| Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers RL Anderson, DV Trivedi, SS Sarkar, M Henze, W Ma, H Gong, ... Proceedings of the National Academy of Sciences 115 (35), E8143-E8152, 2018 | 308 | 2018 |
| The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations S Nag, DV Trivedi, SS Sarkar, AS Adhikari, MS Sunitha, S Sutton, ... Nature structural & molecular biology 24 (6), 525-533, 2017 | 202 | 2017 |
| Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light DV Trivedi, AS Adhikari, SS Sarkar, KM Ruppel, JA Spudich Biophysical reviews 10 (1), 27-48, 2018 | 145 | 2018 |
| SETD3 is an actin histidine methyltransferase that prevents primary dystocia AW Wilkinson, J Diep, S Dai, S Liu, YS Ooi, D Song, TM Li, JR Horton, ... Nature 565 (7739), 372-376, 2019 | 141 | 2019 |
| The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin SS Sarkar, DV Trivedi, MM Morck, AS Adhikari, SN Pasha, KM Ruppel, ... Science advances 6 (14), eaax0069, 2020 | 79 | 2020 |
| Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin JA Spudich, T Aksel, SR Bartholomew, S Nag, M Kawana, EC Yu, ... Journal of Experimental Biology 219 (2), 161-167, 2016 | 77 | 2016 |
| To lie or not to lie: Super-relaxing with myosins S Nag, DV Trivedi Elife 10, e63703, 2021 | 76 | 2021 |
| β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity AS Adhikari, DV Trivedi, SS Sarkar, D Song, KB Kooiker, D Bernstein, ... Nature communications 10 (1), 2685, 2019 | 69 | 2019 |
| The myosin family of mechanoenzymes: from mechanisms to therapeutic approaches DV Trivedi, S Nag, A Spudich, KM Ruppel, JA Spudich Annual review of biochemistry 89 (1), 667-693, 2020 | 62 | 2020 |
| Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V DV Trivedi, JM Muretta, AM Swenson, JP Davis, DD Thomas, CM Yengo Proceedings of the National Academy of Sciences 112 (47), 14593-14598, 2015 | 57 | 2015 |
| Magnesium modulates actin binding and ADP release in myosin motors AM Swenson, DV Trivedi, AA Rauscher, Y Wang, Y Takagi, BM Palmer, ... Journal of Biological Chemistry 289 (34), 23977-23991, 2014 | 50 | 2014 |
| Switch II mutants reveal coupling between the nucleotide-and actin-binding regions in myosin V DV Trivedi, C David, DJ Jacobs, CM Yengo Biophysical journal 102 (11), 2545-2555, 2012 | 38 | 2012 |
| Kinetics and thermodynamics of the rate-limiting conformational change in the actomyosin V mechanochemical cycle DJ Jacobs, D Trivedi, C David, CM Yengo Journal of molecular biology 407 (5), 716-730, 2011 | 36 | 2011 |
| Single residue variation in skeletal muscle myosin enables direct and selective drug targeting for spasticity and muscle stiffness M Gyimesi, ÁI Horváth, D Túrós, SK Suthar, M Pénzes, C Kurdi, L Canon, ... Cell 183 (2), 335-346. e13, 2020 | 31 | 2020 |
| Converter domain mutations in myosin alter structural kinetics and motor function LK Gunther, JA Rohde, W Tang, SD Walton, WC Unrath, DV Trivedi, ... Journal of Biological Chemistry 294 (5), 1554-1567, 2019 | 23 | 2019 |
| Magnesium impacts myosin V motor activity by altering key conformational changes in the mechanochemical cycle DV Trivedi, JM Muretta, AM Swenson, DD Thomas, CM Yengo Biochemistry 52 (27), 4710-4722, 2013 | 21 | 2013 |
| Mavacamten stabilizes a folded-back sequestered super-relaxed state of β-cardiac myosin RL Anderson, DV Trivedi, SS Sarkar, M Henze, W Ma, H Gong, ... BioRxiv, 266783, 2018 | 12 | 2018 |
| Beyond the myosin mesa: a potential unifying hypothesis on the underlying molecular basis of hyper-contractility caused by a majority of hypertrophic cardiomyopathy mutations S Nag, DV Trivedi, SS Sarkar, S Sutton, KM Ruppel, JA Spudich bioRxiv, 065508, 2016 | 7 | 2016 |
| A small-molecule myosin inhibitor as a targeted multi-stage antimalarial DV Trivedi, A Karabina, G Bergnes, A Racca, H Wander, S Jung, N Mittal, ... bioRxiv, 2022.09. 09.507317, 2022 | 5 | 2022 |
| Hypertrophic cardiomyopathy mutations at the folded-back sequestered β-cardiac myosin S1-S2 and S1-S1 interfaces release sequestered heads and increase myosin enzymatic activity AS Adhikari, DV Trivedi, SS Sarkar, D Song, KB Kooiker, D Bernstein, ... BioRxiv, 537159, 2019 | 5 | 2019 |
