关注
Matthew Clifton
Matthew Clifton
Head, Structural and Biophysical Chemistry, Novartis
在 novartis.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Discovery of a cyclic boronic acid β-lactamase inhibitor (RPX7009) with utility vs class A serine carbapenemases
SJ Hecker, KR Reddy, M Totrov, GC Hirst, O Lomovskaya, DC Griffith, ...
Journal of medicinal chemistry 58 (9), 3682-3692, 2015
4272015
Lipocalin 2 promotes breast cancer progression
J Yang, DR Bielenberg, SJ Rodig, R Doiron, MC Clifton, AL Kung, ...
Proceedings of the National Academy of Sciences 106 (10), 3913-3918, 2009
3932009
Iron traffics in circulation bound to a siderocalin (Ngal)–catechol complex
G Bao, M Clifton, TM Hoette, K Mori, SX Deng, A Qiu, M Viltard, D Williams, ...
Nature chemical biology 6 (8), 602-609, 2010
3572010
Lipocalin 2 is required for pulmonary host defense against Klebsiella infection
YR Chan, JS Liu, DA Pociask, M Zheng, TA Mietzner, T Berger, TW Mak, ...
The Journal of Immunology 182 (8), 4947-4956, 2009
2632009
Combining functional and structural genomics to sample the essential Burkholderia structome
L Baugh, LA Gallagher, R Patrapuvich, MC Clifton, AS Gardberg, ...
PloS one 8 (1), e53851, 2013
1412013
The Siderocalin/Enterobactin Interaction: A Link between Mammalian Immunity and Bacterial Iron Transport1
RJ Abergel, MC Clifton, JC Pizarro, JA Warner, DK Shuh, RK Strong, ...
Journal of the American Chemical Society 130 (34), 11524-11534, 2008
1312008
Increasing the structural coverage of tuberculosis drug targets
L Baugh, I Phan, DW Begley, MC Clifton, B Armour, DM Dranow, ...
Tuberculosis 95 (2), 142-148, 2015
1232015
Siderocalins: siderophore-binding proteins of the innate immune system
MC Clifton, C Corrent, RK Strong
Biometals 22, 557-564, 2009
932009
Siderocalin/Lcn2/NGAL/24p3 does not drive apoptosis through gentisic acid mediated iron withdrawal in hematopoietic cell lines
C Correnti, V Richardson, AK Sia, AD Bandaranayake, M Ruiz, ...
Public Library of Science 7 (8), e43696, 2012
502012
Siderocalin outwits the coordination chemistry of vibriobactin, a siderophore of Vibrio cholerae
BE Allred, C Correnti, MC Clifton, RK Strong, KN Raymond
ACS chemical biology 8 (9), 1882-1887, 2013
462013
Galline Ex-FABP is an antibacterial siderocalin and a lysophosphatidic acid sensor functioning through dual ligand specificities
C Correnti, MC Clifton, RJ Abergel, B Allred, TM Hoette, M Ruiz, ...
Structure 19 (12), 1796-1806, 2011
452011
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy
S Bonazzi, E d’Hennezel, REJ Beckwith, L Xu, A Fazal, A Magracheva, ...
Cell Chemical Biology 30 (3), 235-247. e12, 2023
402023
A maltose-binding protein fusion construct yields a robust crystallography platform for MCL1
MC Clifton, DM Dranow, A Leed, B Fulroth, JW Fairman, J Abendroth, ...
PLoS One 10 (4), e0125010, 2015
382015
The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease
BK Kaiser, MC Clifton, BW Shen, BL Stoddard
Structure 17 (10), 1368-1376, 2009
382009
Immune Interference in Mycobacterium tuberculosis Intracellular Iron Acquisition through Siderocalin Recognition of Carboxymycobactins
TM Hoette, MC Clifton, AM Zawadzka, MA Holmes, RK Strong, ...
ACS chemical biology 6 (12), 1327-1331, 2011
332011
Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg2+–GDP
DA Serbzhinskiy, MC Clifton, B Sankaran, BL Staker, TE Edwards, ...
Acta Crystallographica Section F: Structural Biology Communications 71 (5 …, 2015
312015
Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands
MC Clifton, PB Rupert, TM Hoette, KN Raymond, RJ Abergel, RK Strong
Journal of Structural Biology: X 2, 100008, 2019
252019
Single diastereomer of a macrolactam core binds specifically to myeloid cell leukemia 1 (MCL1)
C Fang, B D’Souza, CF Thompson, MC Clifton, JW Fairman, B Fulroth, ...
ACS medicinal chemistry letters 5 (12), 1308-1312, 2014
252014
In vitro reassembly of the ribose ATP-binding cassette transporter reveals a distinct set of transport complexes
MC Clifton, MJ Simon, SK Erramilli, H Zhang, J Zaitseva, MA Hermodson, ...
Journal of Biological Chemistry 290 (9), 5555-5565, 2015
212015
NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts
D Zhang, HM Harris, J Chen, J Judy, G James, A Kelly, J McIntosh, ...
Blood 141 (13), 1584-1596, 2023
192023
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