| NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis SA Eccles, A Massey, FI Raynaud, SY Sharp, G Box, M Valenti, ... Cancer research 68 (8), 2850-2860, 2008 | 543 | 2008 |
| 4, 5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer PA Brough, W Aherne, X Barril, J Borgognoni, K Boxall, JE Cansfield, ... Journal of medicinal chemistry 51 (2), 196-218, 2008 | 508 | 2008 |
| Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms L Wright, X Barril, B Dymock, L Sheridan, A Surgenor, M Beswick, ... Chemistry & biology 11 (6), 775-785, 2004 | 303 | 2004 |
| Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design BW Dymock, X Barril, PA Brough, JE Cansfield, A Massey, E McDonald, ... Journal of medicinal chemistry 48 (13), 4212-4215, 2005 | 278 | 2005 |
| SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies S Hart, KC Goh, V Novotny-Diermayr, CY Hu, H Hentze, YC Tan, B Madan, ... Leukemia 25 (11), 1751-1759, 2011 | 213 | 2011 |
| Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14, 19-dioxa-5, 7, 26-triaza-tetracyclo [19.3. 1.1 (2, 6). 1 (8, 12)] heptacosa-1 (25), 2 (26), 3, 5, 8, 10, 12 (27 … AD William, ACH Lee, S Blanchard, A Poulsen, EL Teo, H Nagaraj, E Tan, ... Journal of medicinal chemistry 54 (13), 4638-4658, 2011 | 200 | 2011 |
| Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular … PA Brough, X Barril, J Borgognoni, P Chene, NGM Davies, B Davis, ... Journal of medicinal chemistry 52 (15), 4794-4809, 2009 | 192 | 2009 |
| Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets N Baurin, F Aboul-Ela, X Barril, B Davis, M Drysdale, B Dymock, H Finch, ... Journal of chemical information and computer sciences 44 (6), 2157-2166, 2004 | 183 | 2004 |
| Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues SY Sharp, C Prodromou, K Boxall, MV Powers, JL Holmes, G Box, ... Molecular cancer therapeutics 6 (4), 1198-1211, 2007 | 168 | 2007 |
| TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties KC Goh, V Novotny-Diermayr, S Hart, LC Ong, YK Loh, A Cheong, ... Leukemia 26 (2), 236-243, 2012 | 130 | 2012 |
| Novel approaches to the treatment of hepatitis C virus infection BW Dymock, PS Jones, FX Wilson Antiviral Chemistry and Chemotherapy 11 (2), 79-86, 2000 | 129 | 2000 |
| 4-Amino derivatives of the Hsp90 inhibitor CCT018159 X Barril, MC Beswick, A Collier, MJ Drysdale, BW Dymock, A Fink, K Grant, ... Bioorganic & medicinal chemistry letters 16 (9), 2543-2548, 2006 | 119 | 2006 |
| GYY4137, a novel water-soluble, H2S-releasing molecule P Rose, BW Dymock, PK Moore Methods in enzymology 554, 143-167, 2015 | 117 | 2015 |
| Anti-HCV nucleoside derivatives R Devos, B Dymock, C Hobbs, WR Jiang, J Martin, J Merrett, I Najera, ... US Patent App. 09/923,620, 2003 | 112 | 2003 |
| Emerging therapies for hepatitis C virus infection BW Dymock Emerging Drugs 6 (1), 13-42, 2001 | 110 | 2001 |
| 3-(5-Chloro-2, 4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone PA Brough, X Barril, M Beswick, BW Dymock, MJ Drysdale, L Wright, ... Bioorganic & medicinal chemistry letters 15 (23), 5197-5201, 2005 | 104 | 2005 |
| Discovery of Kinase Spectrum Selective Macrocycle (16E)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9 … AD William, ACH Lee, KC Goh, S Blanchard, A Poulsen, EL Teo, ... Journal of medicinal chemistry 55 (1), 169-196, 2012 | 103 | 2012 |
| Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans B Qabazard, L Li, J Gruber, MT Peh, LF Ng, SD Kumar, P Rose, CH Tan, ... Antioxidants & redox signaling 20 (16), 2621-2630, 2014 | 102 | 2014 |
| A fluorescence polarization assay for inhibitors of Hsp90 R Howes, X Barril, BW Dymock, K Grant, CJ Northfield, AGS Robertson, ... Analytical biochemistry 350 (2), 202-213, 2006 | 102 | 2006 |
| Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a … H Wang, N Yu, D Chen, KCL Lee, PL Lye, JWW Chang, W Deng, MCY Ng, ... Journal of medicinal chemistry 54 (13), 4694-4720, 2011 | 100 | 2011 |
