Developments in anti-complement therapy; from disease to clinical trial CL Harris, RB Pouw, D Kavanagh, R Sun, D Ricklin Molecular Immunology 102, 89-119, 2018 | 89 | 2018 |
Tipping the balance: intricate roles of the complement system in disease and therapy RB Pouw, D Ricklin Seminars in Immunopathology 43 (6), 757-771, 2021 | 85 | 2021 |
Of mice and men: the factor H protein family and complement regulation RB Pouw, DW Vredevoogd, TW Kuijpers, D Wouters Molecular Immunology 67 (1), 12-20, 2015 | 64 | 2015 |
Self-damage caused by dysregulation of the complement alternative pathway: relevance of the factor H protein family P Sánchez-Corral, RB Pouw, M López-Trascasa, M Józsi Frontiers in Immunology 9, 1607, 2018 | 63 | 2018 |
FHR-1 and FHR-2 form homo- and heterodimers, while FHR-5 circulates only as homodimer in human plasma AE van Beek, RB Pouw, MC Brouwer, G van Mierlo, J Geissler, ... Frontiers in Immunology 8, 1328, 2017 | 51 | 2017 |
Complement factor H-related protein 3 serum levels are low compared to factor H and mainly determined by gene copy number variation in CFHR3 RB Pouw, MC Brouwer, J Geissler, LV van Herpen, SS Zeerleder, ... PLoS ONE 11 (3), e0152164, 2016 | 47 | 2016 |
TFPI inhibits lectin pathway of complement activation by direct interaction with MASP‐2 MP Keizer, RB Pouw, AM Kamp, S Patiwael, G Marsman, MH Hart, ... European Journal of Immunology 45 (2), 544-550, 2015 | 36 | 2015 |
Complement regulator FHR-3 is elevated either locally or systemically in a selection of autoimmune diseases N Schäfer, A Grosche, J Reinders, SM Hauck, RB Pouw, TW Kuijpers, ... Frontiers in Immunology 7, 542, 2016 | 31 | 2016 |
High complement factor H-related (FHR)-3 levels are associated with the atypical hemolytic uremic syndrome-risk allele CFHR3*B RB Pouw, I Gómez Delgado, A López Lera, S Rodríguez de Córdoba, ... Frontiers in Immunology 9, 848, 2018 | 30 | 2018 |
Potentiation of complement regulator factor H protects human endothelial cells from complement attack in aHUS sera RB Pouw, MC Brouwer, M de Gast, AE van Beek, LP van den Heuvel, ... Blood Advances 3 (4), 621-632, 2019 | 27 | 2019 |
Complement factor H-related protein 4A is the dominant circulating splice variant of CFHR4 RB Pouw, MC Brouwer, AE Van Beek, M Józsi, D Wouters, TW Kuijpers Frontiers in Immunology 9, 729, 2018 | 23 | 2018 |
Complement factor H contributes to mortality in humans and mice with bacterial meningitis ES Kasanmoentalib, M Valls Serón, JY Engelen-Lee, MW Tanck, ... Journal of neuroinflammation 16, 1-14, 2019 | 17 | 2019 |
The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation ECW de Boer, AJF Thielen, JD Langereis, A Kamp, MC Brouwer, ... Clinical & translational immunology 12 (1), e1436, 2023 | 10 | 2023 |
Sweet turning bitter: Carbohydrate sensing of complement in host defence and disease R Hevey, RB Pouw, C Harris, D Ricklin British journal of pharmacology 178 (14), 2802-2822, 2021 | 8 | 2021 |
Complement activation drives antibody-mediated transfusion-related acute lung injury via macrophage trafficking and formation of NETs S van der Velden, TLJ van Osch, A Seghier, AEH Bentlage, JY Mok, ... Blood 143 (1), 79-91, 2024 | 7 | 2024 |
Evaluating the clinical utility of measuring levels of factor H and the related proteins P Banerjee, BRJ Veuskens, EG de Jorge, M Józsi, AJ Baeumner, ... Molecular Immunology 151, 166-182, 2022 | 6 | 2022 |
Complement-regulatory biomaterial coatings: Activity and selectivity profile of the factor H-binding peptide 5C6 C Bechtler, S Koutsogiannaki, E Umnyakova, A Hamid, A Gautam, ... Acta Biomaterialia 155, 123-138, 2023 | 5 | 2023 |
Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations V Kumar, RB Pouw, MI Autio, MG Sagmeister, ZY Phua, L Borghini, ... The American Journal of Human Genetics 109 (9), 1680-1691, 2022 | 4 | 2022 |
Low Levels of Factor H Family Proteins During Meningococcal Disease Indicate Systemic Processes Rather Than Specific Depletion by Neisseria meningitidis AE van Beek, RB Pouw, VJ Wright, N Sallah, D Inwald, C Hoggart, ... Frontiers in immunology 13, 876776, 2022 | 3 | 2022 |
Complement & disease: out of the shadow into the spotlight D Ricklin, RB Pouw Seminars in Immunopathology 43, 755-756, 2021 | 3 | 2021 |