Principles and applications of halogen bonding in medicinal chemistry and chemical biology R Wilcken, MO Zimmermann, A Lange, AC Joerger, FM Boeckler Journal of medicinal chemistry 56 (4), 1363-1388, 2013 | 1223 | 2013 |
Structural biology of the tumor suppressor p53 AC Joerger, AR Fersht Annu. Rev. Biochem. 77 (1), 557-582, 2008 | 803 | 2008 |
The p53 pathway: origins, inactivation in cancer, and emerging therapeutic approaches AC Joerger, AR Fersht Annual review of biochemistry 85 (1), 375-404, 2016 | 649 | 2016 |
Structure–function–rescue: the diverse nature of common p53 cancer mutants AC Joerger, AR Fersht Oncogene 26 (15), 2226-2242, 2007 | 539 | 2007 |
The tumor suppressor p53: from structures to drug discovery AC Joerger, AR Fersht Cold Spring Harbor perspectives in biology 2 (6), a000919, 2010 | 465 | 2010 |
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug FM Boeckler, AC Joerger, G Jaggi, TJ Rutherford, DB Veprintsev, ... Proceedings of the National Academy of Sciences 105 (30), 10360-10365, 2008 | 438 | 2008 |
Structural basis for understanding oncogenic p53 mutations and designing rescue drugs AC Joerger, HC Ang, AR Fersht Proceedings of the National Academy of Sciences 103 (41), 15056-15061, 2006 | 378 | 2006 |
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases VN Uversky, V Davé, LM Iakoucheva, P Malaney, SJ Metallo, RR Pathak, ... Chemical reviews 114 (13), 6844-6879, 2014 | 290 | 2014 |
Small molecule induced reactivation of mutant p53 in cancer cells X Liu, R Wilcken, AC Joerger, IS Chuckowree, J Amin, J Spencer, ... Nucleic acids research 41 (12), 6034-6044, 2013 | 255 | 2013 |
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53 R Wilcken, X Liu, MO Zimmermann, TJ Rutherford, AR Fersht, AC Joerger, ... Journal of the American Chemical Society 134 (15), 6810-6818, 2012 | 248 | 2012 |
Crystal structure of a superstable mutant of human p53 core domain: insights into the mechanism of rescuing oncogenic mutations AC Joerger, MD Allen, AR Fersht Journal of Biological Chemistry 279 (2), 1291-1296, 2004 | 202 | 2004 |
Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations AC Joerger, HC Ang, DB Veprintsev, CM Blair, AR Fersht Journal of Biological Chemistry 280 (16), 16030-16037, 2005 | 198 | 2005 |
Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains HC Ang, AC Joerger, S Mayer, AR Fersht Journal of Biological Chemistry 281 (31), 21934-21941, 2006 | 173 | 2006 |
Structural evolution of p53, p63, and p73: implication for heterotetramer formation AC Joerger, S Rajagopalan, E Natan, DB Veprintsev, CV Robinson, ... Proceedings of the National Academy of Sciences 106 (42), 17705-17710, 2009 | 166 | 2009 |
Structural biology of the tumor suppressor p53 and cancer‐associated mutants AC Joerger, AR Fersht Advances in cancer research 97, 1-23, 2007 | 147 | 2007 |
Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant N Basse, JL Kaar, G Settanni, AC Joerger, TJ Rutherford, AR Fersht Chemistry & biology 17 (1), 46-56, 2010 | 142 | 2010 |
Design of a molecular support for cryo-EM structure determination TG Martin, TAM Bharat, AC Joerger, X Bai, F Praetorius, AR Fersht, ... Proceedings of the National Academy of Sciences 113 (47), E7456-E7463, 2016 | 119 | 2016 |
2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells MR Bauer, AC Joerger, AR Fersht Proceedings of the National Academy of Sciences 113 (36), E5271-E5280, 2016 | 115 | 2016 |
Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer E Natan, C Baloglu, K Pagel, SMV Freund, N Morgner, CV Robinson, ... Journal of molecular biology 409 (3), 358-368, 2011 | 111 | 2011 |
Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration E Arbely, E Natan, T Brandt, MD Allen, DB Veprintsev, CV Robinson, ... Proceedings of the National Academy of Sciences 108 (20), 8251-8256, 2011 | 104 | 2011 |