RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF (V600E) PI Poulikakos, Y Persaud, M Janakiraman, X Kong, C Ng, G Moriceau, ... Nature 480 (7377), 387-390, 2011 | 1649 | 2011 |
Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas P Lito, CA Pratilas, EW Joseph, M Tadi, E Halilovic, M Zubrowski, ... Cancer cell 22 (5), 668-682, 2012 | 599 | 2012 |
The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner EW Joseph, CA Pratilas, PI Poulikakos, M Tadi, W Wang, BS Taylor, ... Proceedings of the National Academy of Sciences 107 (33), 14903-14908, 2010 | 511 | 2010 |
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors D Ercan, C Xu, M Yanagita, CS Monast, CA Pratilas, J Montero, ... Cancer discovery 2 (10), 934-947, 2012 | 327 | 2012 |
Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis F Liu, G Cheng, PJ Hamard, S Greenblatt, L Wang, N Man, F Perna, H Xu, ... The Journal of clinical investigation 125 (9), 3532-3544, 2015 | 149 | 2015 |
Identification of unique MEK-dependent genes in GNAQ mutant uveal melanoma involved in cell growth, tumor cell invasion, and MEK resistance G Ambrosini, CA Pratilas, LX Qin, M Tadi, O Surriga, RD Carvajal, ... Clinical Cancer Research 18 (13), 3552-3561, 2012 | 117 | 2012 |
Gα13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation A Kumar, KN Kremer, D Dominguez, M Tadi, KE Hedin The Journal of Immunology 186 (2), 951-958, 2011 | 74 | 2011 |
CARM1 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis SM Greenblatt, N Man, PJ Hamard, T Asai, D Karl, C Martinez, D Bilbao, ... Cancer cell 33 (6), 1111-1127. e5, 2018 | 65 | 2018 |
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors. Cancer Discov. 2012; 2: 934–947. doi: 10.1158/2159-8290 D Ercan, C Xu, M Yanagita, CS Monast, CA Pratilas, J Montero, ... CD-12-0103.[Europe PMC free article][Abstract][CrossRef][Google Scholar], 2012 | 39 | 2012 |
Loss of p300 accelerates MDS-associated leukemogenesis G Cheng, F Liu, T Asai, F Lai, N Man, H Xu, S Chen, S Greenblatt, ... Leukemia 31 (6), 1382-1390, 2017 | 38 | 2017 |
Stoichiometry of LTβR binding to LIGHT J Eldredge, S Berkowitz, AF Corin, ES Day, D Hayes, W Meier, K Strauch, ... Biochemistry 45 (33), 10117-10128, 2006 | 24 | 2006 |
Defining the effects of MAPK pathway inhibition in human immune cells M Callahan Perspectives in melanoma XV, 2011 | 3 | 2011 |
Effect of milk supplemented with mulberry leaf extract, lipids and fiber on glycemic and insulin responses to a high-carbohydrate meal A Cherta-Murillo, H Xu, N Moullan, M Tadi, F Huang, ... Clinical Nutrition ESPEN 58, 730-731, 2023 | | 2023 |
Feedback dependent suppression of mitogenic signaling and its effect on RAF inhibition in BRAFV600E melanomas. P Lito, C Pratilas, E Joseph, M Tadi, E Halilovic, M Zubrowski, A Huang, ... Cancer Research 73 (8_Supplement), 4630-4630, 2013 | | 2013 |
Relief of feedback inhibition of RTK and RAS signaling in V600E BRAF melanomas exposed to RAF inhibitors buffers their effects on signaling CA Pratilas, EW Joseph, M Tadi, PI Poulikakos, M Gabay, P Lito, W Wong, ... Cancer Research 72 (8_Supplement), 1223-1223, 2012 | | 2012 |
Abstract LB-428: RAS-independent dimerization of BRAF (V600E) splicing variants promotes resistance to RAF inhibitors PI Poulikakos, Y Persaud, M Janakiraman, X Kong, C Ng, G Moriceau, ... Cancer Research 72 (8_Supplement), LB-428-LB-428, 2012 | | 2012 |
MEK inhibitors prevent rebound reactivation of ERK signaling by the RAF inhibitor PLX4032 and enhance its antitumor activity CA Pratilas, EW Joseph, M Tadi, M Gabay, W Wong, E De Stanchina, ... Cancer Research 71 (8_Supplement), 4398-4398, 2011 | | 2011 |
Ashok Kumar, Kimberly N. Kremer, Daniel Dominguez M Tadi, KE Hedin | | 2010 |
The pan-RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF mutant-selective manner EW Joseph, CA Pratilas, PI Poulikakos, M Tadi, WQ Wang, BS Taylor, ... Cancer Research 70 (8_Supplement), 2521-2521, 2010 | | 2010 |
Abstract# 2908: Amplification of wild-type BRAF in melanoma is associated with activation of RAF-MEK-ERK signaling and MEK-dependence. E Blumenthal, P Poulikakos, M Tadi, O Grbovic-Huezo, B Taylor, ... Cancer Research 69 (9_Supplement), 2908-2908, 2009 | | 2009 |