关注
Hudson W. Coates
Hudson W. Coates
在 cam.ac.uk 的电子邮件经过验证
标题
引用次数
引用次数
年份
Cholesterol synthesis
AJ Brown, HW Coates, LJ Sharpe
Biochemistry of lipids, lipoproteins and membranes, 317-355, 2021
792021
Squalene monooxygenase: a journey to the heart of cholesterol synthesis
NK Chua, HW Coates, AJ Brown
Progress in lipid research 79, 101033, 2020
732020
A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate
H Yoshioka, HW Coates, NK Chua, Y Hashimoto, AJ Brown, K Ohgane
Proceedings of the National Academy of Sciences 117 (13), 7150-7158, 2020
652020
A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols
R Yan, P Cao, W Song, H Qian, X Du, HW Coates, X Zhao, Y Li, S Gao, ...
Science 371 (6533), eabb2224, 2021
602021
Post-translational control of the long and winding road to cholesterol
LJ Sharpe, HW Coates, AJ Brown
Journal of Biological Chemistry 295 (51), 17549-17559, 2020
432020
The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form
HW Coates, IM Capell-Hattam, AJ Brown
Journal of Biological Chemistry 296, 2021
222021
Cholesterol, cancer, and rebooting a treatment for athlete’s foot
NK Chua, HW Coates, AJ Brown
Science translational medicine 10 (437), eaat3741, 2018
142018
Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase
HW Coates, IM Capell-Hattam, EM Olzomer, X Du, R Farrell, H Yang, ...
Elife 12, e82843, 2023
122023
Consulting prostate cancer cohort data uncovers transcriptional control: regulation of the MARCH6 gene
HW Coates, NK Chua, AJ Brown
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2019
112019
A wolf in sheep's clothing: unmasking the lanosterol-induced degradation of HMG-CoA reductase
HW Coates, AJ Brown
Journal of Lipid Research 60 (10), 1643-1645, 2019
112019
The non catalytic protein ERG28 has a functional role in cholesterol synthesis and is coregulated transcriptionally
IM Capell-Hattam, NM Fenton, HW Coates, LJ Sharpe, AJ Brown
Journal of Lipid Research 63 (12), 2022
92022
The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues
HW Coates, TB Nguyen, X Du, EM Olzomer, R Farrell, FL Byrne, H Yang, ...
Journal of Biological Chemistry 300 (5), 2024
2024
Thesis abstract Substrate-induced activation of the rate-limiting cholesterol synthesis enzyme squalene monooxygenase
HW Coates
Journal and Proceedings of the Royal Society of New South Wales 156 (part 2 …, 2023
2023
Asters: rising stars in the cholesterol universe
HW Coates, AJ Brown
Nature Metabolism 5 (1), 16-18, 2023
2023
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