Spleen tyrosine kinase–mediated autophagy is required for epithelial–mesenchymal plasticity and metastasis in breast cancer A Shinde, SD Hardy, D Kim, SS Akhand, MK Jolly, WH Wang, ... Cancer research 79 (8), 1831-1843, 2019 | 112 | 2019 |
Selection of DNA-encoded libraries to protein targets within and on living cells B Cai, D Kim, S Akhand, Y Sun, RJ Cassell, A Alpsoy, EC Dykhuizen, ... Journal of the American Chemical Society 141 (43), 17057-17061, 2019 | 99 | 2019 |
Modifying the charge state distribution of proteins in electrospray ionization mass spectrometry by chemical derivatization CJ Krusemark, BL Frey, PJ Belshaw, LM Smith Journal of the American Society for Mass Spectrometry 20, 1617-1625, 2009 | 99 | 2009 |
Mixed isotope photoaffinity reagents for identification of small‐molecule targets by mass spectrometry SM Lamos, CJ Krusemark, CJ McGee, M Scalf, LM Smith, PJ Belshaw Angewandte Chemie 118 (26), 4435-4439, 2006 | 64 | 2006 |
Optimization of ligands using focused DNA-encoded libraries to develop a selective, cell-permeable CBX8 chromodomain inhibitor S Wang, KE Denton, KF Hobbs, T Weaver, JMB McFarlane, KE Connelly, ... ACS chemical biology 15 (1), 112-131, 2019 | 62 | 2019 |
Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries KE Denton, CJ Krusemark MedChemComm 7 (10), 2020-2027, 2016 | 61 | 2016 |
Chemical derivatization of peptide carboxyl groups for highly efficient electron transfer dissociation BL Frey, DT Ladror, SB Sondalle, CJ Krusemark, AL Jue, JJ Coon, ... Journal of the American Society for Mass Spectrometry 24 (11), 1710-1721, 2013 | 56 | 2013 |
Robustness of in vitro selection assays of DNA-encoded peptidomimetic ligands to CBX7 and CBX8 KE Denton, S Wang, MC Gignac, N Milosevich, F Hof, EC Dykhuizen, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 23 (5), 417-428, 2018 | 53 | 2018 |
A potent, selective CBX2 chromodomain ligand and its cellular activity during prostate cancer neuroendocrine differentiation S Wang, A Alpsoy, S Sood, SC Ordonez‐Rubiano, A Dhiman, Y Sun, ... ChemBioChem 22 (13), 2335-2344, 2021 | 36 | 2021 |
Global amine and acid functional group modification of proteins CJ Krusemark, JT Ferguson, CD Wenger, NL Kelleher, PJ Belshaw Analytical chemistry 80 (3), 713-720, 2008 | 32 | 2008 |
Directed chemical evolution with an outsized genetic code CJ Krusemark, NP Tilmans, PO Brown, PB Harbury PloS one 11 (8), e0154765, 2016 | 31 | 2016 |
Sensing Enzymatic Activity by Exposure and Selection of DNA‐Encoded Probes RR Jetson, CJ Krusemark Angewandte Chemie International Edition 55 (33), 9562-9566, 2016 | 31 | 2016 |
Complete chemical modification of amine and acid functional groups of peptides and small proteins CJ Krusemark, BL Frey, LM Smith, PJ Belshaw Gel-Free Proteomics: Methods and Protocols, 77-91, 2011 | 26 | 2011 |
Ion–ion reactions with fixed-charge modified proteins to produce ions in a single, very high charge state BL Frey, CJ Krusemark, AR Ledvina, JJ Coon, PJ Belshaw, LM Smith International journal of mass spectrometry 276 (2-3), 136-143, 2008 | 26 | 2008 |
Ionizable isotopic labeling reagents for relative quantification by mass spectrometry LM Smith, MR Shortreed, BL Frey, MF Phillips, JJ Coon, SM Lamos, ... US Patent 7,982,070, 2011 | 19 | 2011 |
Covalent labelling of fusion proteins in live cells via an engineered receptor–ligand pair CJ Krusemark, PJ Belshaw Organic & Biomolecular Chemistry 5 (14), 2201-2204, 2007 | 18 | 2007 |
Application of a substrate-mediated selection with c-Src tyrosine kinase to a DNA-encoded chemical library D Kim, Y Sun, D Xie, KE Denton, H Chen, H Lin, MK Wendt, CB Post, ... Molecules 24 (15), 2764, 2019 | 16 | 2019 |
Multiplexed Small‐Molecule‐Ligand Binding Assays by Affinity Labeling and DNA Sequence Analysis B Cai, CJ Krusemark Angewandte Chemie International Edition 61 (3), e202113515, 2022 | 15 | 2022 |
A DNA-assisted immunoassay for enzyme activity via a DNA-linked, activity-based probe D Kim, RR Jetson, CJ Krusemark Chemical Communications 53 (68), 9474-9477, 2017 | 13 | 2017 |
Selection methods for proximity-dependent enrichment of ligands from DNA-encoded libraries using enzymatic fusion proteins B Cai, AB Mhetre, CJ Krusemark Chemical Science 14 (2), 245-250, 2023 | 11 | 2023 |