Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy GP Gao, MR Alvira, L Wang, R Calcedo, J Johnston, JM Wilson Proceedings of the National Academy of Sciences 99 (18), 11854-11859, 2002 | 1992 | 2002 |
Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer SE Raper, N Chirmule, FS Lee, NA Wivel, A Bagg, G Gao, JM Wilson, ... Molecular genetics and metabolism 80 (1-2), 148-158, 2003 | 1908 | 2003 |
Adeno-associated virus vector as a platform for gene therapy delivery D Wang, PWL Tai, G Gao Nature reviews Drug discovery 18 (5), 358-378, 2019 | 1887 | 2019 |
Clades of Adeno-associated viruses are widely disseminated in human tissues G Gao, LH Vandenberghe, MR Alvira, Y Lu, R Calcedo, X Zhou, ... Journal of virology 78 (12), 6381-6388, 2004 | 1370 | 2004 |
Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo H Yin, CQ Song, JR Dorkin, LJ Zhu, Y Li, Q Wu, A Park, J Yang, S Suresh, ... Nature biotechnology 34 (3), 328-333, 2016 | 961 | 2016 |
Viral vector platforms within the gene therapy landscape JT Bulcha, Y Wang, H Ma, PWL Tai, G Gao Signal transduction and targeted therapy 6 (1), 53, 2021 | 900 | 2021 |
Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis KJ Fisher, GP Gao, MD Weitzman, R DeMatteo, JF Burda, JM Wilson Journal of virology 70 (1), 520-532, 1996 | 877 | 1996 |
Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses R Calcedo, LH Vandenberghe, G Gao, J Lin, JM Wilson The Journal of infectious diseases 199 (3), 381-390, 2009 | 874 | 2009 |
Gene therapy vectors based on adeno-associated virus type 1 W Xiao, N Chirmule, SC Berta, B McCullough, G Gao, JM Wilson Journal of virology 73 (5), 3994-4003, 1999 | 756 | 1999 |
New recombinant serotypes of AAV vectors G Gao, LH Vandenberghe, JM Wilson Current gene therapy 5 (3), 285-297, 2005 | 614 | 2005 |
Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy GP Gao, Y Yang, JM Wilson Journal of virology 70 (12), 8934-8943, 1996 | 493 | 1996 |
Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages Y Zhang, N Chirmule, G Gao, R Qian, M Croyle, B Joshi, J Tazelaar, ... Molecular Therapy 3 (5), 697-707, 2001 | 483 | 2001 |
Adeno-associated viruses undergo substantial evolution in primates during natural infections G Gao, MR Alvira, S Somanathan, Y Lu, LH Vandenberghe, JJ Rux, ... Proceedings of the National Academy of Sciences 100 (10), 6081-6086, 2003 | 469 | 2003 |
A Pilot Study of In Vivo Liver-Directed Gene Transfer with an Adenoviral Vector in Partial Ornithine Transcarbamylase Deficiency SE Raper, M Yudkoff, N Chirmule, GP Gao, F Nunes, ZJ Haskal, EE Furth, ... Human gene therapy 13 (1), 163-175, 2002 | 461 | 2002 |
Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors MA Schnell, Y Zhang, J Tazelaar, G Gao, QC Yu, R Qian, SJ Chen, ... Molecular Therapy 3 (5), 708-722, 2001 | 446 | 2001 |
Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column A Auricchio, M Hildinger, E O'Connor, GP Gao, JM Wilson Human gene therapy 12 (1), 71-76, 2001 | 422 | 2001 |
Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor JM Wilson, G Gao, MR Alvira, LH Vandenberghe US Patent 7,906,111, 2011 | 410 | 2011 |
Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses D Wang, H Mou, S Li, Y Li, S Hough, K Tran, J Li, H Yin, DG Anderson, ... Human gene therapy 26 (7), 432-442, 2015 | 400 | 2015 |
Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer X Ye, VM Rivera, P Zoltick, F Cerasoli Jr, MA Schnell, G Gao, JV Hughes, ... Science 283 (5398), 88-91, 1999 | 395 | 1999 |
Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver N Tao, GP Gao, M Parr, J Johnston, T Baradet, JM Wilson, J Barsoum, ... Molecular therapy 3 (1), 28-35, 2001 | 392 | 2001 |