| Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity M Halliday, H Radford, Y Sekine, J Moreno, N Verity, J Le Quesne, ... Cell death & disease 6 (3), e1672, 2015 | 351 | 2015 |
| Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms L Wright, X Barril, B Dymock, L Sheridan, A Surgenor, M Beswick, ... Chemistry & biology 11 (6), 775-785, 2004 | 305 | 2004 |
| Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular … PA Brough, X Barril, J Borgognoni, P Chene, NGM Davies, B Davis, ... Journal of medicinal chemistry 52 (15), 4794-4809, 2009 | 192 | 2009 |
| Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B AF Zyryanova, F Weis, A Faille, AA Alard, A Crespillo-Casado, Y Sekine, ... Science 359 (6383), 1533-1536, 2018 | 191 | 2018 |
| Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets N Baurin, F Aboul-Ela, X Barril, B Davis, M Drysdale, B Dymock, H Finch, ... Journal of chemical information and computer sciences 44 (6), 2157-2166, 2004 | 184 | 2004 |
| Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution A Potter, V Oldfield, C Nunns, C Fromont, S Ray, CJ Northfield, CJ Bryant, ... Bioorganic & medicinal chemistry letters 20 (22), 6483-6488, 2010 | 102 | 2010 |
| Adenine derived inhibitors of the molecular chaperone HSP90—SAR explained through multiple X-ray structures B Dymock, X Barril, M Beswick, A Collier, N Davies, M Drysdale, A Fink, ... Bioorganic & medicinal chemistry letters 14 (2), 325-328, 2004 | 84 | 2004 |
| Reactivity of N-phenyl silylated ketenimines with electrophilic reagents C Fromont, S Masson Tetrahedron 55 (17), 5405-5418, 1999 | 43 | 1999 |
| High-loading resin beads for solid phase synthesis using triple branching symmetrical dendrimers C Fromont, M Bradley Chemical Communications, 283-284, 2000 | 38 | 2000 |
| Targeted delivery of lopinavir to HIV reservoirs in the mesenteric lymphatic system by lipophilic ester prodrug approach C Qin, YJ Chu, W Feng, C Fromont, S He, J Ali, JB Lee, A Zgair, M Berton, ... Journal of Controlled Release 329, 1077-1089, 2021 | 37 | 2021 |
| First Examples of a Claisen Rearrangement Stereocontrolled by a Sulfinyl Group: Synthesis of Novel α‐Sulfinyl Dithioesters C Alayrac, C Fromont, P Metzner, NT Anh Angewandte Chemie International Edition in English 36 (4), 371-374, 1997 | 33 | 1997 |
| Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease JG Baker, SM Gardiner, J Woolard, C Fromont, GP Jadhav, SN Mistry, ... The FASEB Journal 31 (7), 3150, 2017 | 19 | 2017 |
| Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model C Fromont, A Atzori, D Kaur, L Hashmi, G Greco, A Cabanillas, ... Journal of medicinal chemistry 63 (13), 6784-6801, 2020 | 17 | 2020 |
| Pyrazole-substituted benzimidazole derivatives for use in the treatment of cancer and autoimmune disorders DL Walmsley, MJ Drysdale, CJ Northfield, C Fromont US Patent App. 11/916,485, 2006 | 11 | 2006 |
| Using Esterase Selectivity to Determine the In Vivo Duration of Systemic Availability and Abolish Systemic Side Effects of Topical β-Blockers JG Baker, C Fromont, M Bruder, KSJ Thompson, B Kellam, SJ Hill, ... ACS Pharmacology & Translational Science 3 (4), 737-748, 2020 | 4 | 2020 |
| Die erste durch eine Sulfinylgruppe stereochemisch kontrollierte Claisen‐Umlagerung–Synthese von α‐Sulfinyldithioestern C Alayrac, C Fromont, P Metzner, NT Anh Angewandte Chemie 109 (4), 418-420, 1997 | 4 | 1997 |
| The First Examples of a Claisen Rearrangement Stereocontrolled by a Sulfur Center of Chirality C Fromont, P Metzner Phosphorus, Sulfur, and Silicon and the Related Elements 95 (1-4), 421-422, 1994 | 4 | 1994 |
| Supports for Solid‐Phase Synthesis C Fromont, V Pomel, M Bradley ChemInform 33 (49), no-no, 2002 | 3 | 2002 |
| Phosphorus, Sulfur Silicon Rel C Fromont, S Masson Elem 120, 397, 1997 | 3 | 1997 |
| Novel Ether Linked Compounds and Improved Treatments for Cardiac and Cardiovascular Disease JG Baker, PM Fischer, C Fromont, SM Gardiner, SJ Hill, G Jadhav, ... US Patent App. 13/983,462, 2012 | 2 | 2012 |
