| Molecular mechanisms of ROS production and oxidative stress in diabetes P Newsholme, VF Cruzat, KN Keane, R Carlessi, PIH de Bittencourt Jr Biochemical Journal 473 (24), 4527-4550, 2016 | 811 | 2016 |
| Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β‐Cell Dysfunction KN Keane, VF Cruzat, R Carlessi, PIH de Bittencourt Jr, P Newsholme Oxidative medicine and cellular longevity 2015 (1), 181643, 2015 | 396 | 2015 |
| The chaperone balance hypothesis: The importance of the extracellular to intracellular HSP70 ratio to inflammation‐driven type 2 diabetes, the effect of exercise, and the … M Krause, TG Heck, A Bittencourt, SP Scomazzon, P Newsholme, R Curi, ... Mediators of inflammation 2015 (1), 249205, 2015 | 178 | 2015 |
| Metabolic fate of glutamine in lymphocytes, macrophages and neutrophils R Curi, P Newsholme, TC Pithon-Curi, M Pires-de-Melo, C Garcia, ... Brazilian Journal of Medical and Biological Research 32, 15-21, 1999 | 148 | 1999 |
| HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain? TG Heck, CM Schöler, PIH de Bittencourt Cell biochemistry and function 29 (3), 215-226, 2011 | 137 | 2011 |
| Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide P Newsholme, PI Homem De Bittencourt Jr, C O'Hagan, G De Vito, ... Clinical Science 118 (5), 341-349, 2010 | 130 | 2010 |
| LipoCardium: endothelium-directed cyclopentenone prostaglandin-based liposome formulation that completely reverses atherosclerotic lesions PIH de Bittencourt Jr, DJ Lagranha, A Maslinkiewicz, SM Senna, ... Atherosclerosis 193 (2), 245-258, 2007 | 108 | 2007 |
| GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation R Carlessi, Y Chen, J Rowlands, VF Cruzat, KN Keane, L Egan, ... Scientific reports 7 (1), 2661, 2017 | 104 | 2017 |
| Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression FC Di Naso, RR Porto, HS Fillmann, L Maggioni, AV Padoin, RJ Ramos, ... Obesity (Silver Spring, Md.), 2014 | 100 | 2014 |
| L-arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge MS Krause, NH McClenaghan, PR Flatt, PIH de Bittencourt, C Murphy, ... Journal of Endocrinology 211 (1), 87-97, 2011 | 99 | 2011 |
| Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia VF Cruzat, A Bittencourt, SP Scomazzon, JSM Leite, PIH de Bittencourt Jr, ... Nutrition 30 (5), 602-611, 2014 | 98 | 2014 |
| Regulatory principles in metabolism–then and now R Curi, P Newsholme, GN Marzuca-Nassr, HK Takahashi, SM Hirabara, ... Biochemical Journal 473 (13), 1845-1857, 2016 | 97 | 2016 |
| Acute exercise stimulates macrophage function: possible role of NF‐κB pathways EMS Silveira, MF Rodrigues, MS Krause, DR Vianna, BS Almeida, ... Cell biochemistry and function 25 (1), 63-73, 2007 | 96 | 2007 |
| Oral supplementations with free and dipeptide forms of L-glutamine in endotoxemic mice: effects on muscle glutamine-glutathione axis and heat shock proteins VF Cruzat, LC Pantaleão, J Donato Jr, PIH de Bittencourt Jr, J Tirapegui The Journal of nutritional biochemistry 25 (3), 345-352, 2014 | 93 | 2014 |
| The fat cell senescence hypothesis: a mechanism responsible for abrogating the resolution of inflammation in chronic disease P Newsholme, PIH de Bittencourt Jr Current Opinion in Clinical Nutrition & Metabolic Care 17 (4), 295-305, 2014 | 85 | 2014 |
| MRP1/GS‐X pump ATPase expression: is this the explanation for the cytoprotection of the heart against oxidative stress‐induced redox imbalance in comparison to skeletal muscle … MS Krause, LP Oliveira Jr, EMS Silveira, DR Vianna, JS Rossato, ... Cell biochemistry and function 25 (1), 23-32, 2007 | 79 | 2007 |
| Nitric oxide and fibrinogen in polycystic ovary syndrome: associations with insulin resistance and obesity SPM ácul AP, Andrade CD, Schwarz P, de Bittencourt PI Jr Eur J Obstet Gynecol Reprod Biol 133 (2), 191, 2007 | 78 | 2007 |
| High intensity interval training in the heat enhances exercise-induced lipid peroxidation, but prevents protein oxidation in physically active men AA Souza-Silva, E Moreira, D de Melo-Marins, CM Schöler, ... Temperature 3 (1), 167-175, 2016 | 75 | 2016 |
| Glycemic, inflammatory and oxidative stress responses to different high-intensity training protocols in type 1 diabetes: A randomized clinical trial JB Farinha, TR Ramis, AF Vieira, RCO Macedo, J Rodrigues-Krause, ... Journal of Diabetes and its Complications 32 (12), 1124-1132, 2018 | 74 | 2018 |
| Type 1 diabetes: can exercise impair the autoimmune event? The L‐arginine/glutamine coupling hypothesis M da Silva Krause, PIH de Bittencourt Jr Cell Biochemistry and Function: Cellular biochemistry and its modulation by …, 2008 | 70 | 2008 |
