| HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients W Guo, M Naujock, L Fumagalli, T Vandoorne, P Baatsen, R Boon, ... Nature communications 8 (1), 861, 2017 | 353 | 2017 |
| Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis H Wang, W Guo, J Mitra, PM Hegde, T Vandoorne, BJ Eckelmann, S Mitra, ... Nature Communications 9 (1), 3683, 2018 | 170 | 2018 |
| Axonal transport defects and neurodegeneration: molecular mechanisms and therapeutic implications W Guo, KS Dittlau, L Van Den Bosch Seminars in cell & developmental biology 99, 133-150, 2020 | 147 | 2020 |
| Efficient recombinase-mediated cassette exchange in hPSCs to study the hepatocyte lineage reveals AAVS1 locus-mediated transgene inhibition L Ordovás, R Boon, M Pistoni, Y Chen, E Wolfs, W Guo, R Sambathkumar, ... Stem cell reports 5 (5), 918-931, 2015 | 133 | 2015 |
| A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree W Xu, M Gu, L Sun, W Guo, H Zhu, J Ma, W Yuan, Y Kuang, B Ji, X Wu, ... The American Journal of Human Genetics 91 (6), 1088-1094, 2012 | 101 | 2012 |
| Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia S Raitano, L Ordovàs, L De Muynck, W Guo, I Espuny-Camacho, ... Stem cell reports 4 (1), 16-24, 2015 | 80 | 2015 |
| C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility L Fumagalli, FL Young, S Boeynaems, M De Decker, AR Mehta, ... Science Advances 7 (15), eabg3013, 2021 | 69 | 2021 |
| HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations R Fazal, S Boeynaems, A Swijsen, M De Decker, L Fumagalli, M Moisse, ... The EMBO journal 40 (7), e106177, 2021 | 68 | 2021 |
| Current advances and limitations in modeling ALS/FTD in a dish using induced pluripotent stem cells W Guo, L Fumagalli, R Prior, L Van Den Bosch Frontiers in neuroscience 11, 308102, 2017 | 66 | 2017 |
| Differentiation but not ALS mutations in FUS rewires motor neuron metabolism T Vandoorne, K Veys, W Guo, A Sicart, K Vints, A Swijsen, M Moisse, ... Nature communications 10 (1), 4147, 2019 | 54 | 2019 |
| Altered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations F Bursch, N Kalmbach, M Naujock, S Staege, R Eggenschwiler, ... Human Molecular Genetics 28 (17), 2835-2850, 2019 | 45 | 2019 |
| The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications W Guo, T Vandoorne, J Steyaert, KA Staats, L Van Den Bosch Brain 143 (6), 1651-1673, 2020 | 43 | 2020 |
| RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease H Wang, S Rangaswamy, M Kodavati, J Mitra, W Guo, EN Guerrero, ... Molecular Brain 12, 1-5, 2019 | 15 | 2019 |
| CRISPR/Cas9 screen in human iPSC‐derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity W Guo, H Wang, A Kumar Tharkeshwar, J Couthouis, E Braems, ... Alzheimer's & Dementia 19 (4), 1245-1259, 2023 | 14 | 2023 |
| CMT2Q-causing mutation in the Dhtkd1 gene lead to sensory defects, mitochondrial accumulation and altered metabolism in a knock-in mouse model C Luan, W Guo, L Chen, X Wei, Y He, Y Chen, S Dang, R Prior, X Li, ... Acta Neuropathologica Communications 8, 1-13, 2020 | 12 | 2020 |
| Therapeutic potential of HDAC6 in amyotrophic lateral sclerosis W Guo, L Van Den Bosch Cell stress 2 (1), 14, 2018 | 10 | 2018 |
| Targeting axonal transport: a new therapeutic avenue for ALS W Guo, L Fumagalli, L Van Den Bosch Amyotrophic Lateral Sclerosis-Recent Advances and Therapeutic Challenges, 2020 | 6 | 2020 |
| Efficient recombinase-mediated cassette exchange in hPSCs to study the hepatocyte lineage reveals AAVS1 locus-mediated transgene inhibition L Ordovás, R Boon, M Pistoni, Y Chen, E Wolfs, W Guo, R Sambathkumar, ... Stem Cell Reports 10 (2), 673, 2018 | 5 | 2018 |
| lncRNA Sequencing Reveals Neurodegeneration-associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists In Motor Neurons VE Provasek, M Kodavati, W Guo, H Wang, I Boldogh, L Van Den Bosch, ... Cells 12 (20), 2461, 2023 | 1 | 2023 |
| FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration M Kodavati, H Wang, W Guo, J Mitra, PM Hegde, V Provasek, VHM Rao, ... Research Square, 2023 | 1 | 2023 |
