69 | 2018 |
Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and docking study PF Lamie, JN Philoppes, AA Azouz, NM Safwat Journal of enzyme inhibition and medicinal chemistry 32 (1), 805-820, 2017 | 67 | 2017 |
Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway FEM Ali, AA Azouz, AG Bakr, AM Abo-Youssef, RAM Hemeida Food and Chemical Toxicology 120, 294-304, 2018 | 56 | 2018 |
Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1, 3, 5-triazines: Confirmation of regiospecific pyrazole … HAH Elshemy, EKA Abdelall, AA Azouz, A Moawad, WAM Ali, NM Safwat European Journal of Medicinal Chemistry 127, 10-21, 2017 | 49 | 2017 |
Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis FEM Ali, AG Bakr, AM Abo-Youssef, AA Azouz, RAM Hemeida Life sciences 207, 50-60, 2018 | 44 | 2018 |
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1-phenylpyrazolo[3,4-d]pyrimidine derivatives RB Bakr, AA Azouz, KRA Abdellatif Journal of enzyme inhibition and medicinal chemistry 31 (sup2), 6-12, 2016 | 44 | 2016 |
1-(4-Methane(amino)sulfonylphenyl)-3-(4-substituted-phenyl)-5-(4-trifluoromethylphenyl)- 1H-2-pyrazolines/ pyrazoles as potential anti-inflammatory agents Khaled R.A. Abdellatif, Heba A.H. Elshemy, Amany A. Azoz Bioorganic Chemistry 63, 13-23, 2015 | 41 | 2015 |
Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo [4, 5-d] pyrimidine scaffold RB Bakr, AA Ghoneim, AA Azouz Bioorganic chemistry 88, 102964, 2019 | 29 | 2019 |
Benzbromarone mitigates cisplatin nephrotoxicity involving enhanced peroxisome proliferator-activated receptor-alpha (PPAR-α) expression EAN Abdel-Razek, AM Abo-Youssef, AA Azouz Life sciences 243, 117272, 2020 | 25 | 2020 |
Discovery of a COX-2 selective inhibitor hit with anti-inflammatory activity and gastric ulcer protective effect MA Abdelgawad, RB Bakr, AO El-Gendy, GM Kamel, AA Azouz, ... Future medicinal chemistry 9 (16), 1899-1912, 2017 | 21 | 2017 |
Aliskiren, tadalafil, and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freund's adjuvant arthritis model: Downregulation of IL-6/JAK2 … AA Azouz, E Saleh, AA Abo-Saif Saudi Pharmaceutical Journal 28 (9), 1101-1111, 2020 | 19 | 2020 |
Amlodipine alleviates cisplatin-induced nephrotoxicity in rats through gamma-glutamyl transpeptidase (GGT) enzyme inhibition, associated with regulation of Nrf2/HO-1, MAPK/NF … AA Azouz, EAN Abdel-Razek, AM Abo-Youssef Saudi Pharmaceutical Journal 28 (11), 1317-1325, 2020 | 16 | 2020 |
Docking study, synthesis, and anti-inflammatory potential of some new pyridopyrimidine-derived compounds MA Abdelgawad, MM Al-Sanea, A Musa, M Elmowafy, AK El-Damasy, ... Journal of Inflammation Research, 451-463, 2022 | 15 | 2022 |
Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybrids EKA Abdelall, AO Abdelhamid, AA Azouz Bioorganic & Medicinal Chemistry Letters 27 (18), 4358-4369, 2017 | 15 | 2017 |
Febuxostat attenuates testosterone-induced benign prostatic hyperplasia in rats via inhibiting JAK/STAT axis AM Abo-Youssef, H Afify, AA Azouz, HM Abdel-Rahman, AB Abdel-Naim, ... Life sciences 260, 118414, 2020 | 13 | 2020 |
Synthesis, Cyclooxygenase Inhibition, Anti‐Inflammatory Evaluation, and Ulcerogenic Liability of New 1, 3, 5‐Triarylpyrazoline Derivatives Possessing a Methanesulfonyl … KRA Abdellatif, WAA Fadaly, AA Azouz Archiv der Pharmazie 349 (10), 801-807, 2016 | 13 | 2016 |
Interference with megalin expression/endocytic function by montelukast mitigates gentamicin nephrotoxicity: Downregulation of ClC-5 expression AA Azouz, DA Hanna, AA Abo-Saif, BAS Messiha Saudi Pharmaceutical Journal 30 (2), 150-161, 2022 | 12 | 2022 |
The modulatory effects of cinnamaldehyde on uric acid level and IL-6/JAK1/STAT3 signaling as a promising therapeutic strategy against benign prostatic hyperplasia H Afify, AM Abo-Youssef, HM Abdel-Rahman, S Allam, AA Azouz Toxicology and Applied Pharmacology 402, 115122, 2020 | 11 | 2020 |
Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: modulation of uric acid/ERK/p38 MAPK and Nrf2/SOD3/GCLC signaling pathways AA Azouz, HA Omar, F Hersi, FEM Ali, AMMH Elkelawy Life Sciences 288, 120154, 2022 | 10 | 2022 |