Rational discovery of molecular glue degraders via scalable chemical profiling C Mayor-Ruiz, S Bauer, M Brand, Z Kozicka, M Siklos, H Imrichova, ... Nature chemical biology 16 (11), 1199-1207, 2020 | 228 | 2020 |
A genome-wide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors S Ruiz, C Mayor-Ruiz, V Lafarga, M Murga, M Vega-Sendino, S Ortega, ... Molecular cell 62 (2), 307-313, 2016 | 198 | 2016 |
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity GE Winter, B Radic, C Mayor-Ruiz, VA Blomen, C Trefzer, RK Kandasamy, ... Nature chemical biology 10 (9), 768-773, 2014 | 175 | 2014 |
Plasticity of the Cullin-RING ligase repertoire shapes sensitivity to ligand-induced protein degradation C Mayor-Ruiz, MG Jaeger, S Bauer, M Brand, C Sin, A Hanzl, AC Mueller, ... Molecular cell 75 (4), 849-858. e8, 2019 | 86 | 2019 |
A p53-dependent response limits the viability of mammalian haploid cells T Olbrich, C Mayor-Ruiz, M Vega-Sendino, C Gomez, S Ortega, S Ruiz, ... Proceedings of the National Academy of Sciences 114 (35), 9367-9372, 2017 | 77 | 2017 |
Chasing molecular glue degraders: screening approaches A Domostegui, L Nieto-Barrado, C Perez-Lopez, C Mayor-Ruiz Chemical Society Reviews 51 (13), 5498-5517, 2022 | 65 | 2022 |
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches NS Scholes, C Mayor-Ruiz, GE Winter Cell Chemical Biology 28 (7), 1048-1060, 2021 | 38 | 2021 |
Identification and characterization of cancer vulnerabilities via targeted protein degradation C Mayor-Ruiz, GE Winter Drug Discovery Today: Technologies 31, 81-90, 2019 | 32 | 2019 |
ERF deletion rescues RAS deficiency in mouse embryonic stem cells C Mayor-Ruiz, T Olbrich, M Drosten, E Lecona, M Vega-Sendino, ... Genes & Development 32 (7-8), 568-576, 2018 | 15 | 2018 |
Design principles for cyclin K molecular glue degraders Z Kozicka, DJ Suchyta, V Focht, G Kempf, G Petzold, M Jentzsch, C Zou, ... Nature Chemical Biology 20 (1), 93-102, 2024 | 14 | 2024 |
Biophysical and computational approaches to study ternary complexes: a ‘cooperative relationship’to rationalize targeted protein degradation JA Ward, C Perez‐Lopez, C Mayor‐Ruiz ChemBioChem 24 (10), e202300163, 2023 | 13 | 2023 |
TrapSeq: An RNA sequencing-based pipeline for the identification of gene-trap insertions in mammalian cells C Mayor-Ruiz, O Dominguez, O Fernandez-Capetillo Journal of molecular biology 429 (18), 2780-2789, 2017 | 11 | 2017 |
Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway L González, L Díaz, J Pous, B Baginski, A Duran-Corbera, M Scarpa, ... Nature Communications 14 (1), 3318, 2023 | 6 | 2023 |
Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling C Mayor-Ruiz, S Bauer, M Brand, Z Kozicka, M Siklos, H Imrichova, ... Nature Chemical Biology 17 (3), 361-361, 2021 | 5 | 2021 |
Molecular Glue Degraders: From Serendipity to Hunting and Design L Nieto‐Barrado, A Domostegui, C Mayor‐Ruiz Inducing Targeted Protein Degradation: From Chemical Biology to Drug …, 2023 | 2 | 2023 |
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP M Cigler, H Imrichova, F Frommelt, L Depta, A Rukavina, C Kagiou, ... bioRxiv, 2023.03. 15.532743, 2023 | 1 | 2023 |
Inside Cover: Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders (Angew. Chem. Int. Ed. 12/2024) BMG Barbosa, A Sfyaki, S Rafael, F José‐Duran, J Pous, ... Angewandte Chemie International Edition 63 (12), e202403450, 2024 | | 2024 |
Innentitelbild: Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders (Angew. Chem. 12/2024) BMG Barbosa, A Sfyaki, S Rafael, F José‐Duran, J Pous, ... Angewandte Chemie 136 (12), e202403450, 2024 | | 2024 |
Chemical rewiring of ubiquitination by degraders and their selectivity routes R Whelan, C Mayor-Ruiz Nature Structural & Molecular Biology 31 (2), 205-207, 2024 | | 2024 |
Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders BMG Barbosa, A Sfyaki, S Rafael, F José‐Duran, J Pous, ... Angewandte Chemie International Edition, e202316730, 2024 | | 2024 |