Mechanism of heparin activation of antithrombin: Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of … UR Desai, M Petitou, I Björk, ST Olson Journal of Biological Chemistry 273 (13), 7478-7487, 1998 | 230 | 1998 |
Chemical sulfation of small molecules—Advances and challenges RA Al-Horani, UR Desai Tetrahedron 66 (16), 2907-2918, 2010 | 218 | 2010 |
Specificity studies on the heparin lyases from Flavobacterium heparinum UR Desai, HM Wang, RJ Linhardt Biochemistry 32 (32), 8140-8145, 1993 | 204 | 1993 |
New antithrombin‐based anticoagulants UR Desai Medicinal Research Reviews 24 (2), 151-181, 2004 | 203 | 2004 |
Substrate specificity of the heparin lyases from Flavobacterium heparinum UR Desai, HM Wang, RJ Linhardt Archives of Biochemistry and Biophysics 306 (2), 461-468, 1993 | 179 | 1993 |
Cytotoxic cell granule-mediated apoptosis: characterization of the macromolecular complex of granzyme B with serglycin SM Raja, B Wang, M Dantuluri, UR Desai, B Demeler, K Spiegel, ... Journal of Biological Chemistry 277 (51), 49523-49530, 2002 | 151 | 2002 |
Oligosaccharide composition of heparin and low-molecular-weight heparins by capillary electrophoresis UR Desai, HM Wang, SA Ampofo, RJ Linhardt Analytical biochemistry 213 (1), 120-127, 1993 | 125 | 1993 |
Antithrombotic and anticoagulant activities of a low molecular weight fucoidan by the subcutaneous route J Millet, SC Jouault, S Mauray, J Theveniaux, C Sternberg, BC Vidal, ... Thrombosis and haemostasis 81 (03), 391-395, 1999 | 124 | 1999 |
1, 2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH) X He, AME Reeve, UR Desai, GE Kellogg, KA Reynolds Antimicrobial agents and chemotherapy 48 (8), 3093-3102, 2004 | 116 | 2004 |
Assessing the structural integrity of a lyophilized protein in organic solvents UR Desai, AM Klibanov Journal of the American Chemical Society 117 (14), 3940-3945, 1995 | 115 | 1995 |
New developments in anticoagulants: past, present and future JI Weitz, J Harenberg Thrombosis and haemostasis 117 (07), 1283-1288, 2017 | 111 | 2017 |
Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions PRB Joseph, PD Mosier, UR Desai, K Rajarathnam Biochemical Journal 472 (1), 121-133, 2015 | 105 | 2015 |
A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids BL Henry, BH Monien, PE Bock, UR Desai Journal of biological chemistry 282 (44), 31891-31899, 2007 | 98 | 2007 |
Discovering small-molecule therapeutics against SARS-CoV-2 V Tiwari, JC Beer, NV Sankaranarayanan, M Swanson-Mungerson, ... Drug Discovery Today 25 (8), 1535-1544, 2020 | 96 | 2020 |
Mechanism of heparin activation of antithrombin: evidence for an induced-fit model of allosteric activation involving two interaction subsites UR Desai, M Petitou, I Björk, ST Olson Biochemistry 37 (37), 13033-13041, 1998 | 94 | 1998 |
Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa RA Al-Horani, P Ponnusamy, AY Mehta, D Gailani, UR Desai Journal of medicinal chemistry 56 (3), 867-878, 2013 | 92 | 2013 |
Novel chemo-enzymatic oligomers of cinnamic acids as direct and indirect inhibitors of coagulation proteinases BH Monien, BL Henry, A Raghuraman, M Hindle, UR Desai Bioorganic & medicinal chemistry 14 (23), 7988-7998, 2006 | 88 | 2006 |
Recent advances on plasmin inhibitors for the treatment of fibrinolysis‐related disorders RA Al‐Horani, UR Desai Medicinal research reviews 34 (6), 1168-1216, 2014 | 86 | 2014 |
Interaction of heparin with synthetic antithrombin III peptide analogues J Bae, UR Desai, A Pervin, EEO Caldwell, JM Weiler, RJ Linhardt Biochemical Journal 301 (1), 121-129, 1994 | 84 | 1994 |
Finding a needle in a haystack: development of a combinatorial virtual screening approach for identifying high specificity heparin/heparan sulfate sequence (s) A Raghuraman, PD Mosier, UR Desai Journal of medicinal chemistry 49 (12), 3553-3562, 2006 | 83 | 2006 |